Staff

Yutaka Masuda  /  last update : 2023.05.16

Japanese

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Name
Yutaka Masuda
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Degree
 
  • 衛生薬学 今井浩孝・小椋康光 編集 環境保全と法的規制 527-541 南江堂 2016 978-4-524-40317-2C3047
  • [Original paper] Effects of IgM anti-galnac-GD1a monoclonal antibodies on neuromuscular transmission and calcium channel binding in the rat neuromuscular junctions. Hotta S, Nagaoka T, Nakatani Y, Kambe T, Abe K, Masuda Y, Utsumomiya I, Taguchi K J Neurol Neurophysiol 6 275 2015 
  • [Original paper] Effects of IgG anti-GM1 monoclonal antibodies on neuromuscular transmission and calcium channel binding in the rat neuromuscular junctions. Hotta S, Nakatani Y, Kambe T, Abe K, Masuda Y, Utsumomiya I, Taguchi K Exp Ther Med 10 535-540 2015 
  • [Original paper] Hinesol, a compound isolated from essential oils of Atractylodes lancea rhizome, inhibits the cell growth and induces apoptosis in human leukemia HL-60 cells. Masuda Y, Kadokura T, Ishii M, Takada K, Kitajima J J Nat Med  69 332-339 2015 
  • [Original paper] Capillin, a major constituent of Artemisia capillaris Thunb. flower essential oil, induces apoptosis through the mitochondrial pathway in human leukemia HL-60 cells. Masuda Y, Asada K, Satoh R, Takada K, Kitajima J Phytomedicine 22 545-552 2015 
  • [Original paper] PI3-kinase inhibitor LY294002 repress expression of thrombin-activatable fibrinolysis inhibitor in human hepatoma HepG2 cells. Masuda Y, Yazawa J, Makino Y, Takada K Biol Phram Bull 38 1529-1535 2015 
  • [Original paper] Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission: effects in rat neuromuscular junctions. Hotta S, Nagaoka T, Taguchi K, Nakatani Y, Utsnomiya I, Masuda Y, Abe K, Yuki N Neurol sci  35 205-213 2014 
  • [Original paper] Nobiletin, a polymethoxyflavone in citrus fruits, reduces TAFI expression in HepG2 cells through transcriptional inhibition. Takada K, Seike T, Sasaki T, Masuda Y, Ito A, Ishii H Thromb Haemost 109 1060-1069 2013 
  • [Original paper] Peroxisome proliferator-activated receptor-alpha agonists repress expression of thrombin-activatable fibrinolysis inhibitor by decreasing transcript stability. Masuda Y, Saotome D, Takada K, Sugimoto K, Sasaki T, Ishii H Thromb Haemost  108 74-85 2012 
  • [Review] The role of mitochondrial chaperone tumor necrosis factor-associated protein 1 (TRAP1) in the regulation of apoptosis. Masuda Y Journal of Health Science 57 1-9 2011 
  • [Review] Vitamin K2 as a chemotherapeutic agent for treating ovarian cancer. Nakaya, K., Masuda, Y., Aiuchi T., and Itabe H. Ovarian Cancer/Book   259-274 2011 
  • [Original paper] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver. Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H J Lipid Res  51 2571-2580 2010 
  • [Review] TRAP1: a regulator of mitochondrial functions and apoptosis. Masuda Y. and Itabe H Mitochondria: Structure, Functions and Dysfunctions  927-940 2009 
  • [Original paper] Expression of thrombin-activatable fibrinolysis inhibitor (TAFI) is up-regulated by increase in intracellular cyclic AMP levels in cultured HepG2 cells. Ishii H, Kojima Y, Masuda Y, Takada K, Sugimoto K, Ikeda T Thromb Haemost  102 1204-1211 2009 
