Staff

Hiroshi YamazakiProfessor / PhDlast update : 2022.12.21

Profile

Name: Hiroshi Yamazaki
Affiliation: Lab. Drug Metab and Pharmacokinet
Subjects: Drug Metab and Pharmacokinet
Official title: Professor
Degree: PhD

Career history

Dr. Hiroshi Yamazaki has been Professor at Showa Pharmaceutical University, Tokyo since 2005. He received his PhD in Pharmaceutical Sciences from Osaka University and trained as a postdoctoral fellow at Vanderbilt University in 1994. He was a scientist at Osaka Prefectural Institute of Public Health from 1987-1998 and Associate Professor of Kanazawa (1998-2001) and Hokkaido (2001-2005) University. His research focuses on polymorphic cytochromes P450 and flavin-containing monooxygenases and he has authored more than 340 publications. He is an EAB member of Chemical Research in Toxicology, Biochemical Pharmacology, and British Journal of Clinical Pharmacology, Japanese Society for the Study of Xenobiotics (JSSX) fellow, and recipient of the JSSX Award.

Books

Download TSV file

月刊薬事2016年1月臨時増刊号「臨床の疑問に答えるがん薬物療法アップデート」　清水万紀子、山崎浩史　抗がん薬と薬物代謝酵素　398-407　じほう　2016　
Advances in Medicine and Biology, Vol. 93　Yamazaki, H., Chowdhury, G. and Guengerich, F.P.　Activation of Thalidomide to Reactive Metabolites by Autoinduced Human Cytochrome P450 3A Enzymes, with Substrate Cooperativity, and Implications for Development of Analogs.　23-30　Nova Science Publishers, Inc, 　2016　
「第5版衛生化学－環境と健康－」　山崎浩史　9.1.4.異物代謝の機構　355-362　丸善　2015　
「生物薬剤学改訂第3版」　山崎浩史　薬物代謝反応の過程、薬物代謝反応部位と薬物代謝酵素　95-106　南江堂　2015　
Fifty Years of Cytochrome P450 Research, ed. 　Hiroshi Yamazaki　Chapter　17 Species,Ethnic,and Individual Differences in Human Drug-Metabolizing Cytochrome P450 Enzymes　293-305　Springer　2014　
「薬物動態学第二版」　山崎浩史　第4章「代謝」　81-105　廣川書店　2014

