教員

金本 大成教授 / 博士(歯学)last update : 2022.12.14

English

プロフィール

研究者名
金本 大成(カナモト タイセイ)
所属
微生物学研究室
担当科目
微生物学 (2年後期)
微生物免疫実習 (3年前期)
免疫学 (3年前期)
感染制御学 (3年後期)
新興感染症 (6年前期)
職位
教授
学位
博士(歯学)

学歴

1988年3月 九州大学歯学部 卒業

1988年4月 九州大学大学院歯学研究科 入学

1992年3月 同 上 単位取得の上満期退学

1994年6月 博士(歯学)

経歴

1992年4月 九州大学歯学部附属病院 医員(小児歯科)

1993年10月 鹿児島大学歯学部 予防歯科学教室 助手

1999年4月 同 上 口腔細菌学教室 助手

2003年12月 米国バージニアコモンウェルス大学フィリップス研究所 博士研究員

2006年7月 聖マリアンナ医科大学 微生物学教室 助手

2007年10月 同 上 講師

2017年4月 昭和薬科大学 微生物学研究室 教授

免許・資格

  • 歯科医師免許

所属学協会

日本感染症学会

日本化学療法学会

日本細菌学会

American Society for Microbiology

  • デンタルスタッフの口腔衛生学・歯科衛生統計 泉福英信 編 4章 VI全身疾患と口腔への関連性 (2) 心疾患 120-123 医歯薬出版 2018 978-4-263-42246-5
  • 微生物学 -基礎から臨床へのアプローチ- 神谷茂、河野茂 監訳 第13章 ウイルスの病原性  メディカル・サイエンス・インターナショナル 2012 978-4-89592-704-8
  • ウイルス感染症との戦い -現状と21世紀への展望- 茂田士郎、満屋裕明 編 III 新しい抗ウイルス療法の戦略 4. ポリペプチド 473-481 医薬ジャーナル社 2000 4-7532-1830-9
  • 原著論文 Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5 Kajikawa M, Hata M, Ishimura M, Imaizumi N, Kimura M, Miyano K, Ose T, Asai D, Ishido S, Kanamoto T. Biochem J 479 2261-2278 2022 
  • 原著論文 Kaposi's sarcoma-associated herpesvirus ubiquitin ligases downregulate cell surface expression of l-selectin. Kajikawa M, Imaizumi N, Machii S, Nakamura T, Harigane N, Kimura M, Miyano K, Ishido S, Kanamoto T J Gen Virol 102  2021 
  • 原著論文 Lignosulfonate Rapidly Inactivates Human Immunodeficiency and Herpes Simplex Viruses. Fukuchi K, Koshikawa T, Asai D, Inomata M, Sakagami H, Takemura H, Kanamoto T, Aimi H, Kikkawa Y. Medicines (Basel) 8 56 2021 
  • 原著論文 Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue. Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S. Medicines (Basel) 8 33 2021 
  • 原著論文 Synthesis, antibacterial activities, and sustained perfume release properties of optically active5-hydroxy- and 5-acetoxyalkanethioamide analogues. Shimotori Y, Hoshi M L, Ogawa N, Miyakoshi T, Kanamoto T Heterocycl Commun. 26 84-98 2020 
  • 原著論文 Elucidation of anti-HIV mechanism of sulfated cellobiose-polylysine dendrimers. Weiyue S, Ying L, Kanamoto T, Asai D, Takemura H, Nakashima H, Miyazaki K, Yoshida T. Carbohydr Res. 495 108084 2020 
  • 原著論文 Interaction between sulfated 3-O-octadecyl-α-(1→6)-d-glucan and liposomes analyzed by surface plasmon resonance. Budragchaa D, Shiming B, Kanamoto T, Nakashima H, Miyazaki K, Yoshida T. Carbohydr Polym. 239 116022 2020 
  • 原著論文 Analysis of interaction between sulfated polysaccharides and HIV oligopeptides by surface plasmon resonance.  Battulga T, Tumurbaatar O, Ganzorig O, Ishimura T, Kanamoto T, Nakashima H, Miyazaki K, Yoshida T.  Int J Biol Macromol 125 909-914 2019 
  • 原著論文 Antimicrobial Susceptibilities of Oral Isolates of Abiotrophia and Granulicatella According to the Consensus Guidelines for Fastidious Bacteria. Kanamoto T, Terakubo S, Nakashima H. Medicines (Basel) 5 129 2018 
  • 原著論文 Synthesis of dibenzothiazepine analogues by one-pot S-arylation and intramolecular cyclization of diaryl sulfides and evaluation of antibacterial properties. Shimotori Y, Hoshi M, Murata M, Ogawa N, Miyakoshi T, Kanamoto T Heterocycl Commun 24 219-230 2018 