  • [Original paper] Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation. Hirata Y, Masuda Y, Kakutani H, Higuchi T, Takada K, Ito A, Nakagawa Y, Ishii H Biochem Pharmacol 75 1504-1514 2008 
  • [Original paper] A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity. Kajimoto S, Horie M, Manabe H, Masuda Y, Shibayama-Imazu T, Nakajo S, Gong XF, Obama T, Itabe H, Nakaya K Biochim Biophys Acta 1782 41-50 2008 
  • [Original paper] A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA Immunity 28 64-74 2008 
  • [Original paper] Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K(2) is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei. Sibayama-Imazu T, Fujisawa Y, Masuda Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K J Cancer Res Clin Oncol  134 803-812 2008 
  • [Original paper] Involvement of Tiam1 in apoptosis induced by bufalin in HeLa cells. Cao H, Shibayama-Imazu T, Masuda Y, Shinki T, Nakajo S, Nakaya K Anticancer Res 27 245-249 2007 
  • [Original paper] Increase in intracellular Ca(2+) concentrations and the corresponding intracellular acidification are early steps for induction of apoptosis by geranylgeraniol in HL60 cells. Masuda Y, Aiuchi T, Mihara S, Nakajo S, Nakaya K Biol Pharm Bull  30 880-884 2007 
  • [Original paper] Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS. Obama T, Kato R, Masuda Y, Takahashi K, Aiuchi T, Itabe H Proteomics 7 2132-2141 2007 
  • [Original paper] ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. Masuda Y, Itabe H, Odaki M, Hama K, Fujimoto Y, Mori M, Sasabe N, Aoki J, Arai H, Takano T J Lipid Res 47 87-98 2006 
  • [Original paper] A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol. Masuda Y, Maeda S, Watanabe A, Sano Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K Biochem Biophys Res Commun 346 454-460 2006 
  • [Original paper] The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells. Komuro A*, Masuda Y*, Kobayashi K, Babbitt R, Gunel M, Flavell RA, Marchesi VT Proc Natl Acad Sci U S A 101 4053-4058 2004 
  • [Original paper] Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.  Masuda Y, Shima G, Aiuchi T, Horie M, Hori K, Nakajo S, Kajimoto S, Shibayama-Imazu T, Nakaya K J Biol Chem 279 42503-42515 2004 
  • [Original paper] Recombinant curculin heterodimer exhibits taste-modifying and sweet-tasting activities. Suzuki M, Kurimoto E, Nirasawa S, Masuda Y, Hori K, Kurihara Y, Shimba N, Kawai M, Suzuki E, Kato K FEBS Lett 573 135-138 2004 
  • [Original paper] Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1). Masuda Y, Nishida A, Hori K, Hirabayashi T, Kajimoto S, Nakajo S, Kondo T, Asaka M, Nakaya K Oncogene 22 1012-1023 2003 
  • [Original paper] Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols. Choi JH, Ha J, Park JH, Lee JY, Lee YS, Park HJ, Choi JW, Masuda Y, Nakaya K, Lee KT Jpn J Cancer Res 93 1327-1333 2002 
  • [Original paper] Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Hashimoto S, Xu Y, Masuda Y, Aiuchi T, Nakajo S, Uehara Y, Shibuya M, Yamori T, Nakaya K Jpn J Cancer Res 93 944-951 2002 
  • [Original paper] Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores. Kajimoto S, Takanashi N, Kajimoto T, Xu M, Cao J, Masuda Y, Aiuchi T, Nakajo S, Ida Y, Nakaya K Int J Cancer 99 879-890 2002 
