論文リスト(Publications 2008〜)last update : 2024.11.19

 

  1. Gold-Catalyzed Propargylic Substitution Followed by Cycloisomerization in Ionic Liquid: Environmentally Friendly Synthesis of Polysubstituted Furans from Propargylic Alcohols and 1,3-Dicarbonyl Compounds.
    Chiaki, H.; Hashimoto, Y.; Morita, N.
    Molecules 2024, 29, 5441.
     

     

  2. Hetero Cope-Type Hydroamination of Hetero-Allenes with Oximes Having Olefin Moieties Leading to Nitrones, Causing Intramolecular Cycloaddition.
    Ide, Y.; Matsuda, N.; Osada, M.; Yamamoto, A.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.
    J. Org. Chem. 2024, 89, 12973–12981.
     

     

  3. Discovery of a Formal Dyotropic Rearrangement during Acid-Mediated Dioxabicyclo[4.2.1]nonanone Formation.
    Hashimoto, Y.; Kong W.-Y.; Tantillo, D. J. ( equal contribution)
    Org. Lett. 2024, 26, 5441–5446.
     

     

  4. An Efficient Stereoselective Synthesis of cis-2,6-Disubstituted Tetrahydropyrans via Gold-Catalyzed Meyer–Schuster Rearrangement/Hydration/oxa-Michael Addition Sequence.
    Morita, N.; Yamashita, D.; Hashimoto, Y.; Tamura, O.
    Catalysts 2024, 14, 228.
     

     

  5. (E)-5-[Bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole.
    Morita, N.; Kurami, S.; Ishii, N.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.
    Molbank 2024, 2024, M1769.
     

     

  6. Gold(III)-Catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N-Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds.
    Morita, N.; Uchida, S.; Chiaki, H.; Ishii, N.; Tanikawa, K.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.
    Molecules 2024, 29, 378.
     

     

  7. Intermolecular 1,3-Dipolar Cycloaddition Reaction of N-Carbamoyl Nitrones Generated by N-Selective Carbamoylation of Oximes with Isocyanates.
    Yamamoto, A.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.
    Chem. Eur. J., 2024, 30, e202303790.
    本論文はHot Paperに選出されました。
     

     

2023

 

  1. Direct Generation of N-Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties.
    Sagara, H.; Suzuki, Y.; Morita, N.; Ban, S.; Tanaka, K. III; Yamamoto, A.; Hashimoto, Y.; Tamura, O.
    Adv. Synth. Catal. 2023, 365, 3927–3934.
     

     

  2. Electrophilic C3−H Alkenylation of 2,6-Dialkoxypyridine Derivatives via Pd(II)/Tl(III) Reaction System.
    Yamada, T.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.
    Adv. Synth. Catal. 2023, 365, 3138–3148.
    本論文はWiley社の"Hot Topic: C–H Activation"で紹介されました。
     

     

  3. Synthesis of N-Aryl Isoxazolidines by Photo-Promoted N-Selective Arylation of Oximes and Cyclization Using Hypervalent Iodine Reagents and Copper Catalyst.
    Tanaka, K. III; Yoshida, M.; Yamamoto, A.; Hashimoto, Y.; Morita, N.; Tamura, O.
    Adv. Synth. Catal. 2023, 365, 1419–1424.
     

     

  4. (Z)-5-Benzylidene-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole.
    Morita, N.; Chiaki, H.; Aonuma, S.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.
    Molbank 2023, 2023, M1600.
     

     

  5. Sustainable Chemical Synthesis of 2,3-Dihydrobenzofurans/1,2,3-Trisubstituted Indanes in Water Using a Permethylated β-Cyclodextrin-tagged NHC-Gold Catalyst.
    Morita, N.; Chiaki, H.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.; Krause, N.
    Synlett 2023, 34, 1425–1432.
     

     

  6. Gold-Catalyzed Formal (3+2) Cycloaddition in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Poly-substituted Indanes from Benzyl Alcohols with 1-Phenylpropenes.
    Morita, N.; Chiaki, H.; Ikeda, K.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.
    Synlett 2023, 34, 1068–1074.
     

     

2022

 

  1. Directing-Group-Free Palladium-Catalyzed C–H Arylation of Aldoxime Using Oxime’s Umpolung Properties.
    Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.
    Org. Lett. 2022, 24, 8954–8958.
     

