種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL "[Original paper]" "Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells" "Sugiyama, I., Murayama, N., Kuroki, A., Kota, J., Iwano, S., Yamazaki, H., and Hirota, T" Xenobiotica 46 " 765-774" 2016 "[Original paper]" "Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling" "Shida, S. and Yamazaki, H" Xenobiotica 46 759-764 2016 "[Original paper]" "Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing." "Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. " "Biopharm. Drug Dispos." 37 220-232 2016 "[Original paper]" "Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. " "Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. " Gastroenterology 150 1171-1182 2016 "[Original paper]" "A new marmoset P450 4F12 enzyme expressed in small intestines and livers efficiently metabolizes an anti-histaminic drug ebastine. " "Uehara, S., Uno, Y., Yuki, Y., Inoue, T., Sasaki, E., and Yamazaki, H." "Drug Metab. Dispos." 44 833-841 2016 "[Original paper]" "Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. " "Kazuki, Y., Akita, M., Kobayashi, K., Osaki, M., Satoh, D., Abe, S., Takehara, S., Kazuki, K., Yamazaki, H., Kamataki, T., and Oshimura, M. " Sci.Rep. 6 21419 2016 "[Original paper]" "Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5. Hum." "Okubo, M., Morita, S., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. " Psychopharmacol.Clin.Exp. 31 93-102 2016 "[Original paper]" "Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P450 2D6 and flavin-containing monooxygenase 3. Hum." "Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. " Psychopharmacol.Clin.Exp. 31 83-92 2016 "[Original paper]" "Molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome P450 1A1, 1A2, and 1B1." "Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 44 8-15 2016 "[Original paper]" "Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. " "Uehara, S., Uno, Y., Inoue, T., Suzuki, T., Utoh, M., Sasaki, E., and Yamazaki, H." Xenobiotica 46 573-578 2016 "[Original paper]" "In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans. " "Sekiguchi, K., Kanazu, T., Murayama, N., Yamazaki, H., and Yamaguchi, T." Xenobiotica 46 495-502 2016 "[Original paper]" "Development of a genotyping tool for a functionally relevant CYP2C19 allele (Phe100Asn, Ala103Val, Ile112Leu) in cynomolgus macaques." "Uno, Y., Yamazaki, H." J.Vet.Med.Sci. 78 147-148 2016 "[Original paper]" "Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). " "Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. " Xenobiotica 46 163-168 2016 "[Original paper]" "Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene by human cytochrome P450 2A13. " "317. Shimada, T., Takenaka, S., Murayama, N., Kramlinger, V. M., Kim, J.-H., Kim, D., Foroozesh, M. K., Yamazaki, H., Guengerich, F. P., and Komori, M." Xenobiotica 46 " 211-224" 2016 [Review] "Meet our editorial board member" "Yamazaki, H." "Curr.Drug Metab." 16 333 2015 [Review] "19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告" 山崎浩史、清水万紀子 薬剤学 75 380 2015 [Review] "Regioselective hydroxylation of steroid hormones by human cytochromes P450." " Niwa, T., Murayama, N., Imagawa, Y., and Yamazaki, H." "Drug Metab. Rev." 47 89-110 2015 "[Original paper]" "Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. " "Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H." Mol.Genet.Metab.Report 5 89-93 2015 "[Original paper]" "Simulation of human plasma concentrations of thalidomide and primary 5-hydroxylated metabolites explored with pharmacokinetic data in humanized TK-NOG mice. " "Nishiyama, S., Suemizu, H., Shibata, N., Guengerich, F. P., and Yamazaki, H. " "Chem. Res.Toxicol." 28 2088-2090 2015 "[Original paper]" "Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms." "Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H." "Data in Brief" 5 " 642-645" 2015 "[Original paper]" "Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances." "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H." "Biopharm. Drug Dispos." 36 636-643 2015 "[Original paper]" "Point mutation of cytochrome P450 2A6 (a polymorphic allele CYP2A6.25) confers new substrate specificity towards flavonoids. " "Uno, T., Ogura, C., Izumi, C., Nakamura, M., Yanase, T., Yamazaki, H., Ashida, H., Kanamar, K., Yamagata, H., and Imaishi, H. " "Biopharm. Drug Dispos" 36 552-563 2015 "[Original paper]" "Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole." "Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 43 1408-1416 2015 "[Original paper]" 動物データに基づくヒト放射線内部被曝線量の評価－薬物動態学的方法論の応用－ "杉本倫教， 岩瀬由未子，弓田長彦，千葉康司，山崎浩史，池田敏彦. " Radioisotopes 64 673-679 2015 "[Original paper]" "Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. " "Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. " Radioisotopes 64 509-519 2015 "[Original paper]" "Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 1119-1122 2015 "[Original paper]" "Substrate selectivities and catalytic activities of marmoset liver cytochrome P450 2A6 differed from those of human P450 2A6." "Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H." "Drug Metab. Dispos." 