  • [Original paper] The mechanism of geranylgeraniol-induced apoptosis involves activation, by a caspase-3-like protease, of a c-Jun N-terminal kinase signaling cascade and differs from mechanisms of apoptosis induced by conventional chemotherapeutic drugs. Masuda Y, Nakaya M, Aiuchi T, Hashimoto S, Nakajo S, Nakaya K Leuk Res 24 937-950 2000 
  • [Original paper] beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide. Hashimoto S, Xu M, Masuda Y, Aiuchi T, Nakajo S, Cao J, Miyakoshi M, Ida Y, Nakaya K J Biochem (Tokyo) 125 17-23 1999 
  • [Original paper] Induction of apoptosis by bufalin in human tumor cells is associated with a change of intracellular concentration of Na+ ions. Kawazoe N, Aiuchi T, Masuda Y, Nakajo S, Nakaya K J Biochem (Tokyo)  126 278-286 1999 
  • [Original paper] Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Kawazoe N, Watabe M, Masuda Y, Nakajo S, Nakaya K Oncogene 18 2413-2421 1999 
  • [Original paper] Analysis of caspases that are activated during apoptosis in leukemia U937 cells in response to geranylgeraniol. Nakaya M, Masuda Y, Mihara S, Aiuchi T, Shibayama-Imazu T, Nakajo S, Nakaya K Anticancer Res 19 5063-5068 1999 
  • [Original paper] Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells. Aiuchi T, Mihara S, Nakaya M, Masuda Y, Nakajo S, Nakaya K J Biochem (Tokyo) 124 300-303 1998 
  • [Original paper] Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. Watabe M, Ito K, Masuda Y, Nakajo S, Nakaya K Oncogene 16 779-787 1998 
  • [Original paper] Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs. Hashimoto S, Jing Y, Kawazoe N, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K Leuk Res 21 875-883 1997 
  • [Original paper] Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells. Masuda Y, Nakaya M, Nakajo S, Nakaya K Biochem Biophys Res Commun 234 641-645 1997 
  • [Original paper] Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells. Masuda Y, Yoda M, Ohizumi H, Aiuchi T, Watabe M, Nakajo S, Nakaya K Int J Cancer  71 691-697 1997 
  • [Original paper] Induction of apoptosis in various tumor cell lines by geranylgeraniol. Ohizumi H, Masuda Y, Yoda M, Hashimoto S, Aiuchi T, Nakajo S, Sakai I, Ohsawa S, Nakaya K Anticancer Res 17 1051-1057 1997 
  • [Original paper] Galactose-inducible expression systems in Candida maltosa using promoters of newly-isolated GAL1 and GAL10 genes. Park SM, Ohkuma M, Masuda Y, Ohta A, Takagi M Yeast 13 21-29 1997 
  • [Original paper] Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells. Watabe M, Kawazoe N, Masuda Y, Nakajo S, Nakaya K Cancer Res  57 3097-3100 1997 
  • [Original paper] Complete nucleotide sequences of the genes encoding translation elongation factors 1 alpha and 2 from a microsporidian parasite, Glugea plecoglossi: implications for the deepest branching of eukaryotes. Kamaishi T, Hashimoto T, Nakamura Y, Masuda Y, Nakamura F, Okamoto K, Shimizu M, Hasegawa M J Biochem (Tokyo)  120 1095-1103 1996 
  • [Original paper] Geranylgeraniol causes a decrease in levels of calreticulin and tyrosine phosphorylation of a 36-kDa protein prior to the appearance of apoptotic features in HL-60 cells. Nakajo S, Okamoto M, Masuda Y, Sakai I, Ohsawa S, Nakaya K Biochem Biophys Res Commun 226 741-745 1996 
  • [Original paper] Cloning and sequencing of a cDNA encoding a heat-stable sweet protein, mabinlin II. Nirasawa S, Masuda Y, Nakaya K, Kurihara Y Gene 181 225-227 1996 