     

  2. Mechanism and the Origins of Periselectivity in Cycloaddition Reactions of Benzyne with Dienes.
    Hashimoto, Y.; Tantillo, D. J.
    J. Org. Chem. 2022, 87, 12954–12962.
     

     

  3. Cationic palladium(II)-catalyzed synthesis of substituted pyridines from α,β-unsaturated oxime ethers.
    Yamada, T.; Hashimoto, Y.; Tanaka, K. III; Morita, N.; Tamura, O.
    RSC Adv. 2022, 12, 21548–21557.
     

     

2021

 

  1. Enantioselective total synthesis of (+)-rubrobramide, (+)-talaramide A, and (−)-berkeleyamide D by a skeletal diversification strategy.
    Tanaka, K. III; Kobayashi, K.; Kogen, H.
    Chem. Commun. 2021, 57, 9780–9783.
     
  2. Electrophilic Epoxidation of α,β-Unsaturated Oximes with Dioxiranes and Ring Opening of the Epoxides.
    Furugoori, M.; Yoshida, K.; Hashimoto, Y.; Morita, N.; Tanaka, K. III; Tamura, O.
    Chem. Pharm. Bull. 2021, 69, 1010–1016.
     

     

  3. Gold-Catalyzed Formal [3+2] Cycloaddition of p-Quinones and 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Benzofuran Neolignans.
    Morita, N.; Ikeda, K.; Chiaki, H.; Araki, R.; Tanaka, K. III; Hashimoto Y.; Tamura, O.
    Heterocycles 2021, 103, 714–722.
     

     

  4. Palladium(II)-Catalyzed Substituted Pyridine Synthesis from α,β-Unsaturated Oxime Ethers via a C–H Alkenylation/Aza-6π-Electrocyclization Approach.
    Yamada, T.; Hashimoto, Y.; Tanaka, K. III; Morita, N.; Tamura, O.
    Org. Lett. 2021, 23, 1659–1663.
     

     

  5. Highly Oxidized γ-Lactam-Containing Natural Products: Total Synthesis and Biological Evaluation.
    Tanaka, K. III; Kogen, H.; Kobayashi, K.
    Heterocycles 2021, 102, 1235–1285.
     

2020

 

  1. Thioether Ligand-Enabled Cationic Palladium(II)-Catalyzed Electrophilic C-H Arylation of α,β-Unsaturated Oxime Ethers.
    Yamada, T.; Hashimoto, Y.; Tanaka, K. III; Morita, N.; Tamura, O.
    J. Org. Chem. 2020, 85, 12315–12328.
     

     

  2. Synthesis and Formation Mechanism of a Compound with an Unprecedented Skeleton: Dodecahydro-4,10:5,9-diepoxydipyrrolo[3,4-b:3',4'-f][1,5]diazocine.
    Shinoda, M.; Morita, N.; Tanaka, K. III; Hashimoto, Y.; Ban, S.; Tamura, O.
    Chem. Pharm. Bull. 2020, 68, 1238–1243.
     

     

  3. Intramolecular Activation of Imidate with Cationic Gold(I) Catalyst: a New Benzylation Reaction of Alcohols
    Ban, S.; Endo, T.; Matsui, R.; Morita, N.; Hashimoto, Y.; Tanaka, K. III; Tamura, O.
    Tetrahedron Lett. 2020, 61, 152233–152235.
     

     

  4. O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups.
    Suzuki, T.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.
    Synlett 2020, 31, 899–902.
     

     

2019

 

  1. Studies toward Identifying the Pharmacophore of L-755,807 for Amyloid-β Aggregation Inhibitory Activity.
    Kobayashi, K.; Tanaka, K. III; Honma, Y.; Suzuki, M.; Kogen, H.
    Heterocycles 2019, 98, 1769–1776.
     
  2. Chelation-Based Homologation by Reaction of Organometallic Reagents with O-Alkyl S-Pyridin-2-yl Thiocarbonates: Synthesis of Esters from Grignard Reagents.
    Usami, S.; Suzuki, T.; Mano, K.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.
    Synlett 2019, 30, 1561–1564.
    本論文は有機合成化学協会誌2019年11月号のNew Synthetic Methodsに取り上げられました。
     

     

  3. Total Synthesis and Amyloid β Aggregation Inhibitory Activity of (−)-L-755,807.
    Tanaka, K. III; Kobayashi, K.; Kogen, H.
    J. Synth. Org. Chem. Jpn. 2019, 77, 673–683.
     
