Staff
Susumu ItohProfessor / Ph.D.last update : 2023.08.29
Profile
- Name
- Susumu Itoh
- Affiliation
- Laboratory of Biochemistry
- Subjects
- Official title
- Professor
- Degree
- Ph.D.
Academic background
1990 Ph.D. (Pharmaceutical Sciences), Osaka University, Osaka, Japan
1987 M.S. (Pharmaceutical Sciences), Osaka University, Osaka, Japan
1985 B.S. (Pharmaceutical Sciences), Osaka University, Osaka, Japan
1981 Graduated from Nishinomiya-Higashi High School, Nishinomiya, Japan
Career history
2010- Professor, Laboratory of Biochemistry, Showa Pharmaceutical University, Japan
2004-2010 Associate Professor, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
2002-2004 Associate Professor, Institute of Basic Medical Sciences, University of Tsukuba, Japan
1999-2002 Postdoctoral Fellow, The Netherlands Cancer Institute, The Netherlands
1996-1999 Postdoctoral Fellow, Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
1994-1996 Research Associate, Faculty of Pharmaceutical Sciences, Osaka University, Japan
1990-1994 Research Associate, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
Research fields
TGF-β signal
angiogenesis
oncogene and tumor suppressor gene
epithelial mechencymal transition
tumorigenisity
Books
- 薬学のための分子生物学 編集[金田 典雄、伊東 進] 伊東 進、伊東 史子 第7章 遺伝子工学 256-276 廣川書店 2014
- がん増殖と悪性化の分子機構 編集[宮澤 恵二、伊東 進] 伊東 進 2章 増殖抑制シグナルの破綻 27-41 化学同人 2012
- がん増殖と悪性化の分子機構 編集[宮澤 恵二、伊東 進] 宮澤 恵二、伊東 進 序章 がん研究の進歩 1-9 化学同人 2012
- 別冊医学のあゆみ 伊東 進 TGF-βファミリーシグナル抑制機構 13-19 医歯薬出版 2011
- Transforming growth factor-β in cancer therapy (ed. Jakowlew SB) Itoh S., Suzuki H., Itoh F., Miyazono K., Kato M. Negative regulation of the TGF-β family signal pathway by inhibitory Smads and their involvement in cancer and fibrosis. 649-662 Humana Press 2008
Papers
- 原著論文 Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. 110. Nakano N, Sakata N, Katsu Y, Nochise D, Sato E, Takahashi Y, Yamaguchi S, Haga Y, Ikeno S, Motizuki M, Sano K, Yamasaki K, Miyazawa K, Itoh S. J. Biol Chem. 295 9033–9051 [Related links]
- 原著論文 Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein (YAP) degrader. Nakano N, Fukuda K, Tashiro E, Ishikawa H, Nagano W, Kawamoto R, Mori A, Watanabe M, Yamazaki R, Nakane T, Naito M, Okamoto I, Itoh S. J. Biochem. 171 631-640 2022
- 原著論文 Involvement of miR-3180-3p and miR-4632-5p in palmitic acid-induced insulin resistance. Tashiro E, Nagasawa Y, Itoh S, Imoto M. Mol. Cell. Endocrinol. 534 111371 2021
- 原著論文 Endothelial-specific depletion of TGF-β signaling affects lymphatic function. Fukasawa K, Hanada K, Ichikawa K, Hirashima M, Takagi T, Itoh S, Watabe T, Itoh F. Inflamm. Regeneration 41 35 2021
- 原著論文 Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD4 Kawamot R, Nakano N, Ishikawa H, Tashiro E, Nagano W, Sano K, Irie M, Ikuta M, Kishi F, Nakane T, Naito M, Itoh S BBA Advances 1 100008 2021 [Related links]
Conference, etc.
- ポスター発表 Suppression of intestinal tumors in mice lacking TMEPAI which inhibits the TGF-β signaling Teppei Shibasaki, Keigo Sano, Yutaro Sawada, Syoei Amano, Ryo Ishikawa, Fumiko Itoh, Yukihide Watanabe, Makoto M Taketo, Mitsuyasu Kato, Susumu Itoh 12th International BMP Conference Ito Hall, University of Tokyo, Tokyo, Japan 2018/10/24~2018/10/28
- ポスター発表 PDZK1IP1 perturbs TGF-β/ BMP signaling by trapping Smad4 Naoko Nakano, Souichi Ikeno, Keigo Sano, Nobuo Sakata, Fumiko Itoh, Takashi Minowa, Nobutaka Hanagata, Makiko Fujii, Susumu Itoh 12th International BMP Conference Ito Hall, University of Tokyo, Tokyo, Japan 2018/10/24~2018/10/28
- 口頭発表 Role of TMEPAI family in epithelial cell differentiation using genetically modified mouse model: Focusing on oncogenesis Susumu Itoh TGF-β signaling Meeting Leiden Leiden, The Netherlands 2019/8/22~2019/8/24
- ポスター発表 Dissociation of AhR/Arnt Complex by TGF-β/Smad Pathway Results in Suppression of CYP1A1 Gene: Inhibition of Benze[a]pyrene-mediated Cytotoxicity by TGF-β Susumu Itoh, Naoko Nakano, Keigo Sano, Souichi Ikeno, Nobuo Sakata FASEB SRC: The TGF-β Superfamily Conference: Signaling in Development and Disease West Palm Beach, Florida, USA 2019/7/28~2019/8/2
- 特別講演・シンポジウム BMP signaling maintains lymphatic function Fumiko Itoh, Toshihiko Inagawa, Miho Ishibashi, Yuki Saito, Yoshiaki Kubota, Susumu Itoh 第40回日本分子生物学会年会 パシフィッコ横浜、横浜、神奈川 2018/11/28~2018/11/30