  • 原著論文 Synthesis, odour characteristics and antibacterial activities of the steroisomeric forms of whisky lactone and its thiono analogues Shimotori Y, Hoshi M, Okabe H, Miyakoshi T, Kanamoto T, Nakashima H. Flavour Fragr J. 32 29-35 2017     
  • 原著論文 Quantitative Structure-Cytotoxicity Relationship of Chalcones. Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Anticancer Res. 37 1091-1098 2017     
  • 原著論文 Isolation and antiviral activity of water-soluble Cynomorium songaricum Rupr. polysaccharides. Tuvaanjav S, Shuqin H, Komata M, Ma C, Kanamoto T, Nakashima H, Yoshida T. J Asian Nat Prod Res. 18 159-171 2016     
  • 原著論文 Chemically sulfated natural galactomannans with specific antiviral and anticoagulant activities. Muschin T, Budragchaa D, Kanamoto T, Nakashima H, Ichiyama K, Yamamoto N, Shuqin H, Yoshida T. Int J Biol Macromol. 89 415-420 2016     
  • 原著論文 Synergism of Alkaline Extract of the Leaves of Sasa senanensis Rehder and Antiviral Agents. Sakagami H, Fukuchi K, Kanamoto T, Terakubo S, Nakashima H, Natori T, Suguro-Kitajima M, Oizumi H, Yasui T, Oizumi T. In Vivo. 30 421-426 2016     
  • 原著論文 Antiviral and Antitumor Activity of Licorice Root Extracts. Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H. In Vivo. 30 777-785 2016     
  • 総説 イヌトウキの生物活性と今後の展望 坂上 宏、佐藤和恵、金本大成、寺久保繁美、中島秀喜、牧 純、白瀧義明、三間 修、斎田圭子 New Food Industry 57 35-39 2015     
  • 原著論文 Development of a cashew nut shell liquid (CNSL)-based polymer for antibacterial activity. Kanehashi S, Masuda R, Yokoyama K, Kanamoto T, Nakashima H, Miyakoshi T.   J Appl Polym Sci 132 42725-42733 2015     
  • 原著論文 Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers Bai S, Budragchaa D, Han S, Kanamoto T, Nakashima H,Yoshida T. Int J Polym Sci. 2015  2015     
  • 原著論文 Synthetic galactomannans with potent anti-HIV activity. Budragchaa D, Bai S, Kanamoto T, Nakashima H, Han S, Yoshida T. Carbohydr Polym. 130 233-242 2015     
  • 原著論文 Quantitative Structure-Cytotoxicity Relationship of Oleoylamides. Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y. Anticancer Res. 35 5341-5351 2015     
  • 原著論文 Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y. Anticancer Res. 35 5299-52307 2015     
  • 原著論文 Quantitative structure-cytotoxicity relationship of phenylpropanoid amides. Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H. Anticancer Res. 34 3543-3548. 2014     
  • 原著論文 Efficient utilization of licorice root by alkaline extraction. Ohno H, Miyoshi S, Araho D, Kanamoto T, Terakubo S, Nakashima H, Tsuda T, Sunaga K, Amano S, Ohkoshi E, Sakagami H, Satoh K, Yamamoto M. In Vivo. 28 785-794 2014     
  • 原著論文 Quantitative structure-cytotoxicity relationship of piperic acid amides. Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Anticancer Res. 34 4877-4884 2014     
  • 原著論文 Quantitative structure-cytotoxicity relationship of 3-styrylchromones. Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H. Anticancer Res. 34 5405-5411 2014     
  • 原著論文 Biological interaction between Sasa senanensis Rehder leaf extract and toothpaste ingredients. Sakagami H, Amano S, Yasui T, Satoh K, Shioda S, Kanamoto T, Terakubo S, Nakashima H, Watanabe K, Sugiura T, Kitajima M, Oizumi H, Oizumi T. In Vivo. 27 275-284 2013     
