教員

赤星 軌征准教授 / 博士(医学)last update : 2020.04.01

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研究者名
赤星 軌征(アカホシ ノリユキ)
所属
衛生化学研究室
担当科目
衛生薬学実習 (3年後期)
環境科学(3年後期)
公衆衛生学(4年前期)
職位
准教授
学位
博士(医学)
  • 原著論文 Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4. Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S. J Clin Invest. 130 121955 2019 
  • 原著論文 Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria. Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I. Int J Mol Sci. 20 E3507 2019 
  • 原著論文 Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria. Akahoshi N, Yokoyama A, Nagata T, Miura A, Kamata S, Ishii I. Biol Pharm Bull. 42 1054-1057 2019 
  • 原著論文 Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice. Akahoshi N, Anan Y, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada KI, Kamata S, Ishii I. J Nutr Biochem. 69 120-129 2019 
  • 原著論文 The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity. Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T. JCI Insight 3 97293 2018 
  • 原著論文 Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice. Borowczyk K, Wróblewski J, Suliburska J, Akahoshi N, Ishii I, Jakubowski H. Int J Genomics 2018 7570850 2018 
  • 原著論文 2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice. Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I. FEBS Open Bio. 8 1524-1543 2018 
  • 原著論文 Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure. Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M. Hypertension 71 1210-1217 2018 
  • 原著論文 LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, Ishii S, Akahoshi N, Yanagida K, Sumida H, Araki M, Araki K, Yamamura KI, Murakami-Murofushi K, Ueda H. J Pharmacol Sci. 136 93-96 2018 
  • 原著論文 Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. eLife  5 e10561 2016 
  • 原著論文 Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M Int Immuno 28 283-292 2016 
  • 原著論文 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice. Kamata S, Akahoshi N, Ishii I FEBS Open Bio 5 535-541 2015 
  • 原著論文 Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions. Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M J Mol Med 93 879-889 2015 
  • 原著論文 The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S Sci Rep  5 11410 2015 
  • 原著論文 Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice. Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I Toxicol Appl Pharmacol  282 195-206 2015 
  • 原著論文 Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria. Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I Am J Physiol Renal Physiol  306 F1462-F1476 2014 
  • 原著論文 TDAG8 activation inhibits osteoclastic bone resorption. Hikiji H, Endo D, Horie K, Harayama T, Akahoshi N, Igarashi H, Kihara Y, Yanagida K, Takeda J, Koji T, Shimizu T, Ishii S FASEB J 28 871-879 2014 
  • 原著論文 Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria. Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I Free Radic Biol Med 52 1716-1726 2012 
  • 原著論文 TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates. Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I Anal Bioanal Chem 402 1859-1864 2011 
  • 原著論文 Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria. Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I Anal Bioanal Chem 400 1853-1863 2011 
  • 原著論文 Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2. Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I Epilepsy Behav 22 659-665 2011 
  • 原著論文 Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M J Biol Chem 285 26358-26368 2010 
  • 原著論文 Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia. Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I Hum Mol Genet 17 1994-2005 2008 
  • 原著論文 Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures. Akahoshi N, Murashima YL, Himi T, Ishizaki Y, Ishii I Neurosci Lett 429 136-141 2007 
  • 総説 システイン生合成経路の破綻による病態. 石井功, 赤星軌征 アミノ酸研究 1 37-39 2007 
  • 原著論文 Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation. Akahoshi N, Izumi T, Ishizaki Y, Ishii I Biol Pharm Bull 29 1799-1802 2006 
  • 原著論文 Murine cystathionine γ-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, and Kimura H Biochem J 381 113-123 2004 

研究業績(学会発表等)

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  • ポスター発表 Cystathionine gamma-lyase 欠損母マウスにおける授 乳行動異常 赤星 軌征, 半田 博紀, 横山 輝, 石井 功  日本薬学会第138年会 金沢 2018/3/26
  • ポスター発表 Cystathionine gamma-lyase 欠損マウスにおける妊娠高血圧症候群と育児放棄 赤星 軌征, 半田 博紀, 石井 功  フォーラム2017 衛生薬学・環境トキシコロジー 仙台 2017/9/1
  • 口頭発表 Exacerbation of passive anaphylaxis in LPA5 deficient mice. Akahoshi N, Taketomi Y, Murakami M, Ishii S 日本生化学会大会 仙台 2016/09/25
  • 口頭発表 リゾホスファチジン酸第5受容体 (LPA5) シグナルによるマスト細胞抑制機構 赤星軌征, 武富芳隆, 村上誠, 石井聡 日本脂質生化学会 秋田 2016/06/09
  • ポスター発表 Neutral aminoaciduria in cystathionine beta-synthase-deficient mice, an animal model of homocystinuria. Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I 日本生化学会大会 京都 2014/10/15
  • ポスター発表 TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates. Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I 日本生化学会大会 福岡 2012/12/14
  • 口頭発表 GPCRと炎症性腸疾患 赤星軌征, 石井聡 新学術領域「脂質マシナリー」若手ワークショップ 東京 2012/02/01
  • ポスター発表 Frequent spontaneous seizures followed by enhanced hippocampal gliosis and spatial working memory/anxiety deficits in mice lacking the sphingosine 1-phosphate receptor 2. Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I 日本生化学会大会 京都 2011/09/21
  • ポスター発表 Pregnancy-induced hypertension and proteinuria in hyperhomocysteinemic mice. Akahoshi N, Suematsu M, Ishii I 日本生化学会大会 神戸 2010/12/07
  • ポスター発表 Metabolomic analysis of kidneys in CBS-deficient mice using CE-MS. Akahoshi N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Ishii I 日本生化学会大会 神戸 2009/10/21
  • ポスター発表 Disorders in homocysteine metabolism: Impaired tubular amino acid reabsorption in genetically engineered mouse models for homocystiuria and cystathioninuria.  Akahoshi N, Ishii I 日本分子生物学会・日本生化学会合同年会 神戸 2008/12/09
  • ポスター発表 The CNS abnormality in adult cystathionine β-synthase-deficient mice. Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I 日本神経科学会 東京 2008/09/11
  • ポスター発表 Genechip analysis of the neocortical and hippocampal gene expression in kainate- and nicotine-injected mice.  Akahoshi N, Murashima YL, Himi T, Ishizaki Y, Ishii I 日本神経科学会 横浜 2007/09/10
  • ポスター発表 Cystathionine γ-lyase-deficient mice as animal models for cystathioninemia.  Akahoshi N, Izumi T, Ishizaki Y, Ishii I 日本分子生物学会・日本生化学会合同年会 京都 2006/06/18
  • 口頭発表 マウスてんかん誘導モデルにおける脳内遺伝子発現の変化 赤星軌征, 石井功 日本薬学会年会 東京 2005/03/29
  • 口頭発表 Characterization of cystathionine γ-lyase in mice, a key enzyme in the transsulfuration pathway for the biosynthesis of cysteine.  赤星軌征, 喩小念, 小林友里子, 行方和彦, 木村英雄, 石井功 日本生化学会大会 横浜 2004/10/13
  • ポスター発表 Oogenesis in hydra, analysis by DD-RT-PCR. Akahoshi N, Tada A, Koizumi O, Kobayakawa Y International workshop on hydroid development Tutzing (Germany) 1997/09/22
  • 口頭発表 ヒドラの卵形成に関わる遺伝子の検索. 赤星軌征, 多田在倫, 小泉修, 小早川義尚 日本発生生物学会年会 筑波 1997/05/27

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