43 " 969-976" 2015 "[Original paper]" "Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling." "Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H." Regul.Toxicol.Pharmacol. 72 " 71-76" 2015 "[Original paper]" "Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. " "Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 95 110-114 2015 "[Original paper]" "Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling." "Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H." Xenobiotica 45 881-886 2015 "[Original paper]" "Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). " "Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos. " 43 735-742 2015 "[Original paper]" "Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling." "Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H." "Environ. Toxicol. Pharmacol." 39 1067-1073 2015 "[Original paper]" "Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan." "Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. " Xenobiotica 45 757-765 2015 "[Original paper]" "CYP2D44 polymorphisms in cynomolgus and rhesus macaques." "Uno, Y., Uehara, S., Kohara, S., Osada, N., Murayama, N., and Yamazaki,H." Mol.Biol.Rep. 42 1149–1155 2015 "[Original paper]" "Oxidation of acenaphthene and acenaphthylene by human cytochrome P450 enzymes." "Shimada, T., Takenaka, S., Murayama, N., Yamazaki, H., Kim, J. H., Kim, D., Yoshimoto, F. K., Guengerich, F. P., and Komori, M." "Chem. Res.Toxicol." 28 " 268-278" 2015 "[Original paper]" "Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays." "Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H." "Drug Metab.Lett." 9 3-7 2015 "[Original paper]" "Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. " "Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H." "Biopharm. Drug Dispos." 36 148-162 2015 "[Original paper]" "Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. " "Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S." J.Cardiovasc.Pharmacol. 65 " 289-295" 2015 "[Original paper]" "A. Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models. " "Watanabe, Y., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Murayama, N., Sugiyama, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama" "Basic Clin.Pharmacol.Toxicol." 116 468-475 2015 "[Original paper]" "A. Azithromycin can prolong QT interval and suppress ventricular contraction, but will not induce Torsade de Pointes. " "Ohara, H., Nakamura, Y., Watanabe, Y., Cao, X., Yamazaki, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Yamazaki, J., Ikeda, T., and Sugiyama" Cardiovasc.Toxicol. 15 232-240 2015 "[Original paper]" "Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole, and metoprolol, in cynomolgus monkeys using in vitro-in vivo correlation." "Koyanagi, T., Nakanishi, Y., Murayama, N., Yamaura, Y., Ikeda, K., Yano, K., Uehara, S., Utoh, M., Kim, S., Uno, Y., and Yamazaki, H." Xenobiotica 45 312-321 2015 "[Original paper]" "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9. " "Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 130-132 2015 "[Original paper]" "Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans." "Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. " "Drug Metab.Pharmacokinet." 30 64-69 2015 "[Original paper]" "Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers." "Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 " 70-74" 2015 "[Original paper]" "Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes." "Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H." "Clinica Chimica Acta." 441 71-74 2015 "[Original paper]" "Immunochemical quantification of cynomolgus CYP2J2, CYP4A, and CYP4F enzymes in liver and small intestine." "Uehara, S., Murayama, N., Nakanshi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y." " Xenobiotica" 45 124-130 2015 "[Original paper]" "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." "Okubo, M., Murayama, N., Miura, J., Chiba, Y., and Yamazaki, H." "Biochem. Pharmacol." 93 104-109 2015 "[Original paper]" "Fluvoxamine by itself has potential to directly induce long QT syndrome at supratherapeutic concentrations." "Yamazaki-Hashimoto, Y., Nakamura, Y., Ohara, H., Cao, X., Kitahara, K., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Ikeda, T., Yamazaki, J., and Sugiyama, A." "J. Toxicol. Sci." 40 33-42 2015 "[Original paper]" "Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase." "Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 27-33 2015 "[Original paper]" "Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver." "Yamazaki, H., Kuribayashi, S., Inoue, T., Honda, T., Tateno, C., Oofusa, K., Ninomiya, S., Ikeda, T., Izumi, T., and Horie, T." Toxicol.Res. 4 106-111 2015 [Review] "Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450." "Niwa, T., Inagawa, Y., and Yamazaki, H." "Curr.Drug Metab." 