View all

Papers

Download TSV file

[Original paper]　Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells　Sugiyama, I., Murayama, N., Kuroki, A., Kota, J., Iwano, S., Yamazaki, H., and Hirota, T　Xenobiotica　46　 765-774　2016　
[Original paper]　Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling　Shida, S. and Yamazaki, H　Xenobiotica　46　759-764　2016　
[Original paper]　Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing.　Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. 　Biopharm. Drug Dispos.　37　220-232　2016　
[Original paper]　Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. 　Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. 　Gastroenterology　150　1171-1182　2016　
[Original paper]　A new marmoset P450 4F12 enzyme expressed in small intestines and livers efficiently metabolizes an anti-histaminic drug ebastine. 　Uehara, S., Uno, Y., Yuki, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Drug Metab. Dispos.　44　833-841　2016　
[Original paper]　Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. 　Kazuki, Y., Akita, M., Kobayashi, K., Osaki, M., Satoh, D., Abe, S., Takehara, S., Kazuki, K., Yamazaki, H., Kamataki, T., and Oshimura, M. 　Sci.Rep.　6　21419　2016　
[Original paper]　Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5. Hum.　Okubo, M., Morita, S., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. 　Psychopharmacol.Clin.Exp.　31　93-102　2016　
[Original paper]　Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P450 2D6 and flavin-containing monooxygenase 3. Hum.　Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. 　Psychopharmacol.Clin.Exp.　31　83-92　2016　
[Original paper]　Molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome P450 1A1, 1A2, and 1B1.　Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos.　44　8-15　2016　
[Original paper]　Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. 　Uehara, S., Uno, Y., Inoue, T., Suzuki, T., Utoh, M., Sasaki, E., and Yamazaki, H.　Xenobiotica　46　573-578　2016　
[Original paper]　In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans. 　Sekiguchi, K., Kanazu, T., Murayama, N., Yamazaki, H., and Yamaguchi, T.　Xenobiotica　46　495-502　2016　
[Original paper]　Development of a genotyping tool for a functionally relevant CYP2C19 allele (Phe100Asn, Ala103Val, Ile112Leu) in cynomolgus macaques.　Uno, Y., Yamazaki, H.　J.Vet.Med.Sci.　78　147-148　2016　
[Original paper]　Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). 　Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. 　Xenobiotica　46　163-168　2016　
[Original paper]　Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene by human cytochrome P450 2A13. 　317. Shimada, T., Takenaka, S., Murayama, N., Kramlinger, V. M., Kim, J.-H., Kim, D., Foroozesh, M. K., Yamazaki, H., Guengerich, F. P., and Komori, M.　Xenobiotica　46　 211-224　2016　
[Review]　Meet our editorial board member　Yamazaki, H.　Curr.Drug Metab.　16　333　2015　
[Review]　19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告　山崎浩史、清水万紀子　薬剤学　75　380　2015　
[Review]　Regioselective hydroxylation of steroid hormones by human cytochromes P450.　 Niwa, T., Murayama, N., Imagawa, Y., and Yamazaki, H.　Drug Metab. Rev.　47　89-110　2015　
[Original paper]　Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. 　Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H.　Mol.Genet.Metab.Report　5　89-93　2015　
[Original paper]　Simulation of human plasma concentrations of thalidomide and primary 5-hydroxylated metabolites explored with pharmacokinetic data in humanized TK-NOG mice. 　Nishiyama, S., Suemizu, H., Shibata, N., Guengerich, F. P., and Yamazaki, H. 　Chem. Res.Toxicol.　28　2088-2090　2015　
[Original paper]　Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms.　Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H.　Data in Brief　5　 642-645　2015　
[Original paper]　Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H.　Biopharm. Drug Dispos.　36　636-643　2015　
[Original paper]　Point mutation of cytochrome P450 2A6 (a polymorphic allele CYP2A6.25) confers new substrate specificity towards flavonoids. 　Uno, T., Ogura, C., Izumi, C., Nakamura, M., Yanase, T., Yamazaki, H., Ashida, H., Kanamar, K., Yamagata, H., and Imaishi, H. 　Biopharm. Drug Dispos　36　552-563　2015　
[Original paper]　Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole.　Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos.　43　1408-1416　2015　
[Original paper]　動物データに基づくヒト放射線内部被曝線量の評価－薬物動態学的方法論の応用－　杉本倫教，岩瀬由未子，弓田長彦，千葉康司，山崎浩史，池田敏彦. 　Radioisotopes　64　673-679　2015　
[Original paper]　Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. 　Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. 　Radioisotopes　64　509-519　2015　
[Original paper]　Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. 　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Drug Metab. Dispos.　43　1119-1122　2015　