  • 原著論文 Sulfation and biological activities of konjac glucomannan. Bo S, Muschin T, Kanamoto T, Nakashima H, Yoshida T. Carbohydr Polym. 94 899-903 2013     
  • 原著論文 Efficient Utilization of Plant Resources by Alkaline Extraction Sakagami H, Ohkoshi E, Amano S, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Sunaga K, Otsuki T, Ikeda H, Fukuda T. Altern Integ Med 2  2013     
  • 原著論文 Comparative study of biological activity of three commercial products of Sasa senanensis Rehder leaf extract. Sakagami H, Iwamoto S, Matsuta T, Satoh K, Shimada C, Kanamoto T, Terakubo S, Nakashima H, Morita Y, Ohkubo A, Tsuda T, Sunaga K, Kitajima M, Oizumi H, Oizumi T. In Vivo. 26 259-264 2012     
  • 原著論文 Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract. Sakagami H, Matsuta T, Satoh K, Ohtsuki S, Shimada C, Kanamoto T, Terakubo S, Nakashima H, Morita Y, Ohkubo A, Tsuda T, Sunaga K, Maki J, Sugiura T, Kitajima M, Oizumi H, Oizumi T. In Vivo. 26 411-418 2012     
  • 原著論文 Synthesis of a new amphiphilic glycodendrimer with antiviral functionality. Han S, Kanamoto T, Nakashima H, Yoshida T. Carbohydr Polym. 90 1061-1068 2012     
  • 原著論文 Anti-UV/HIV activity of Kampo medicines and constituent plant extracts. Kato T, Horie N, Matsuta T, Naoki U, Shimoyama T, Kaneko T, Kanamoto T, Terakubo S, Nakashima H, Kusama K, Sakagami H. In Vivo. 26 1007-1013 2012     
  • 原著論文 Synthesis and specific influenza A virus-adsorptive functionality of alkyl curdlan sulfate-coated membrane filter Muschin T, Han S, Kanamoto T, Nakashima H, Yoshida T. J Polymer Sci A Polymer Chem. 49 3241-3247 2011     
  • 原著論文 Anti-HIV and immunomodulation activities of cacao mass lignin-carbohydrate complex. Sakagami H, Kawano M, Thet MM, Hashimoto K, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Haishima Y, Maeda Y, Sakurai K. In Vivo. 25 229-236 2011     
  • 原著論文 Biological activity of luteolin glycosides and tricin from Sasa senanensis Rehder. Matsuta T, Sakagami H, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Kitajima M, Oizumi H, Oizumi T. In Vivo. 25 757-762 2011     
  • 原著論文 Lignin-like activity of Lentinus edodes mycelia extract (LEM). Kawano M, Sakagami H, Satoh K, Shioda S, Kanamoto T, Terakubu S, Nakashima H, Makino T. In Vivo. 24 543-551 2010     
  • 原著論文 Sulfated oligosaccharide cluster with polylysine core scaffold as a new anti-HIV dendrimer. Han S, Yoshida D, Kanamoto T, Nakashima H, Toshiyuki U, Yoshida T. Carbohydr Polym. 80 1111-1115 2010     
  • 原著論文 Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. In Vivo. 24 735-743 2010     
  • 原著論文 Contribution of lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus sanguinis. Das S, Kanamoto T, Ge X, Xu P, Unoki T, Munro CL, Kitten T. J Bacteriol. 191 4166-4179 2009     
  • 原著論文 Development of genetic tools for in vivo virulence analysis of Streptococcus sanguinis. Turner LS, Das S, Kanamoto T, Munro CL, Kitten T. Microbiology. 155 2573-2582 2009     
  • 原著論文 Antitumor potential of three herbal extracts against human oral squamous cell lines. Chu Q, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Wang Q, Sakagami H. Anticancer Res. 29 3211-3219 2009     
