Akihiro Mizutani ｜教員紹介 | 薬物治療学研究室

Profile

Name: Akihiro Mizutani
Affiliation: Lab. of Pharmacotherapeutics
Subjects: ・Principles and Practice of Pathophysiology and Therapy I (1st year)
・Human Physiology (2nd year)
・Disease and Treatment I (3rd year)
・Disease and Treatment II (3rd year)
・Disease and Treatment III (4th year)
・Disease and Treatment IV (4th year)
・Principles and Practice of Pathophysiology and Therapy II (4th year)
Official title: Professor
Degree: Ph.D in Medicine

Academic background

1987　　　　Mie University School of Medicine M.D.

1992　　　　Nagoya University Graduate School of Medicine Ph.D.

Career history

1992-1994　Assistant Professor, Nagoya University School of Medicine

1994-1997　Special Postdoctoral Researcher, RIKEN

1997-2002　Research Fellow, BSI RIKEN

2002-2005　Research Fellow, Calcium Oscillation Project, ICORP

2005-2008　Assistant Professor, Institute of Medical Science University of Tokyo

2008-2011　Research Fellow, BSI RIKEN

2011-　　　 Professor, Showa Pharmaceutical University

Honors & Awards

Academic societies

Member of The Molecular Biology Society of Japan

Member of The Japan Neuroscience Society

Member of The Society for Neuroscience

Member of The Pharmaceutical Society of Japan

Research fields

・Intracellular Calcium dynamics

・Intracellular pH regulation

・Reversible protein-protein interaction regulated by post-translational modifications