[Original paper]　Substrate selectivities and catalytic activities of marmoset liver cytochrome P450 2A6 differed from those of human P450 2A6.　Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Drug Metab. Dispos.　43　 969-976　2015　
[Original paper]　Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.　Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H.　Regul.Toxicol.Pharmacol.　72　 71-76　2015　
[Original paper]　Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. 　Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H.　Biochem. Pharmacol.　95　110-114　2015　
[Original paper]　Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.　Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H.　Xenobiotica　45　881-886　2015　
[Original paper]　Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). 　Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos. 　43　735-742　2015　
[Original paper]　Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.　Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H.　Environ. Toxicol. Pharmacol.　39　1067-1073　2015　
[Original paper]　Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan.　Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. 　Xenobiotica　45　757-765　2015　
[Original paper]　CYP2D44 polymorphisms in cynomolgus and rhesus macaques.　Uno, Y., Uehara, S., Kohara, S., Osada, N., Murayama, N., and Yamazaki,H.　Mol.Biol.Rep.　42　1149–1155　2015　
[Original paper]　Oxidation of acenaphthene and acenaphthylene by human cytochrome P450 enzymes.　Shimada, T., Takenaka, S., Murayama, N., Yamazaki, H., Kim, J. H., Kim, D., Yoshimoto, F. K., Guengerich, F. P., and Komori, M.　Chem. Res.Toxicol.　28　 268-278　2015　
[Original paper]　Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays.　Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H.　Drug Metab.Lett.　9　3-7　2015　
[Original paper]　Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. 　Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H.　Biopharm. Drug Dispos.　36　148-162　2015　
[Original paper]　Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. 　Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S.　J.Cardiovasc.Pharmacol.　65　 289-295　2015　
[Original paper]　A. Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models. 　Watanabe, Y., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Murayama, N., Sugiyama, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama　Basic Clin.Pharmacol.Toxicol.　116　468-475　2015　
[Original paper]　A. Azithromycin can prolong QT interval and suppress ventricular contraction, but will not induce Torsade de Pointes. 　Ohara, H., Nakamura, Y., Watanabe, Y., Cao, X., Yamazaki, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Yamazaki, J., Ikeda, T., and Sugiyama　Cardiovasc.Toxicol.　15　232-240　2015　
[Original paper]　Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole, and metoprolol, in cynomolgus monkeys using in vitro-in vivo correlation.　Koyanagi, T., Nakanishi, Y., Murayama, N., Yamaura, Y., Ikeda, K., Yano, K., Uehara, S., Utoh, M., Kim, S., Uno, Y., and Yamazaki, H.　Xenobiotica　45　312-321　2015　
[Original paper]　Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9. 　Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H.　Drug Metab.Pharmacokinet.　30　130-132　2015　
[Original paper]　Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.　Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. 　Drug Metab.Pharmacokinet.　30　64-69　2015　
[Original paper]　Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.　Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H.　Drug Metab.Pharmacokinet.　30　 70-74　2015　
[Original paper]　Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes.　Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H.　Clinica Chimica Acta.　441　71-74　2015　
[Original paper]　Immunochemical quantification of cynomolgus CYP2J2, CYP4A, and CYP4F enzymes in liver and small intestine.　Uehara, S., Murayama, N., Nakanshi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y.　 Xenobiotica　45　124-130　2015　
[Original paper]　Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients.　Okubo, M., Murayama, N., Miura, J., Chiba, Y., and Yamazaki, H.　Biochem. Pharmacol.　93　104-109　2015　
[Original paper]　Fluvoxamine by itself has potential to directly induce long QT syndrome at supratherapeutic concentrations.　Yamazaki-Hashimoto, Y., Nakamura, Y., Ohara, H., Cao, X., Kitahara, K., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Ikeda, T., Yamazaki, J., and Sugiyama, A.　J. Toxicol. Sci.　40　33-42　2015　
[Original paper]　Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase.　Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Drug Metab. Dispos.　43　27-33　2015　
[Original paper]　Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver.　Yamazaki, H., Kuribayashi, S., Inoue, T., Honda, T., Tateno, C., Oofusa, K., Ninomiya, S., Ikeda, T., Izumi, T., and Horie, T.　Toxicol.Res.　4　106-111　2015　
[Review]　Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450.　Niwa, T., Inagawa, Y., and Yamazaki, H.　Curr.Drug Metab.　15　651-678　2014　