  • 原著論文 Comprehensive evaluation of Streptococcus sanguinis cell wall-anchored proteins in early infective endocarditis. Turner LS, Kanamoto T, Unoki T, Munro CL, Wu H, Kitten T. Infect Immun. 77 4966-4975 2009     
  • 総説 HIV感染症の現状 金本大成、中島秀喜 予防医学 50 67-72 2008     
  • 原著論文 Anti-HIV and vitamin C-synergized radical scavenging activity of cacao husk lignin fractions. Sakagami H, Satoh K, Fukamachi H, Ikarashi T, Shimizu A, Yano K, Kanamoto T, Terakubo S, Nakashima H, Hasegawa H, Nomura A, Utsumi K, Yamamoto M, Maeda Y, Osawa K. In Vivo. 22 327-332 2008     
  • 原著論文 Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract. Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S, Oizumi T. In Vivo. 22 471-476 2008     
  • 総説 治療効果にかかわるMICの理解 竹村弘、金本大成 感染と抗菌薬 10 111-115 2007     
  • 原著論文 Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions. Sakagami H, Asano K, Satoh K, Takahashi K, Kobayashi M, Koga N, Takahashi H, Tachikawa R, Tashiro T, Hasegawa A, Kurihara K, Ikarashi T, Kanamoto T, Terakubo S, Nakashima H, Watanabe S, Nakamura W. In Vivo. 21 499-505. 2007     
  • 原著論文 Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. Kanamoto T, Sato S, Nakashima H, Inoue M. J Infect Chemother. 13 353-355 2007     
  • 原著論文 Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study. Tamamura H, Omagari A, Hiramatsu K, Oishi S, Habashita H, Kanamoto T, Gotoh K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Bioorg Med Chem. 10 1417-1426 2002     
  • 総説 新しいウイルス治療薬の展望 金本大成、中島秀喜 INFECTION CONTROL 10 264-267 2001     
  • 総説 歯科診療時に注意を要するウイルス感染症?エイズ、ウイルス性肝炎? 金本大成、中島秀喜 鹿児島県歯科医師会会報  9-10 2001     
  • 総説 代替医療としての桑の実ジュースの機能性 坂上宏、小林正樹、古賀紀子、高橋仁美、立川理恵子、田代忠正、長谷川彰彦、佐藤和恵、栗原華絵子、五十嵐武、金本大成、寺久保繁美、中島秀喜、中村渡 New Food Industry 48 31-39 2001     
  • 原著論文 Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation. Kanamoto T, Kashiwada Y, Kanbara K, Gotoh K, Yoshimori M, Goto T, Sano K, Nakashima H. Antimicrob Agents Chemother. 45 1225-1230 2001     
  • 原著論文 Diverse biological activity of polycaphenol. Jiang Y, Satoh K, Aratsu C, Komatsu N, Fujimaki M, Nakashima H, Kanamoto T, Sakagami H. In Vivo. 15 145-149 2001     
  • 原著論文 Biological and genetic characterization of a human immunodeficiency virus strain resistant to CXCR4 antagonist T134. Kanbara K, Sato S, Tanuma J, Tamamura H, Gotoh K, Yoshimori M, Kanamoto T, Kitano M, Fujii N, Nakashima H. AIDS Res Hum Retroviruses. 17 615-622 2001     
  • 原著論文 Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1. Gotoh K, Yoshimori M, Kanbara K, Tamamura H, Kanamoto T, Mochizuki K, Fujii N, Nakashima H. J Infect Chemother. 7 28-36 2001     
  • 原著論文 Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Tamamura H, Omagari A, Hiramatsu K, Gotoh K, Kanamoto T, Xu Y, Kodama E, Matsuoka M, Hattori T, Yamamoto N, Nakashima H, Otaka A, Fujii N. Bioorg Med Chem Lett. 11 1897-1902 2001     
  • 原著論文 Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation. Tamamura H, Omagari A, Hiramatsu K, Kanamoto T, Gotoh K, Kanbara K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Bioorg Med Chem. 9 2179-2187 2001     
  • 原著論文 Antimicrobial activity of trifluoromethyl ketones and their synergism with promethazine. Kawase M, Motohashi N, Sakagami H, Kanamoto T, Nakashima H, Ferenczy L, Wolfard K, Miskolci C,Moln?r J. Int J Antimicrob Agents. 18 161-165 2001     
