種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances." "Koichiro Adachi, Makiko Shimizu, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki." "The Journal of Toxicological Sciences.," 49, 127-137 (2024) https://doi.org/10.2131/jts.49.127 原著論文 "Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database." "Koichiro Adachi , Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Makiko Shimizu, Hiroshi Yamazaki." "Biological & pharmaceutical bulletin.," 47(3), 635-640 (2024) 10.1248/bpb.b24-00012. "Case Report" "A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis – A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir." "Ryo Unita, Koichiro Adachi, Akiyoshi Inada, Makiko Shimizu, Satoru Beppu, hiroshi Yamazaki." "Journal of Infection and Chemotherapy.," 29(11), 1068-1070 (2023) https://doi.org/10.1016/j.jiac.2023.07.001 https://doi.org/10.1016/j.jiac.2023.07.001 原著論文 "Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients." "Koichiro Adachi, Masayoshi Utsumi, Tasuku Sato, Hina Nakano, Makiko Shimizu, Hiroshi Yamazaki." "Biological & pharmaceutical bulletin.," 46, 1316-1323 (2023) 10.1248/bpb.b23-00371 原著論文 "Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats." "Koichiro Adachi, Hina Nakano, Tasuku Sato, Makiko Shimizu, Hiroshi Yamazaki ." "Biological & pharmaceutical bulletin.," 46, 1133-1140 (2023) 10.1248/bpb.b23-00358 原著論文 "Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database." "Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Hina Nakano, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito, and Hiroshi Yamazaki." "Biological & pharmaceutical bulletin.," 46, 856-863, (2023) https://doi.org/10.1248/bpb.b23-00189 原著論文 "High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4*16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database." "Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki." "Drug Metabolism and Pharmacokinetics.," 49, 100486, (2023) 10.1016/j.dmpk.2022.100486 Letter "Updated in silico prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for estimating internal concentrations in rats." "Koichiro Adachi, Makiko Shimizu, Hiroshi Yamazaki." "The Journal of Toxicological Sciences.," 47, 453-456, (2022) https://doi.org/10.2131/jts.47.453 原著論文 "Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans." "Koichiro Adachi, Makiko Shimizu, and Hiroshi Yamazaki." "Biological & pharmaceutical bulletin.," 45, 1812-1817, (2022) 10.1248/bpb.b22-00502 原著論文 "救急搬送事例となった企図的過量服用医薬品等の適正投与 時の生理学的薬物動態モデルを用いた血中薬物動態再現の基盤研究" "安達昂一郎、別府 賢、清水万紀子、福田利明、山崎浩史" 中毒研究 35巻第3号 179-185 (2022) 原著論文 "Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital." "Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu and Hiroshi Yamazaki." "Journal of Pharmaceutical Health Care and Sciences.," 7, 32 (2021) 10.1186/s40780-021-00215-w 原著論文 "Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital." "Koichiro Adachi, Satoru Beppu, Mariko Terashima, Toshiaki Fukuda, Jun Tomizawa, Makiko Shimizu and Hiroshi Yamazaki." "Journal of Pharmaceutical Health Care and Sciences.," 7, 36 (2021) 10.1186/s40780-021-00220-z 原著論文 "Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital." "Koichiro Adachi, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki." "Journal of Pharmaceutical Health Care and Sciences.," 7, 6 (2021) 10.1186/s40780-021-00189-9 原著論文 "Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital." "Koichiro Adachi, Yuki Sugitani, Ryo Unita, Kosuke Yoshida, Satoru Beppu, Mariko Terashima, Masaya Fujii, Makiko Shimizu, and Hiroshi Yamazaki." "Journal of Pharmaceutical Health Care and Sciences.," 7, 33 (2021) 10.1186/s40780-021-00216-9 原著論文 "Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital." "Koichiro Adachi, Jumpei Tuchiya, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki." "Journal of Pharmaceutical Health Care and Sciences.," 6, 20 (2020) 10.1186/s40780-020-00176-6 原著論文 病院と薬局の合意に基づく院外処方せんにおける疑義照会簡素化プロトコルとその効果 "櫻井香織,尾崎淳子,矢野育子,安達昂一郎,木村嘉彦,松村勝之,西脇布貴 吉田優子,池見泰明,萱野勇一郎,米澤 淳,深津祥央,松原和夫*" 医療薬学 42巻5号 336-342 (2016) 10.5649/jjphcs.42.336 原著論文 "Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling." "Koichiro Adachi, Hiroshi Suemizu, Norie Murayama, Makiko Shimizu and Hiroshi Yamazaki ." "Environmental Toxicology and Pharmacology.," 39, 1067-73 (2015) 10.1016/j.etap.2015.02.011