[Review]　平成26年度日本薬物動態学会学会賞を受賞して　山崎浩史　Drug Metab.Pharmacokinet.　29(6)　15-17　2014　
[Review]　私立薬大での薬物動態学研究室の立ち上げ(2)　山崎浩史　Drug Metab.Pharmacokinet.　29(6)　39-42　2014　
[Review]　私立薬大での薬物動態学研究室の立ち上げ(1)　山崎浩史　Drug Metab.Pharmacokinet.　29(5)　21-24　2014　
[Review]　Drug-induced liver toxicity studies: research into human metabolites clarifies their role in drug development. 　Yamazaki, H. 　Drug Metab.Pharmacokinet.　29　111　2014　
[Original paper]　Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans.　Sakai, C., Iwano, S., Yamazaki, Y., Ando, Y., Nakane, F., Kouno, M., Yamazaki, H., and Miyamoto, Y. 　J. Drug Metab.Toxicol.　5　173　2014　
[Original paper]　Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1, and CYP51A1 in cynomolgus macaques. 　Uno, Y., Hosaka, S., and Yamazaki, H.　J.Vet.Med.Sci.　76　1647-1650　2014　
[Original paper]　Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation.　Niwa T, Yasumura M, Murayama N and Yamazaki H.　Drug Metab.Lett.　8　43-50　2014　
[Original paper]　Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. 　Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H.　Regul.Toxicol.Pharmacol.　70　468-473　2014　
[Original paper]　CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. 　Uno, Y., Matsushita, A., Shukuya, M., Matsumoto, Y., Murayama, N., and Yamazaki, H. 　Biochem. Pharmacol.　91　 242-248　2014　
[Original paper]　Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.　Uno, Y., Uehara, S., Kohara, S., Murayama, N., and Yamazaki, H.　Drug Metab. Dispos.　42　1407-1410　2014　
[Original paper]　Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. 　Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H.　Regul.Toxicol.Pharmacol. 　70　214-221　2014　
[Original paper]　Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing.　Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H.　PLoS One　9　e100936　2014　
[Original paper]　Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.　Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H.　Biochem. Pharmacol.　90　159-165　2014　
[Original paper]　Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. 　Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H.　Clin.Kidney J.　7　329　2014　
[Original paper]　A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)　Ohyama, K., Shimizu, M., and Yamazaki, H.　Jpn. J. Pharm. Health Care Sci.　40　310-316　2014　
[Original paper]　K. Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 Inhibitor teneligliptin: an open-label study in healthy white subjects in Germany.　Nakamaru, Y., Hayashi, Y., Sekine, M., Kinoshita, S., Thompson, J., Kawaguchi, A., Davies, M., Jurgen, Heuer H., Yamazaki, H., and Akimoto　Clin.Ther.　36　760-769　2014　
[Original paper]　Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig. Biopharm.　Higashi, E., Ando, A., Iwano, S., Murayama, N., Yamazaki, H., and Miyamoto, S. 　Drug Dispos.　35　313-320　2014　
[Original paper]　Koyanagi, T., Yamaura, K., Yano, K., Kim, S., and Yamazaki, H. 　Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.　Xenobiotica　44　893-901　2014　
[Original paper]　Yajima, K., Uno, Y., Murayama, N., Uehara, S., Shimizu, M., Nakamura, C., Iwasaki, K., Utoh, M., and Yamazaki, H.　Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. 　Drug Metab. Dispos　42　867-871　2014　
[Original paper]　Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys.　Uehara, S., Murayama, N., Nakanishi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y.　Xenobiotica　44　769-774　2014　
[Original paper]　Voriconazole metabolism, toxicity and the effect of cytochrome P450 2C19 genotype. 　Zonios, D., Yamazaki, H., Murayama, N., Natrarajan, V., Palmore, T., Childs, R., Skinner, J., and Bennett, J.　J.Infect.Dis.　209　1941-1948　2014　
[Original paper]　Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.　Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R.　Brit.J. Clin. Pharmacol.　77　839-851　2014　
[Original paper]　Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor.　Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H.　Chem. Res.Toxicol.　27　304-308　2014　
[Original paper]　Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans.　264. Nakamaru, Y., Hayashi, Y., Ikegawa, R., Kinoshita, S., Madera, B. P., Gunput, D., Kawaguchi, A., Davies, M., Mair, S., Yamazaki, H., Kume, T., and Suzuki, M.　Xenobiotica　44　242-253　2014　
[Original paper]　Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. 　Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H.　Xenobiotica　44　10-16　2014　
[Original paper]　Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analog of thalidomide.　Chowdhury G, Shibata N, Yamazaki H., and Guengerich FP.　Chem. Res.Toxicol.　27　147-156　2014　
[Original paper]　The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice.　Higuchi, Y., Kawai, K., Yamazaki, H., Nakamura, M., Bree, F., Guillouzo, C., and Suemizu, H. 　Xenobiotica　44　146-153　2014