  • 原著論文 Antioxidative activity of Allium victorialis L. extracts. Shirataki Y, Motohashi N, Tani S, Sunaga K, Sakagami H, Satoh K, Nakashima H, Kanamoto T, Wolfard K, Molnar J. Anticancer Res. 21 3331-3339 2001     
  • 原著論文 Genetic heterogeneities and phenotypic characteristics of strains of the genus Abiotrophia and proposal of Abiotrophia para-adiacens sp. nov. Kanamoto T, Sato S, Inoue M. J Clin Microbiol. 38 492-498 2000     
  • 原著論文 Sulfated fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro. Gotoh K, Izumi H, Kanamoto T, Tamada Y, Nakashima H. Biosci Biotechnol Biochem. 64 1664-1670 2000     
  • 原著論文 Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Tamamura H, Omagari A, Oishi S, Kanamoto T, Yamamoto N, Peiper SC, Nakashima H, Otaka A, Fujii N. Bioorg Med Chem Lett. 10 2633-2637 2000     
  • 原著論文 Serological properties of Abiotrophia and Granulicatella species (nutritionally variant streptococci). Kitada K, Okada Y, Kanamoto T, Inoue M. Microbiol Immunol. 44 981-985 2000     
  • 原著論文 Abiotrophia elegans strains comprise 8% of the nutritionally variant streptococci isolated from the human mouth. Sato S, Kanamoto T, Inoue M. J Clin Microbiol. 37 2553-2556 1999     
  • 原著論文 Isolation and properties of bacteriolytic enzyme-producing cocci from the human mouth. Kanamoto T, Eifuku-Koreeda H, Inoue M. FEMS Microbiol Lett. 144 135-140 1996     
  • 原著論文 Genetic variation in experimental dental caries in four inbred strains of rats. Kanamoto T, Nonaka K, Nakata M. Caries Res. 28 156-160 1994     
  • 原著論文 Immunogenicity and protective effect against oral colonization by Streptococcus mutans of synthetic peptides of a streptococcal surface protein antigen. Takahashi I, Okahashi N, Matsushita K, Tokuda M, Kanamoto T, Munekata E, Russell MW, Koga T. J Immunol. 146 332-336 1991     
  • 原著論文 Intranasal immunization of mice with recombinant protein antigen of serotype c Streptococcus mutans and cholera toxin B subunit. Takahashi I, Okahashi N, Kanamoto T, Asakawa H, Koga T. Arch Oral Biol. 35 475-477 1990     
  • 原著論文 Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c. Koga T, Okahashi N, Takahashi I, Kanamoto T, Asakawa H, Iwaki M. Infect Immun. 58 289-296 1990     
  • 原著論文 Oral immunization with recombinant Streptococcus lactis carrying the Streptococcus mutans surface protein antigen gene. Iwaki M, Okahashi N, Takahashi I, Kanamoto T, Sugita-Konishi Y, Aibara K, Koga T. Infect Immun. 58 2929-2934 1990     

研究業績(学会発表等)

タブ区切りテキスト形式でダウンロード

  • ポスター発表 Amides showing antimicrobial activity against Gram-positive bacteria including MRSA and VRE T. Kanamoto, S. Terakubo, T. Miyakoshi, H. Nakashima 28th International Congress of Chemotherapy Yokohama 2013/06/05?2013/06/08 
  • 口頭発表 MRSAを含むグラム陽性菌に抗菌活性を示したアミド系化合物 金本大成、寺久保繁美、中島秀喜 第59回日本化学療法学会東日本支部総会 東京 2012/10/10?2012/10/12 
  • 口頭発表 HIVプロテアーゼ阻害能を示した低分子化合物 金本大成、寺久保繁美、浅井大輔、中島秀喜 第56回日本化学療法学会東日本支部総会 東京 2009/10/30?2009/10/31 
  • 口頭発表 細菌由来のアルギニン水解酵素によるリンパ球増殖抑制 金本大成、浅井大輔、中島秀喜 第82回日本感染症学会総会 松江市 2008/04/17?2008/04/18 

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