15 651-678 2014 [Review] 平成26年度日本薬物動態学会学会賞を受賞して 山崎浩史 "Drug Metab.Pharmacokinet." 29(6) 15-17 2014 [Review] 私立薬大での薬物動態学研究室の立ち上げ(2) 山崎浩史 "Drug Metab.Pharmacokinet." 29(6) 39-42 2014 [Review] 私立薬大での薬物動態学研究室の立ち上げ(1) 山崎浩史 "Drug Metab.Pharmacokinet." 29(5) 21-24 2014 [Review] "Drug-induced liver toxicity studies: research into human metabolites clarifies their role in drug development. " "Yamazaki, H. " "Drug Metab.Pharmacokinet." 29 111 2014 "[Original paper]" "Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans." "Sakai, C., Iwano, S., Yamazaki, Y., Ando, Y., Nakane, F., Kouno, M., Yamazaki, H., and Miyamoto, Y. " "J. Drug Metab.Toxicol." 5 173 2014 "[Original paper]" "Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1, and CYP51A1 in cynomolgus macaques. " "Uno, Y., Hosaka, S., and Yamazaki, H." J.Vet.Med.Sci. 76 1647-1650 2014 "[Original paper]" "Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation." "Niwa T, Yasumura M, Murayama N and Yamazaki H." "Drug Metab.Lett." 8 43-50 2014 "[Original paper]" "Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. " "Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H." Regul.Toxicol.Pharmacol. 70 468-473 2014 "[Original paper]" "CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. " "Uno, Y., Matsushita, A., Shukuya, M., Matsumoto, Y., Murayama, N., and Yamazaki, H. " "Biochem. Pharmacol." 91 " 242-248" 2014 "[Original paper]" "Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism." "Uno, Y., Uehara, S., Kohara, S., Murayama, N., and Yamazaki, H." "Drug Metab. Dispos." 42 1407-1410 2014 "[Original paper]" "Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. " "Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H." "Regul.Toxicol.Pharmacol. " 70 214-221 2014 "[Original paper]" "Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing." "Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H." "PLoS One" 9 e100936 2014 "[Original paper]" "Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs." "Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 90 159-165 2014 "[Original paper]" "Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. " "Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H." "Clin.Kidney J." 7 329 2014 "[Original paper]" "A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)" "Ohyama, K., Shimizu, M., and Yamazaki, H." "Jpn. J. Pharm. Health Care Sci." 40 310-316 2014 "[Original paper]" "K. Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 Inhibitor teneligliptin: an open-label study in healthy white subjects in Germany." "Nakamaru, Y., Hayashi, Y., Sekine, M., Kinoshita, S., Thompson, J., Kawaguchi, A., Davies, M., Jurgen, Heuer H., Yamazaki, H., and Akimoto" Clin.Ther. 36 760-769 2014 "[Original paper]" "Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig. Biopharm." "Higashi, E., Ando, A., Iwano, S., Murayama, N., Yamazaki, H., and Miyamoto, S. " "Drug Dispos." 35 313-320 2014 "[Original paper]" "Koyanagi, T., Yamaura, K., Yano, K., Kim, S., and Yamazaki, H. " "Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs." Xenobiotica 44 893-901 2014 "[Original paper]" "Yajima, K., Uno, Y., Murayama, N., Uehara, S., Shimizu, M., Nakamura, C., Iwasaki, K., Utoh, M., and Yamazaki, H." "Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. " "Drug Metab. Dispos" 42 867-871 2014 "[Original paper]" "Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys." "Uehara, S., Murayama, N., Nakanishi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y." Xenobiotica 44 769-774 2014 "[Original paper]" "Voriconazole metabolism, toxicity and the effect of cytochrome P450 2C19 genotype. " "Zonios, D., Yamazaki, H., Murayama, N., Natrarajan, V., Palmore, T., Childs, R., Skinner, J., and Bennett, J." J.Infect.Dis. 209 1941-1948 2014 "[Original paper]" "Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population." "Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R." "Brit.J. Clin. Pharmacol." 77 839-851 2014 "[Original paper]" "Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor." "Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H." "Chem. Res.Toxicol." 27 304-308 2014 "[Original paper]" "Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans." "264. Nakamaru, Y., Hayashi, Y., Ikegawa, R., Kinoshita, S., Madera, B. P., Gunput, D., Kawaguchi, A., Davies, M., Mair, S., Yamazaki, H., Kume, T., and Suzuki, M." Xenobiotica 44 242-253 2014 "[Original paper]" "Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. " "Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H." Xenobiotica 44 10-16 2014 "[Original paper]" "Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analog of thalidomide." "Chowdhury G, Shibata N, Yamazaki H., and Guengerich FP." "Chem. Res.Toxicol." 27 147-156 2014 "[Original paper]" "The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice." "Higuchi, Y., Kawai, K., Yamazaki, H., Nakamura, M., Bree, F., Guillouzo, C., and Suemizu, H. " Xenobiotica 44 146-153 2014