  4. Inverse-Electron-Demand oxa-Diels–Alder Reactions of α-Keto-β,γ-unsaturated Esters and α,β-Unsaturated Hydrazones.
    Hashimoto, Y.; Ikeda, T.; Ida, A.; Morita, N.; Tamura, O.
    Org. Lett. 2019, 21, 4245–4249.
     

     

2018

 

  1. Inverse-electron-demand Diels–Alder reactions of α,β-unsaturated hydrazones with 3-methoxycarbonyl α-pyrones.
    Hashimoto, Y.; Abe, R.; Morita, N.; Tamura, O.
    Org. Biomol. Chem. 2018, 16, 8913–8916.
     

     

  2. Efficient One-Pot Synthesis of Substituted Oxazoles from 3-Trimethylsilylpropargylic Alcohols and Amides by Gold-Catalyzed Substitution Followed by Cycloisomerization.
    Morita, N.; Sano, A.; Sone, A.; Aonuma, S.; Matsunaga, A.; Hashimoto, Y.; Tamura, O.
    Heterocycles 2018, 97, 719–728.
     

     

2017

 

  1. Total Synthesis of Neodysiherbaine A via 1,3-Dipolar Cycloaddition of a Chiral Nitrone Template.
    Hirai, T.; Shibata, K.; Niwano, Y.; Shiozaki, M.; Hashimoto, Y.; Morita, N.; Ban, S.; Tamura, O.
    Org. Lett. 2017, 19, 6320–6323.
     

     

  2. First Total Syntheses of Tetracenomycins C and X.
    Sato, S.; Sakata, K.; Hashimoto, Y.; Takikawa, H.; Suzuki, K.
    Angew. Chem. Int. Ed. 2017, 56, 12608–12613.
     
  3. Thiyl radical-mediated cyclization of ω-alkynyl O-tert-butyldiphenylsilyloximes.
    Shibata, N.; Tsuchiya, T.; Hashimoto, Y.; Morita, N.; Ban, S.; Tamura, O.
    Org. Biomol. Chem. 2017, 15, 3025–3034.
     

     

  4. Total synthesis of (-)-phaeosphaeride B by a biomimetic conversion from (-)-phaeosphaeride A.
    Kobayashi, K.; Kunimura, R.; Tanaka, K. III; Tamura, O.; Kogen, H.
    Tetrahedron 2017, 73, 2382–2388.
     
  5. Utilization of electron-donating α,β-unsaturated oximes: regioselective inverse 1,3-dipolar cycloaddition of nitrones.
    Hashimoto, Y.; Ishiwata, H.; Tachikawa, S.; Ban, S.; Morita, N.; Tamura, O.
    Chem. Commun. 2017, 53, 2685–2688.
     

     

  6. Gold(III)-Catalyzed Synthesis of 2,3,4-Trisubstituted Dihydropyrans from Propargylic Alcohols with 1,3-Dicarbonyl Compounds.
    Morita, N.; Oguro, K.; Takahashi, S.; Kawahara, M.; Ban, S.; Hashimoto, Y.; Tamura, O.
    Heterocycles 2017, 95, 172–180.
     

     

2016

 

  1. Gold-catalyzed dehydrative Friedel–Crafts reaction and Nazarov cyclization sequence: an efficient synthesis of 1,3-diarylindenes from propargylic alcohols.
    Morita, N.; Miyamoto, M.; Yoda, A.; Yamamoto, M.; Ban, S.; Hashimoto, Y.; Tamura, O.
    Tetrahedron Lett. 2016, 57, 4460–4463.
     

     

  2. Gold-Catalyzed Synthesis of 2-Substituted Azepanes: Strategic Use of Soft Gold(I) and Hard Gold(III) Catalysts.
    Morita, N.; Saito, Y.; Muraji, A.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.
    Synlett, 2016, 27, 1936–1940.
     

     

  3. Pleospdione, A Tricyclic Natural Product with Dense Oxygenation at the A Ring: Total Synthesis and Incongruity of the Originally Assigned Structure and Its C3-Epimer.
    Takikawa, H.; Ishikawa, Y.; Yoshinaga, Y.; Hashimoto, Y.; Kusumi, T.; Suzuki, K.
    Bull. Chem. Soc. Jpn. 2016, 89, 941–954.
     