View all

Conference, etc.

Download TSV file

[Special lecture/Symposium]　Representative phthalate pharmacokinetics in chimeric mice with humanized liver　Hiroshi Yamazaki　Green Plasticizer Development Forum 2016　Shanghai　2016/04/23～2016/04/25
[Poster presentation]　抗てんかん薬オクスカルバゼピンの代謝酵素誘導能に関する研究　黒木彩加、村山典恵、杉山育男、岩野俊介、山崎浩史、廣田孝司　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　向精神病薬カルバマゼピンがもたらすヒトP4503A酵素との薬物相互作用　村山典恵、倉林優貴、日川美紀子、大久保真穂、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　日本人におけるトリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3ハプロタイプの解析　牧野美紀、清水万紀子、徳山瑛美、梶谷綾、渡邊碧、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　日本人におけるトリメチルアミン尿症の原因となる新規フラビン含有モノオキシゲナーゼ3遺伝子変異の解析　徳山瑛美、清水万紀子、牧野美紀、梶谷綾、渡邊碧、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　ヒト肝細胞移植マウスおよびマーモセット生理学的薬物動態モデルを活用したチトクロムP450カクテル基質のヒト血中濃度推移予測　清水万紀子、三井満里奈、河野未来、上原正太郎、宇野泰広、鵜藤雅裕、井上貴史、佐々木えりか、末水洋志、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　新規マーモセットP450 2J酵素の同定および機能解析　上原正太郎、岡本絵里子、宇野泰広、井上貴史、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Oral presentation]　マーモセット肝のワルファリン酸化的代謝の立体選択性　河野未来、上原正太郎、石井さくら、宇野泰広、井上貴史、鵜藤雅裕、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　マーモセットあるいはカニクイザル肝細胞を用いた薬物暴露によるチトクロムP450誘導の評価　鈴木貴子、上原正太郎、村山典恵、宇野泰広、矢島加奈子、鵜藤雅裕、井上貴史、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　マーモセットおよびカニクイザル小腸P450酵素によるエバスチン酸化的代謝　上原正太郎、結城友香子、宇野泰広、井上貴史、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
[Poster presentation]　An Association between Plasma and Urinary Levels of Trimethylamine-N-oxide(TMAO) and Metabolic Factors in a Population of Community-dwelling Japanese.　Ako Fukami, Hisashi Adachi, Mika Enomoto, Eita Kumagai, Sachiko Nakamura, Yume Nohara, Erika Nakao, Nagisa Morikawa, Tomoko Tsuru, Hiroshi Yamazaki, Kei Fukami, and Yoshihiro Fukumoto　第80回日本循環器学会学術集会　仙台　2016/03/18～2016/03/20
[Special lecture/Symposium]　ヒト放射線内部被曝線量評価の実際およびAPDDの提案　池田敏彦、村山典恵、山崎浩史　北里-APDD合同シンポジウム　－ヒトRI試験の実施指針－　東京　2016/03/14
[Special lecture/Symposium]　薬物代謝酵素の多型と代謝物に民族差を生ずる可能性-日本人におけるヒトRI試験の重要性- 　山崎浩史　北里-APDD合同シンポジウム　－ヒトRI試験の実施指針－　東京　2016/03/14
[Poster presentation]　In Vivo Model for Predicting Organophosphate Toxicity using Humanized-Liver TK-NOG Mouse　Hiroshi Suemizu, Miyuki Kuronuma, Kenji Kawai, Norie Murayama, Masato Nakamura and Hiroshi Yamazaki　The Society of Toxicology 55th Annual Meeting　New Orleans, USA　2016/03/13～2016/03/17
[Oral presentation]　ニコチン代謝酵素チトクロム P450 2A6 野生型および全欠損型遺伝子判定法の比較　岸本いずみ、清水万紀子、梶谷綾、山崎浩史　第70回聖マリアンナ医科大学医学会学術集会　川崎　2016/03/12
[Special lecture/Symposium]　Metabolic Activation of Xenobiotics by Polymorphic Drug-metabolizing Enzymes　Hiroshi Yamazaki　The 13th Asia Pacific Federation of Pharmacologist Meeting (APFP)　Thailand　2016/02/01～2016/02/03
[Special lecture/Symposium]　ヒト薬物動態予測を目指したサル、マーモセットとヒト肝細胞移植マウスの活用研究　山崎浩史　第38 回薬物動態談話会年会　浜松　2015/11/30～2015/12/01
[Poster presentation]　腎機能障害時における薬物間相互作用の予測：DPP-4阻害薬テネリアを例として　清水秀俊、仲丸善喜、山崎浩史、久米俊行　第25回日本医療薬学会年会　横浜　2015/11/21～2015/11/23