・Involvement of astrocytes in synaptic plasticity and psychiatric disease

Papers

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ORIGINAL ARTICLE　Functional Significance of the C-terminal -ETTL Motif of NBCe1-C and Its Interaction with Sorting Nexin 27　Yasuaki Goto, Naomi Hasegawa, Saki Ohta, Koichi Hamada, Shingo Matsuda, Akihiro Mizutani　BPB Reports　9 (5)　170-180　2026　[Related links]
ORIGINAL ARTICLE　Activation phosphorylation and dephosphorylation dynamics of Ca2+/Calmodulin-dependent protein kinase Iα in HeLa cells　Chen Y, Miki M, Magari M, Ohtsuka S, Eto M, Ishida A, Suizu F, Mizutani A, Ando H, Mikoshiba K, Tokumitsu H　Cell Calcium　137　article number: 103183　2026　[Related links]
ORIGINAL ARTICLE　Brain region-specific and sex-dependent roles of 2-arachidonoylglycerol in the retrieval of contextual fear memory in mice.　Mizuno I, Matsuda S, Mizutani A　Neuropharmacology　300　article number: 111153　2026　[Related links]
ORIGINAL ARTICLE　Deciphering the multi-site phos-code of IRBIT underlying its binding to IP3R.　Lin Q, Yang H, Feng Q, Sumi T, Hamada K, Qian Y, Bai F, Mizutani A, Mikoshiba K.　Commun Biol　9 (1)　article number: 877　2026　[Related links]
ORIGINAL ARTICLE　Naphthyridine-Based Electron Push-Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media　Umeno T, Muroi L, Kayama Y, Usui K, Hamada K, Mizutani A, Karasawa S　Bioconjug Chem　34 (8)　1439-1446　2023　[Related links]
ORIGINAL ARTICLE　Acid responsiveness of emissive morpholinyl aminoquinolines and their use for cell fluorescence imaging　Fukumoto Y, Umeno T, Kuramochi H, Hamada K, Matsumoto S, Suzuki N, Usui K, Mizutani A, Karasawa S　Org Biomol Chem　20 (21)　4342-4351　2022　[Related links]
ORIGINAL ARTICLE　The role of the cannabinoid system in fear memory and extinction in male and female mice　Mizuno I, Matsuda S, Tohyama S, Mizutani A　Psychoneuroendocrinology　138　article number: 105688　2022　[Related links]
ORIGINAL ARTICLE　Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2　Itoh R, Hatano N, Murakami M, Mitsumori K, Kawasaki S, Wakagi T, Kanzaki Y, Kojima H, Kawaai K, Mikoshiba K, Hamada K, Mizutani A　Sci Rep　　article number: 5990　2021　[Related links]
ORIGINAL ARTICLE　Sex-dependent opposite effects of a tropomyosin-related kinase B receptor (TrkB) agonist 7,8-dihydroxyflavone on cued fear extinction in mice.　Tohyama S, Matsuda S, Mizutani A.　Neurosci. Lett.　715　134670　2020　[Related links]
ORIGINAL ARTICLE　Selective synthesis of substituted amino-quinoline derivatives by C-H activation and fluorescence evaluation of their lipophilicity-responsive properties.　Fuchi Y, Sakuma M, Ohyama K, Hagihara R, Kohno M, Hamada K, Mizutani A, Karasawa S.　Sci. Rep.　9　17723　2019　[Related links]
ORIGINAL ARTICLE　Calcineurin Binds to a Unique C-Terminal Region of NBCe1-C, the Brain Specific Isoform of NBCe1 and Enhances its Surface Expression.　Hasegawa N, Hatano N, Tohyama S, Kita S, Mikoshiba K, Mizutani A.　BPB Reports　2　7-18　2019　[Related links]
ORIGINAL ARTICLE　The Phosphatidylinositol 3-Kinase p110α/PTEN Signaling Pathway Is Crucial for HIV-1 Entry.　Hamada K, Maeda Y, Mizutani A, Okada S.　Biol. Pharm. Bull.　42　130-138　2019　
ORIGINAL ARTICLE　Sex differences in the effects of adult short-term isolation rearing on contextual fear memory and extinction.　Matsuda S, Tohyama S, Mizutani A　Neurosci. Lett.　 687　119-123　2018　
ORIGINAL ARTICLE:　Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins.　Kawaai K, Ando H, Satoh N, Yamada H, Ogawa N, Hirose M, Mizutani A, Bonneau B, Seki G, Mikoshiba K　Proc Natl Acad Sci U S A.　114　3921-392　2017　
ORIGINAL ARTICLE:　Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis.　Ogra Y, Nagasaki S, Yawata A, Anan Y, Hamada K, Mizutani A　J Toxicol Sci.　41　241-244　2016　
ORIGINAL ARTICLE:　IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation.　Kawaai K, Mizutani A, Shoji H, Ogawa N, Ebisui E, Kuroda Y, Wakana S, Miyakawa T, Hisatsune C, Mikoshiba K　Proc Natl Acad Sci U S A.　112　5515-5520　2015　
ORIGINAL ARTICLE:　IRBIT mediates synergy between Ca2+ and cAMP signaling pathways during epithelial transport in mice.　Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S　Gastroenterology. 　145　232-241　2013　
ORIGINAL ARTICLE:　Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein.　Kuroda Y, Hisatsune C, Mizutani A, Ogawa N, Matsuo K, Mikoshiba K　Mol Cell Biol.　32　2954-2963　2012　
ORIGINAL ARTICLE:　Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse.　Kabayama H, Takeuchi M, Taniguchi M, Tokushige N, Kozaki S, Mizutani A, Nakamura T, Mikoshiba K　J Neurosci.　31　7357-7364　2011　
ORIGINAL ARTICLE:　IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.　Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K　J Clin Invest.　121　956-965　2011　
ORIGINAL ARTICLE:　Isolation of Inositol 1,4,5-Trisphosphate Receptor-Associating Proteins and Selective Knockdown Using RNA Interference.　Mizutani A, Kawaai K, Hisatsune C, Ando H, Michikawa T, Mikoshiba K　Methods in Molecular Biology　645　133-141　2010　
ORIGINAL ARTICLE:　Interaction of Cupidin/Homer2 with two actin cytokeletal regulators Cdc42 small GTPase and Drebrin, in dendritic spine.　Shiraishi Y Y, Sato Y, Sakai R, Mizutani A, Knöpfel T, Mori N, Mikoshiba K, Furuichi T　BMC Neurosci. Mar 24, 　10　25　2009　