  4. Gold-Catalyzed Dimeric Cyclization of Isoeugenol and Related 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of 1,2,3-Trisubstituted 2,3-Dihydro-1H-indenes.
    Morita, N.; Mashiko, R.; Hakuta, D.; Eguchi, D.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.
    Synthesis 2016, 48, 1927–1933.
     

     

  5. Acid-induced molecular-structural transformation of N-methyl aromatic oligoamides bearing pyridine-2-carboxamide.
    Yamasaki, R.; Fujikake, S.; Ito, A.; Migita, K.; Morita, N.; Tamura, O.; Okamoto, I.
    Tetrahedron Lett. 2016, 57, 56–59.
     

2015

 

  1. Gold(I)/(III)-Catalyzed Synthesis of 2-Substituted Piperidines; Valency-Controlled Cyclization Modes.
    Morita, N.; Tsunokake, T.;Narikiyo, Y.; Harada, M.; Tachibana, T.; Saito, Y.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.
    Tetrahedron Lett. 2015, 56, 6269–6272.
     

     

  2. Gold(I)/(III)-Catalyzed Synthesis of Cyclic Ethers; Valency-Controlled Cyclization Modes.
    Morita, N.; Yasuda, A.; Shibata, M.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.
    Org. Lett. 2015, 17, 2668–2671.
     

     

  3. BF3-Mediated cis-Selective Cycloaddition of O-Silyloxime with Alkenes.
    Morita, N.; Kono, R.; Fukui, K.; Miyazawa, A.; Masu, H.; Azumaya, I.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.
    J. Org. Chem. 2015, 80, 4797–4802.
     

     

  4. Total Synthesis of Maremycins A and D1 Using Chiral and Cyclic Nitrone with (E)-3-Ethylidene-1-methylindolin-2-one.
    Ueda, T.; Inada, M.; Morita, N.; Tamura, O.
    Heterocycles 2015, 90, 1179–1195.
     

     

  5. Establishment of Relative and Absolute Configurations of Phaeosphaeride A: Total Synthesis of ent-Phaeosphaeride A.
    Kobayashi, K.; Kobayashi, Y.; Nakamura, M.; Tamura, O.; Kogen, H.
    J. Org. Chem. 2015, 80, 1243–1248.
     

2014–2008

 

  1. Isoxazole Platform for Polyketide Assembly: Cycloaddition of Stable Benzonitrile Oxides to Stable ortho-Quinone Monoacetals and Dehydrogenation.
    Takikawa, H.; Hashimoto, Y.; Suzuki, K.
    Chem. Lett. 2014, 43, 1607-1609.
     
  2. Redox-Responsive Conformational Alteration of Aromatic Amides Bearing N-Quinonyl System.
    Okamoto, I.; Takahashi, Y.; Sawamura, M.; Matsumura, M.; Masu, H.; Katagiri, K.; Azumaya, I.; Nishino, M.; Kohama, Y.; Morita, N.; Tamura, O.; Kagechika, H.; Tanatani, A.
    Tetrahedron 2012, 68, 5346-5355.
     
  3. Acid-Induced Conformational Alteration of cis-Preferential Aromatic Amides Bearing N-Methyl-N-(2-Pyridyl) Moiety.
    Okamoto, I.; Terashima, M.; Masu, H.; Nabeta, M.; Ono, K.; Morita, N.; Katagiri, K.; Azumaya, I.; Tamura, O.
    Tetrahedron 2011, 67, 8536-8543.
     
  4. Stereoselective Vinylogous Mannich Reaction of 2-Trimethylsilyloxyfuran with N-Gulosyl Nitrones.
    Tamura, O.; Takeda, K.; Mita, N.; Sakamoto, M.; Okamoto, I.; Morita, N.; Ishibashi, H.
    Org. Biomol. Chem. 2011, 9, 7411-7419.
     
  5. Convenient Synthesis of Aminopyridinecarboxylic Acids.
    Okamoto, I.; Terashima, M.; Yoshioka, R.; Muramatsu, T.; Kojima, S.; Inoue, H.; Takahashi, M.; Morita, N.; Tamura, O.
    Heterocycles 2011, 83, 2343-2352.
     