[Special lecture/Symposium]　Comparison of drug oxidations in humans, primates, and rodents　Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Special lecture/Symposium]　Flavin-containing monooxygenase 3: Individual differences and drug interactions　Makiko Shimizu and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes　Yuichiro Higuchi, Kenji Kawai, Tatsuro Kanaki, Hiroshi Yamazaki, Chesne Cristophe, Guguen-Guillouzo Christiane, Hiroshi Suemizu　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Pharmacokinetics of efavirenz after oral and intravenous administration of efavirenz to genotypedcynomolgus monkeys　Yusuke Kitsugi, Kanami Ikeda, Atsushi Matsuoka, Takaaki Tokunaga, Natsumi Tomida, Haruka Shirosawa, Takahiro Yoshikawa, Yasuhiro Uno, Kazuhide Iwasaki, Masahiro Utoh, Hiroshi Yamazaki, Shinya Hosaka　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Comparison of catalytic properties in cytochrome P450 3A4 and 3A5 for various compounds including　endogenous steroid hormones by molecular docking simulation　Toshiro Niwa, Norie Murayama, Yurie Imagawa, Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Time-dependent inhibition of OATP-mediated transport by cyclosporine A is reproduced in cynomolgus monkeys　Tsuyoshi Takahashi, Tatsuyuki Ohtsuka, Yasuhiro Uno, Hiroshi Yamazaki, Toshiyuki Kume　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Induction of drug metabolizing enzymes by thalidomide dependent on pregnane X receptor (PXR) in human livers as evident using PXR-knockout HepaRG cells　Norie Murayama, Kanako Yajima, and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Analysis of cytochrome P450 regulators in cynomolgus macaque　Yasuhiro Uno and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
[Poster presentation]　Cytochrome P450-dependent warfarin and caffeine metabolism in marmosets, monkeys, and humans　Hiroshi Yamazaki, Shotaro Uehara, Yasuhiro Uno, and Erika Sasaki　20th North American ISSX Meeting　Orlando, USA　2015/10/18～2015/10/22
[Poster presentation]　マーモセット肝のワルファリン代謝の解析　河野未来、上原正太郎、宇野泰広、鵜藤雅裕、佐々木えりか、山崎浩史　第59回日本薬学会関東支部大会　東京　2015/09/12
[Poster presentation]　マーモセット肝のカフェイン代謝経路の解析　鈴木貴子、上原正太郎、宇野泰広、鵜藤雅裕、佐々木えりか、山崎浩史　第59回日本薬学会関東支部大会　東京　2015/09/12
[Special lecture/Symposium]　Human Drug Metabolism by Cytochrome P450 Enzymes　Hiroshi Yamazaki　2nd Symposium of SPU Innovative Project for Pharmaceutical Analyses of Covalent Modification in Biomolecules　東京　2015/09/01
[Special lecture/Symposium]　カニクイザルにおけるチトクロムP450とグルクロン酸転移酵素の解析　宇野泰広、山崎浩史　第42回日本毒性学会学術集会　金沢　2015/06/29～2015/07/01
[Special lecture/Symposium]　実験動物およびヒトの薬物酸化酵素活性の比較　山崎浩史、宇野泰広　第42回日本毒性学会学術集会　金沢　2015/06/29～2015/07/01
[Oral presentation]　日本人のトリメチルアミン尿症に関する大規模調査　千葉布季子、清水万紀子、牧野美紀、三觜菜々子、友田沙也加、山崎浩史　第69回聖マリアンナ医科大学医学会学術集会　川崎　2015/06/27
[Oral presentation]　血液透析患者におけるFMD値とtrimethylamine-N-oxide、心血管病変との検討　西谷光広、上出亜希子、後藤厚子、武田麻有里、寺中久代、森内則子、山森満寿美、保志場紀子、澤﨑真由美、上田律子、大門正一郎、清水万紀子、山崎浩史　第60回日本透析医学会学術集会　横浜　2015/06/26～2016/06/28
[Poster presentation]　当クリニックにおける魚臭症候群の一例を経験して　森内則子、西谷光広、澤﨑真由美、保志場紀子、山森満寿美、寺中久代、武田麻有里、後藤厚子、上出亜希子、上田律子、大門正一郎、清水万紀、山崎浩史　第60回日本透析医学会学術集会　横浜　2015/06/26～2016/06/28
[Poster presentation]　Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C enzymes　Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Poster presentation]　Human cytochromes P450-mediated regioselective hydroxylation of steroid hormones　Toshiro Niwa, Norie Murayama, Yurie Imagawa, and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Poster presentation]　Identification and analysis of CYP2B6 variants in cynomolgus and rhesus macaques　Yasuhiro Uno, Shotaro Uehara, and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Poster presentation]　Molecular cloning, expression and functional characterization of marmoset cytochrome P450 2A6 　Shotaro