安達昂一郎｜教員紹介 | 薬物動態学研究室

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研究者名: 安達昂一郎（アダチコウイチロウ）
所属: 薬物動態学研究室
担当科目: 薬物動態実習
職位: 特任助教
学位: 博士（薬学）

学歴

2015年3月昭和薬科大学薬学部薬学科　卒業

2022年3月昭和薬科大学大学院薬学研究科薬学専攻博士課程修了　博士（薬学）

経歴

2015年4月　京都大学医学部付属病院　薬剤部

2016年11月独立行政法人国立病院機構京都医療センター　薬剤部

2020年4月　独立行政法人国立病院機構姫路医療センター　薬剤部

2022年4月　昭和薬科大学薬学部　薬物動態学研究室　特任助教

免許・資格

薬剤師

受賞歴

2015年　第25回医療薬学会年会優秀演題賞

所属学協会

日本医療薬学会

日本薬学会

日本中毒学会

日本化学療法学会

日本臨床救急医学会

研究分野

薬物動態学

急性薬物中毒

研究業績（論文）

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原著論文　Reported Liver Toxicity of Food Chemicals in Rats Extrapolated to Humans Using Virtual Human-to-Rat Hepatic Concentration Ratios Generated by Pharmacokinetic Modeling with Machine Learning-derived Parameters.　Koichiro Adachi, Manato Hosoi, Yukia Shimura, Makiko Shimizu, Hiroshi Yamazaki.　The Journal of Toxicological Sciences.,　50(5),　205-213　(2025)　
原著論文　Impact of Variability of In Silico and In Vitro Octanol/Water Partition Coefficients of Compounds on the Input Parameters and Results of Simplified Human Physiologically Based Pharmacokinetic Models after Virtual Oral Administrations.　Koichiro Adachi, Tsubasa Sasaki, Atsuo Arai, Makiko Shimizu, and Hiroshi Yamazaki.　The Journal of Toxicological Sciences.,　49 (10),　459-466　(2024)　
Breif Communication　Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman.　Koichiro Adachi, Maki Murata, Akiyoshi Inada, Takeyori Morimoto, Makiko Shimizu, Satoru Beppu, and Hiroshi Yamazaki.　ACUTE MEDICINE & SURGERY.,　11(1):e985.　　(2024)　関連リンク
原著論文　Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.　Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki.　Biological and Pharmaceutical Bulletin.,　47 (5),　1028-1032　(2024)　
原著論文　Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances.　Koichiro Adachi, Makiko Shimizu, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki.　The Journal of Toxicological Sciences.,　49,　127-137　(2024)　
原著論文　Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.　Koichiro Adachi , Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Makiko Shimizu, Hiroshi Yamazaki.　Biological & pharmaceutical bulletin.,　47(3),　635-640　(2024)　
Case Report　A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis – A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir.　Ryo Unita, Koichiro Adachi, Akiyoshi Inada, Makiko Shimizu, Satoru Beppu, hiroshi Yamazaki.　Journal of Infection and Chemotherapy.,　29(11),　1068-1070　(2023)　関連リンク
原著論文　Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients.　Koichiro Adachi, Masayoshi Utsumi, Tasuku Sato, Hina Nakano, Makiko Shimizu, Hiroshi Yamazaki.　Biological & pharmaceutical bulletin.,　46,　1316-1323　(2023)　
原著論文　Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats.　Koichiro Adachi, Hina Nakano, Tasuku Sato, Makiko Shimizu, Hiroshi Yamazaki .　Biological & pharmaceutical bulletin.,　46,　1133-1140　(2023)　
原著論文　Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database.　Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Hina Nakano, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito, and Hiroshi Yamazaki.　Biological & pharmaceutical bulletin.,　46,　856-863,　(2023)　
原著論文　High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4*16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database.　Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki.　Drug Metabolism and Pharmacokinetics.,　49,　100486,　(2023)　
Letter　Updated in silico prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for estimating internal concentrations in rats.　Koichiro Adachi, Makiko Shimizu, Hiroshi Yamazaki.　The Journal of Toxicological Sciences.,　47,　453-456,　(2022)　
原著論文　Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans.　Koichiro Adachi, Makiko Shimizu, and Hiroshi Yamazaki.　Biological & pharmaceutical bulletin.,　45,　1812-1817,　(2022)　
原著論文　救急搬送事例となった企図的過量服用医薬品等の適正投与時の生理学的薬物動態モデルを用いた血中薬物動態再現の基盤研究　安達昂一郎、別府賢、清水万紀子、福田利明、山崎浩史　中毒研究　35巻第3号　179-185　(2022)　
原著論文　Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital.　Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu and Hiroshi Yamazaki.　Journal of Pharmaceutical Health Care and Sciences.,　7,　32　(2021)　
原著論文　Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital.　Koichiro Adachi, Satoru Beppu, Mariko Terashima, Toshiaki Fukuda, Jun Tomizawa, Makiko Shimizu and Hiroshi Yamazaki.　Journal of Pharmaceutical Health Care and Sciences.,　7,　36　(2021)　
原著論文　Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital.　Koichiro Adachi, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki.　Journal of Pharmaceutical Health Care and Sciences.,　7,　6　(2021)　
原著論文　Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital.　Koichiro Adachi, Yuki Sugitani, Ryo Unita, Kosuke Yoshida, Satoru Beppu, Mariko Terashima, Masaya Fujii, Makiko Shimizu, and Hiroshi Yamazaki.　Journal of Pharmaceutical Health Care and Sciences.,　7,　33　(2021)　
原著論文　Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital.　Koichiro Adachi, Jumpei Tuchiya, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki.　Journal of Pharmaceutical Health Care and Sciences.,　6,　20　(2020)　
原著論文　病院と薬局の合意に基づく院外処方せんにおける疑義照会簡素化プロトコルとその効果　櫻井香織，尾崎淳子，矢野育子，安達昂一郎，木村嘉彦，松村勝之，西脇布貴吉田優子，池見泰明，萱野勇一郎，米澤　淳，深津祥央，松原和夫＊　医療薬学　42巻5号　336-342　(2016)　
原著論文　Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.　Koichiro Adachi, Hiroshi Suemizu, Norie Murayama, Makiko Shimizu and Hiroshi Yamazaki .　Environmental Toxicology and Pharmacology.,　39,　1067-73　(2015)

すべて表示する

競争的資金等

「急性薬物中毒症例への消化管除染適用時間可視化のための生理学的薬物動態モデルの適応」　科研費（若手) 2023年4月 - 2026年3月（23K14393）

安達 昂一郎特任助教 / 博士（薬学）last update : 2025.02.01