  6. Synthesis of the Proposed Structure of Phaeosphaeride A.
    Kobayashi, K.; Okamoto, I.; Morita, N.; Kiyotani, T.; Tamura, O.
    Org. Biomol. Chem. 2011, 9, 5825-5832.
     
  7. Synthesis and Biological Evaluation of Tubulysin D Analogues Related to Stereoisomers of Tubuvaline.
    Shibue, T.; Okamoto, I.; Morita, N.; Morita, H.; Hirasawa, Y.; Hosoya, T.; Tamura, O.
    Bioorg. Med. Chem. Lett. 2011, 21, 431-434.
     
  8. Total Syntheses of Tubulysins.
    Shibue, T.; Hirai, T.; Okamoto, I.; Morita, N.; Masu, H.; Azumaya, I.; Tamura, O.
    Chem. Eur. J. 2010, 16, 11678-11688.
     
  9. Products of Thymine Oxygenation by a Non-heme Oxygenation Model, FeII(MeCN)62+-Ac2O-H2O2, and the Transition State Model between Oxoiron and Thymine.
    Kobayashi, S.; Takagi, A.; Chikuma, T.; Tamura, O.; Kotani, E.; Katase, T.
    Chem. Pharm. Bull. 2010, 58, 775-781.
     
  10. Synthesis and Evaluation of Opioid Receptor-binding Affinity of Elaeocarpenine and its Analogs.
    Kurasaki, H.; Okamoto, I.; Morita, N.; Tamura, O.
    Bioorg. Med. Chem. Lett. 2010, 20, 1601-1603.
     
  11. Oxidative Dimerization of 4-Methoxynaphthylamines in the Presence of Semiconductors.
    Takeya, T.; Takahashi, Y.; Okamoto, I.; Tamura, O.
    Heterocycles 2010, 80, 1479-1488.
     
  12. A Flexible Approach to Grandisine Alkaloids: Total Synthesis of Grandisine B, D and F.
    Kurasaki, H.; Okamoto, I.; Morita, N.; Tamura, O.
    Chem. Eur. J. 2009, 15, 12754-12763.
     
  13. Stereoselective Synthesis of Tubuvaline Methyl Ester and Tubuphenylalanine, Components of Tubulysins, Tubulin Polymerization Inhibitors.
    Shibue, T.; Hirai, T.; Okamoto, I.; Morita, N.; Masu, H.; Azumaya, I.; Tamura, O.
    Tetrahedron Lett. 2009, 50, 3845-3848.
     
  14. Intermolecular Carbon Radical Addition to Cyclic Nitrone.
    Ueda, M.; Miyabe, H.; Nonoguchi, N.; Miyata, O.; Tamura, O.; Naito, T.
    Heterocycles 2009, 79, 739-751.
     
  15. Total Synthesis of Grandisine D.
    Kurasaki, H.; Okamoto, I.; Morita, N.; Tamura, O.
    Org. Lett. 2009, 11, 1179-1181.
     
  16. Intermolecular Cycloaddition of N-Boranonitrone with Alkenes.
    Morita, N.; Fukui, K.; Irikuchi, J.; Sato, H.; Takano, Y.; Okamoto, I.; Ishibashi, H.; Tamura, O.
    J. Org. Chem. 2008, 73, 7164-7174.
     
  17. Golden Opportunities in catalysis.
    Krause, N.; Beitings, V.; Deutsch, C.; Erdsack, J.; Fan, H. -T.; Gockel, B.; Hoffmann-Roder, A.; Morita, N.; Voltz, F.
    Pure Appl. Chem. 2008, 80, 1063-1069.
     
  18. Synthesis of Maremycins A and D1 via Cycloaddition of a Nitrone with (E)-3-Ethylidene-1-methylindolin-2-one.
    Ueda, T.; Inada, M.; Okamoto, I.; Morita, N.; Tamura, O.
    Org. Lett. 2008, 10, 2043-2046.
     
  19. Synthesis of Nitrogen Containing Heterocycles Using Exo and Endo Selective Radical Cyclizations onto Enamides.
    Taniguchi, T.; Yonei, D.; Uchihara, Y.; Sasaki, M.; Tamura, O.; Ishibashi, H.
    Tetrahedron 2008, 64, 2634-2641.
     

 

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