Uehara, Yasuhiro Uno, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Poster presentation]　Mutations of flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria　Makiko Shimizu and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Poster presentation]　The modulation of physiological condition for expression of P450s in differential cryopreserved HepaRG cells　Norie Murayama, Kanako Yajima, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Poster presentation]　In Vivo R/S-Warfarin Metabolism Mediated by Polymorphic P450 2C19 in Cynomolgus Monkeys　Masahiro Utoh, Takahiro Yoshikawa, Makiko Shimizu, Kazuhide Iwasaki, Yasuhiro Uno, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
[Special lecture/Symposium]　多型と麻酔薬の体内動態　山崎浩史　日本麻酔科学会第62 回学術集会　神戸　2015/05/28～2015/05/30
[Poster presentation]　薬物代謝型cytochrome P450及びステロイド代謝酵素によるステロイド代謝　丹羽俊朗、村山典恵、今川友里恵、山崎浩史　日本薬剤学会第30年会　長崎　2015/05/21～2015/05/23
[Poster presentation]　Cytochrome P450 (CYP、P450) 3A4及びCYP3A5を含むヒト代謝型P450に対する各種抗真菌薬の相互作用　今川友里恵、村山典恵、山崎浩史、丹羽俊朗　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Poster presentation]　Cytochrome P450 (CYP、P450) 3A4及びCYP3A5を含む各種ヒトP450によるステロイド代謝　丹羽俊朗、村山典恵、今川友里恵、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Poster presentation]　カニクイザル生理学的薬物動態モデルを活用したチトクロム P450 カクテル基質のヒト血中濃度推移予測　志田聡美、村山典恵、清水万紀子、鵜藤雅裕、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Oral presentation]　サリドマイド 1 次および 2 次酸化的代謝に関与するチトクロム P450 の種差　西山咲弥子、清水万紀子、上原正太郎、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Poster presentation]　日本人トリメチルアミン尿症の大規模詳細調査　千葉布季子、清水万紀子、徳山瑛美、牧野美紀、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Oral presentation]　サリドマイドによるヒトP450酵素自己誘導機構に及ぼす要因　村山典恵、矢島加奈子、柴田哲男、鵜藤雅裕、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Oral presentation]　カニクイザルシトクロムP450 2C9の基質特異性に関する検討　保坂信哉、村山典恵、薩川正広、上原正太郎、清水万紀子、岩﨑一秀、岩野俊介、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Oral presentation]　チトクロム P450 2A6 野生型と全欠損型遺伝子の迅速判定法　清水万紀子、岸本いずみ、小山智生、澤谷怜、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Poster presentation]　抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差　大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也、清水万紀子、秋元洋一、後藤晶子、○山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Oral presentation]　抗精神病薬リスペリドン投与日本人患者における血漿中薬物濃度の個人差　大久保真穂、村山典恵、森田翔子、森亜沙美、倉林優貴、秋元洋一、後藤晶子、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
[Special lecture/Symposium]　マーモセット、カニクイザルおよびヒトの薬物酸化酵素活性の比較　山崎浩史、上原正太郎、宇野泰広　第4回日本マーモセット研究会大会　犬山　2015/01/22～2015/01/23
[Oral presentation]　日本人のトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3遺伝子変異の解析　伊熊鞠佳、清水万紀子、三觜菜々子、友田沙也加、山崎浩史　第68回聖マリアンナ医科大学医学会学術集会　川崎　2014/12/11～2014/12/12
[Oral presentation]　レボカルニチン製剤を使用した透析患者の血中トリメチルアミン濃度　山崎浩史、清水万紀子、小篠榮　第35回日本臨床薬理学会年会　松山　2014/12/04～2014/12/06
[Oral presentation]　日本人集団から見出されたトリメチルアミン尿症の原因となるフラビン含有酸素添加酵素3遺伝子多型　清水万紀子、折口裕美、伊熊鞠佳、三觜菜々子、友田沙也加、山崎浩史　第35回日本臨床薬理学会年会　松山　2014/12/04～2014/12/06