ORIGINAL ARTICLE:　Inositol 1, 4, 5-triphosphate receptor-binding protein released with Inositol 1, 4, 5-triphosphate (IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.　Kiefer H, Mizutani A, Iemura A, Natsume T, Ando H, Kuroda Y, Mikoshiba K　J Biol Chem.　284　10694-10705　2009　
ORIGINAL ARTICLE:　An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.　Ando H, Mizutani A, Mikoshiba K　J. Neurochem. 　109　539-550　2009　
ORIGINAL ARTICLE:　IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. 　Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, Mizutani A, Mikoshiba K, Muallem S　J Clin Invest.　119　193-202　2009　
ORIGINAL ARTILE:　80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity.　Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K.　J Biol Chem. 　284　372-380　2009　
ORIGINAL ARTICLE:　Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. 　Mizutani A, Kuroda Y, Futatsugi A, Furuichi T, Mikoshiba K　J. Neurosci. 28　28　5369-6382　2008　
ORIGINALARTICLE:　Activation of SAD kinase by Ca2+/calmodulin-dependent protein kinase kinase.　Fujimoto T, Yurimoto S, Hatano N, Nozaki N, Sueyoshi N, Kameshita I, Mizutani A, Mikoshiba K, Kobayashi R, Tokumitsu H　Biochemistry 47　47　4151-4159　2008　
ORIGINAL ARTICLE:　p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.　Song T, Sugimoto K, Ihara H, Mizutani A, Hatano N,Kume K, Kambe T, Yamaguchi F, Tokuda M, Watanabe Y　Biochem. J. 　401　391-398　2007　
ORIGINAL ARTICLE:　2-Aminoethyl diphenylborinate analogues: Selective inhibition for store-operated Ca2+ entry. 　Zhou H, Iwasaki H, Nakamura T, Nakamura K, Maruyama T, Hamano S, Ozaki S, Mizutani A, Mikoshiba K　Biochem. Biophys. Res.Commun.　352　277-282　2007　
ORIGINAL ARTICLE:　IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor in a phosphorylation-dependent manner. 　Ando H, Mizutani A, Kiefer H, Tsuzurugi D, Michikawa T, & Mikoshiba K　Mol. Cell 22　22　795-806　2006　
ORIGINAL ARTICLE:　IRBIT specifically binds to and activate pancreas-type Na+/HCO3- co transporter 1, pNBC.　Shirakabe K, Priori G, Yamada H, Ando H, Horita S, FujitaT, Fujimoto I, Mizutani A, Seki G, & Mikoshiba K.　Proc. Natl. Acad. Sci. USA 103　103　9542-9547　2006　
ORIGINAL ARTICLE:　Cloning of mouse type-2 and type-3 inositol 1,4,5-trisphosphate receptors and identification of a novel type-2 receptor splice variant.　Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, Inoue T, Furuichi T, Michikawa T, & Mikoshiba K　J Biol Chem.　280　10305-10317　2005　
ORIGINAL ARTICLE:　SYNCRIP, a member of the heterogeneous nuclear ribonucleoprotein family, is involved in mouse hepatitis virus RNA synthesis.　Choi KS, Mizutani A, & Lai MM　J Virol.　78　13153-13162　2004　
ORIGINAL ARTICLE:　An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites.　Bannai H, Fukatsu K, Mizutani A, Natsume T, Iemura S, Ikegami T, Inoue T, & Mikoshiba K　J Biol Chem. 　279　53427-53434,　2004　
ORIGINAL ARTICLE:　Differential expression of Homer family proteins in the developing mouse brain.　Shiraishi Y, Mizutani A, Yuasa S, Mikoshiba K, & Furuichi T　J Comp Neurol.　473　582-599　2004　
ORIGINAL ARTICLE:　Regulation of TRPC6 channel activity by tyrosine phosphorylation.　Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, & Mikoshiba K　J Biol Chem. 　279　18887-18894　2004　
ORIGINAL AICLE:　Glutamate-induced declustering of post-synaptic adaptor protein Cupidin (Homer 2/vesl-2) in cultured cerebellar granule cells. 　Shiraishi Y, Mizutani A, Yuasa S, Mikoshiba K, b& Furuichi T.　J Neurochem. 87　87　364-376　2003　
ORIGINAL ARTICLE:　Coincidence in Dendritic Clustering and Synaptic Targeting of Homer Proteins and NMDA Receptor Complex Proteins NR2B and PSD95 during Development of Cultured Hippocampal Neurons.　Shiraishi Y, Mizutani A, & Furuichi T　Mol Cell Neuroscience.　22　188-201　2003　
ORIGINAL ARTICLE:　IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor.　Ando H, Mizutani A, Matsu-ura T, & Mikoshiba K　J Biol Chem. 278　278　10602-10612　2003　
ORIGINAL ARTICLE:　Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.　Zhang S, Mizutani A, Hisatsune C, Higo T, Bannai B, Nakayama T, Hattori M, & Mikoshiba K　J Biol Chem. 278　278　4048-4056　2003　
ORIGINAL ARTICLE:　Non-polarized distribution of synaptotagmin IV in neurons: evidence that synaptotagmin IV is not a synaptic vesicle protein.　Ibata K, Hashikawa T, Tsuboi T, Terakawa S, Liang F, Mizutani A, Fukuda F, & Mikoshiba K　Neurosci. Res.　43　401-406　2002　
ORIGINAL ARTICLE:　SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.　Mizutani A, Fukuda F, Ibata K, Shiraishi Y, & Mikoshiba K　J. Biol. Chem. 　275　9823-9831　2000　
ORIGINAL ARTICLE:　Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells.　Shiraishi Y, Mizutani A, Bito H, Fujisawa K, Narumiya S, Mikoshiba K, & Furuichi T　J. Neurosci.　19　8389-8400　1999　
ORIGINAL ARTICLE:　The role of Ca2+ signaling in cell function with special reference to exocrine secretion.　Mikoshiba K, Hisatsune C, Futatsugi A, Mizutani A, Nakamura T, Miyachi K　Cornea. 　27, Suppl1　S3-8,　 2008

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Akihiro MizutaniProfessor / Ph.D in Medicine last update : 2026.09.30