  • [Original paper] Purification and characterization of bleomycin hydrolase, which represents a new family of cysteine proteases, from rat skin. Takeda A, Higuchi D, Yamamoto T, Nakamura Y, Masuda Y, Hirabayashi T, Nakaya K J Biochem (Tokyo)  119 29-36 1996 
  • [Original paper] Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease. Takeda A, Masuda Y, Yamamoto T, Hirabayashi T, Nakamura Y, Nakaya K J Biochem (Tokyo) 120 353-359 1996 
  • [Original paper] The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. Watabe M, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K J Biol Chem 271 14067-14072 1996 
  • [Original paper] Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells. Masuda Y, Kawazoe N, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K Leuk Res 19 549-556 1995 
  • [Original paper] Cloning and sequencing of a cDNA encoding a taste-modifying protein, miraculin. Masuda Y, Nirasawa S, Nakaya K, Kurihara Y Gene  161 175-177 1995 
  • [Original paper] Cloning and characterization of the POX2 gene in Candida maltosa.  Masuda Y, Park SM, Ohta A, Takagi M Gene 167 157-161 1995 
  • [Original paper] Geranylgeraniol is a potent inducer of apoptosis in tumor cells. Ohizumi H, Masuda Y, Nakajo S, Sakai I, Ohsawa S, Nakaya K J Biochem (Tokyo) 117 11-13 1995 
  • [Original paper] Evidence that the expression of the gene for NADPH-cytochrome P-450 reductase is n-alkane-inducible in Candida maltosa. Ohkuma M, Masuda Y, Park SM, Ohtomo R, Ohta A, Takagi M Biosci Biotechnol Biochem 59 1328-1330 1995 
  • [Original paper] In vivo evidence for non-universal usage of the codon CUG in Candida maltosa. Sugiyama H, Ohkuma M, Masuda Y, Park SM, Ohta A, Takagi M Yeast 11 43-52 1995 
  • [Original paper] Selective inhibitory effect of bufalin on growth of human tumor cells in vitro: association with the induction of apoptosis in leukemia HL-60 cells. Jing Y, Ohizumi H, Kawazoe N, Hashimoto S, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K Jpn J Cancer Res 85 645-651 1994 
  • [Original paper] Expression of an endogenous and a heterologous gene in Candida maltosa by using a promoter of a newly-isolated phosphoglycerate kinase (PGK) gene. Masuda Y, Park SM, Ohkuma M, Ohta A, Takagi M Curr Genet 25 412-417 1994 
  • [Original paper] Evolutionary position of n-alkane-assimilating yeast Candida maltosa shown by nucleotide sequence of small-subunit ribosomal RNA gene. Ohkuma M, Hwang CW, Masuda Y, Nishida H, Sugiyama J, Ohta A, Takagi M Biosci Biotechnol Biochem 57 1793-1794 1993 
  • [Original paper] Determination of the phosphorylation sites of calmodulin catalyzed by casein kinase 2 Nakajo S, Masuda Y, Nakaya K, Nakamura Y J Biochem (Tokyo) 104 946-951 1988 

Conference, etc.

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  • [Poster presentation] 実務実習事前学習における学習者の態度評価の客観性と自己評価の検討 ○福井楓、土肥弘久、萩原幸彦、堀口よし江、増田豊、北島潤一、高野昭人、千葉良子、濱島肇、濵本知之、廣原正宜、福森隆次、小野寺敏、渡部一宏、山本健、山本美智子 日本薬学会第136年会 横浜 2016/03/26〜2016/03/29
  • [Oral presentation] 新規 TAFIa 阻害剤 7-Amino-2-(sulfanylmethyl) heptanoic acid の線溶促進作用 ○ 高田公彦、佐々木知幸、杉本勝良、清家 亨、増田 豊、村山典恵、山崎浩史、吉本暢子、山本恵子、石井秀美 第13回 Pharmaco-Hematology シンポジウム 東京 2012/06/15〜2012/06/16
  • [Poster presentation] AP-1 は TAFI 発現に関わる調節因子であり、ノビレチンによる TAFI 発現抑制機序に関わる ○高田公彦、佐々木知幸、清家 亨、増田 豊、石井秀美 第34回日本血栓止血学会学術集会 東京 2012/06/07〜2012/06/09

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