[Poster presentation]　Comparison of pharmacokinetics parameters of cytochrome P450 probe substrates in humans, mice, rats, dogs, monkeys, and microminipigs　Chizuka Sakai, Shunsuke Iwano, Yuri Yamazaki, Akihiro Ando, Hiroshi Yamazaki, Yohei Miyamoto　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Poster presentation]　Warfarin metabolism mediated by polymorphic P450 2C19 in cynomolgus monkeys　Hiroshi Yamazaki, Yasuhiro Uno, Mitsunori Shukuya, Takahiro Yoshikawa, Yasuka Matsumoto, Akinori Matsushita, Norie Murayama, Koichiro Fukuzaki, Masahiro Utoh　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Poster presentation]　Genetic polymorphisms in flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population　Makiko Shimizu, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Poster presentation]　Roles of auto-induction of human P450 3A enzymes involved in the teratogenicity of thalidomide　Norie Murayama, Christophe Chesné, F. Peter Guengerich, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Poster presentation]　Oxidative metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by liver and brain microsomes from common marmosets　Shotaro Uehara, Norie Murayama, Makiko Shimizu, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Poster presentation]　Effects of CYP2D6 and CYP3A5 genotypes and co-administrated drugs on the metabolic　clearance of antidepressant mirtazapine　Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Special lecture/Symposium]　Metabolic activation and fate of xenobiotics determined by polymorphic drug-metabolizing enzymes.　Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Special lecture/Symposium]　Reactive metabolite formation of drugs by human P450s in chimeric mice with humanized liver.　Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
[Poster presentation]　レボカルニチン投与時の透析患者におけるトリメチルアミンおよび N -酸化体の体内運命の検討　小泉綾乃、若林あかり、清水万紀子、小篠榮、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
[Poster presentation]　抗うつ薬ミルタザピンの代謝消失に関わる薬物代謝酵素　森亜沙美、大久保真穂、成田桃子、森田翔子、村山典恵、三浦淳、千葉泰二、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
[Oral presentation]　サリドマイド代謝的活性化における霊長類チトクロム P450 の役割　西山咲弥子、清水万紀子、上原正太郎、宇野泰広、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
[Poster presentation]　ヒト肝移植マウスを活用した生理学的薬物動態モデルによるフタル酸ビス２エチルヘキシルのヒト体内動態予測　安達昂一郎、宮口貴守、村山典恵、末水洋志、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
[Poster presentation]　薬局の大規模データを用いたジクロフェナク局所皮膚適用製剤の副作用発現とリスク因子に関する検討　大山勝宏、高橋真二、福岡勝志、清水万紀子、山崎浩史　第24回日本医療薬学会年会　名古屋　2014/09/27～2014/09/28
[Poster presentation]　Drug interaction of antifungal agents against cytochrome P450s　Toshiro Niwa, Yurie Imagawa, Motohiro Yasumura, Norie Murayama, Hiroshi Yamazaki　12th International Symposium on Cytochrome P450 Biodiversity & Biotechnology　京都　2014/09/24～2014/09/28
[Oral presentation]　ヒト肝細胞HepaRGにおける環境化学物質の細胞毒性と薬物代謝酵素誘導能について　曽根秀子、村山典恵、王文龍、曾洋、南齋ひろ子、曾勤、山崎浩史　フォーラム2014　衛生薬学・環境トキシコロジー　つくば　2014/09/19～2014/09/20
[Oral presentation]　カニクイザル硫酸転移酵素の同定・解析　宇野泰広、村山典恵、山崎浩史　第157回日本獣医学会学術集会　札幌　2014/09/09～2014/09/12
[Oral presentation]　代謝酵素遺伝子多型および併用薬が抗うつ薬ミルタザピンの代謝消失に及ぼす影響　森田翔子、大久保真穂、森亜沙美、村山典恵、三浦淳、千葉泰二、山崎浩史　第67回聖マリアンナ医科大学医学会学術集会　川崎　2014/07/10～2014/07/11
[Special lecture/Symposium]　安全性評価を支える薬物動態試験のあり方　山崎浩史　第41回日本毒性学会学術集会　神戸　2014/07/02～2014/07/04
[Poster presentation]　カニクイザルの小腸におけるUDP-グルクロン酸転移酵素活性の性差、産地差および部位差　中西康晴、中村稚加、岩崎一秀、鵜藤雅裕、山崎浩史、宇野泰広　第41回日本毒性学会学術集会　神戸　2014/07/02～2014/07/04
[Special lecture/Symposium]　レボカルニチンを使う透析患者さんの体臭を科学する－個の医療－　山崎浩史　医療薬学フォーラム2014／第22回クリニカルファーマシーシンポジウム　東京　2014/06/28～2014/06/29
[Poster presentation]　透析患者のレボカルニチン（LC）投与時における内服薬と注射薬の血中トリメチルアミン（TMA）及びN-酸化体（TMAO）値への影響　小篠榮、前田弘美、井戸田昭子、久保和雄、鈴木敦、鈴木利昭、小泉綾乃、若林あかり、清水万紀子、山崎浩史　第59回日本透析医学会学術集会・総会　神戸　2014/06/13～2014/06/15
[Poster presentation]　各種cytochrome P450に対する抗真菌薬の相互作用　丹羽俊朗、今川友里恵、山崎浩史　日本薬剤学会第29年会　さいたま　2014/05/20～2014/05/22

View all