プロフィール

研究者名

清水 万紀子（シミズ マキコ）

所属

薬物動態学研究室

担当科目

薬物動態学Ⅰ（3年前期）
薬物動態学Ⅱ（3年後期）
個別化治療の基礎（4年前期）

職位

准教授

学位

博士（薬学）

研究業績（著書）

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• 月刊薬事2016年1月臨時増刊号「臨床の疑問に答える がん薬物療法アップデート」　清水万紀子、山崎浩史　抗がん薬と薬物代謝酵素　398-407　じほう　2016　
• 先天代謝異常ハンドブック　山崎浩史、清水万紀子　トリメチルアミン尿症　120-121　中山書店　2013　

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研究業績（論文）

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• 原著論文　Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs　Shimizu, M.; Nii, A.; Uno, Y.; Yamazaki, H.　Drug Metab Dispos　53　100140　2025　
• 原著論文　Virtual hepatic and plasma exposure of voriconazole administered to cytochrome P450 2C19 poor metabolizers as possible causal factor for hepatic disorder in Japanese database predicted by simplified and full pharmacokinetic modeling systems　Adachi, K.; Ohyama, K.; Shimura, Y.; Tanaka, Y.; Shimizu, M.; Saito, Y.; Yamazaki, H.　Biol Pharm Bull　48　1271-1276　2025　
• 原著論文　In silico estimation for binary classification of unaffected and impaired catalytic function of flavin-containing monooxygenase 3 (FMO3) variants and in vitro validation in an updating of Japanese genome resource database　Shimizu, M.; Hishinuma, E.; Igarashi, R.; Saito, S.; Makiguchi, M.; Hiratsuka, M.; Yamazaki, H.　Biol Pharm Bull　48　1062-1069　2025　
• 原著論文　Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies　Tanaka, Y.; Shimizu, M.; Saito, Y.; Yamazaki, H.　Drug Metab Pharmacokinet　62　101496　2025　
• 原著論文　Reported liver toxicity of food chemicals in rats extrapolated to humans using virtual human-to-rat hepatic concentration ratios generated by pharmacokinetic modeling with machine learning-derived parameters　Adachi, K.; Hosoi, M.; Shimura, Y.; Shimizu, M.; Yamazaki, H.　J Toxicol Sci　50　205-213　2025　
• 原著論文　Impact of variability of in silico and in vitro octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations　Adachi, K.; Sasaki, T.; Arai, A.; Shimizu, M.; Yamazaki, H.　J Toxicol Sci　49　459-466　2024　
• 原著論文　Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman　Adachi, K.; Murata, M.; Inada, A.; Morimoto, T.; Shimizu, M.; Beppu, S.; Yamazaki, H.　Acute Med Surg　11　e985　2024　
• 原著論文　Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs　Shimizu, M.; Makiguchi, M.; Uno, Y.; Yamazaki, H.　Drug Metab Dispos　52　906-910　2024　
• 原著論文　Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database　Adachi, K.; Ohyama, K.; Tanaka, Y.; Murayama, N.; Shimizu, M.; Saito, Y.; Yamazaki, H.　Biol Pharm Bull　47　1028-1032　2024　
• 原著論文　In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells　Uehara, S.; Murayama, N.; Higuchi, Y.; Shimizu, M.; Suemizu, H.; Guengerich, F. P.; Yamazaki, H.　Chem Res Toxicol　37　671-674　2024　
• 原著論文　Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances　Adachi, K.; Shimizu, M.; Shono, F.; Funatsu, K.; Yamazaki, H.　J Toxicol Sci　49　127-137　2024　
• 原著論文　Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database　Adachi, K.; Ohyama, K.; Tanaka, Y.; Saito, Y.; Shimizu, M.; Yamazaki, H.　Biol Pharm Bull　47　635-640　2024　
• 原著論文　Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources　Shimizu, M.; Makiguchi, M.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H.　Drug Metab Pharmacokinet　55　100539　2024　
• 原著論文　Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews　Uno, Y.; Makiguchi, M.; Ushirozako, G.; Tsukiyama-Kohara, K.; Shimizu, M.; Yamazaki, H.　Comp Biochem Physiol C Toxicol Pharmacol　277　109835　2024　
• 原著論文　Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6　Shimizu, M.; Uehara, S.; Ohyama, K.; Nishimura, H.; Tanaka, Y.; Saito, Y.; Suemizu, H.; Yoshida, S.; Yamazaki, H.　Drug Metab Dispos　52　35-43　2024　
• 原著論文　Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection　Negishi, D.; Mitsumatsu, O.; Mitsumatsu, H.; Makiguchi, M.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　9　33　2023　
• 原著論文　Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank　Shimizu, M.; Makiguchi, M.; Yokota, Y.; Shimamura, E.; Matsuta, M.; Nakamura, Y.; Harano, M.; Yamazaki, H.　Drug Metab Pharmacokinet　53　100528　2023　
• 原著論文　A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis - A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir　Unita, R.; Adachi, K.; Inada, A.; Shimizu, M.; Beppu, S.; Yamazaki, H.　J Infect Chemother　29　1068-1070　2023　
• 原著論文　Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in Silico Liver-to-Plasma Partition Coefficients　Adachi, K.; Utsumi, M.; Sato, T.; Nakano, H.; Shimizu, M.; Yamazaki, H.　Biol Pharm Bull　46　1316-1323　2023　
• 原著論文　Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in Silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats　Adachi, K.; Nakano, H.; Sato, T.; Shimizu, M.; Yamazaki, H.　Biol Pharm Bull　46　1133-1140　2023　
• 原著論文　Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database　Adachi, K.; Ohyama, K.; Tanaka, Y.; Nakano, H.; Sato, T.; Murayama, N.; Shimizu, M.; Saito, Y.; Yamazaki, H.　Biol Pharm Bull　46　856-863　2023　
• 原著論文　Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources　Makiguchi, M.; Shimizu, M.; Yokota, Y.; Shimamura, E.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H.　Drug Metab Dispos　51　884-891　2023　
• 原著論文　Roles of human cytochrome P450 3A4/5 in dexamethasone 6beta-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin　Uehara, S.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　Drug Metab Pharmacokinet　50　100504　2023　
• 原著論文　A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria　Shimizu, M.; Yamamoto, A.; Makiguchi, M.; Shimamura, E.; Yokota, Y.; Harano, M.; Yamazaki, H.　Drug Metab Pharmacokinet　50　100490　2023　
• 原著論文　High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4 *16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database　Adachi, K.; Ohyama, K.; Tanaka, Y.; Sato, T.; Murayama, N.; Shimizu, M.; Saito, Y.; Yamazaki, H.　Drug Metab Pharmacokinet　49　100486　2023　
• 原著論文　Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models　Miura, T.; Uehara, S.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　J Toxicol Sci　47　531-538　2022　
• 原著論文　Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans　Adachi, K.; Shimizu, M.; Yamazaki, H.　Biol Pharm Bull　45　1812-1817　2022　
• 原著論文　Updated in silico prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for estimating internal concentrations in rats　Adachi, K.; Shimizu, M.; Yamazaki, H.　J Toxicol Sci　J Toxicol Sci　453-456　2022　
• 原著論文　Correction to An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats""　Kamiya, Y.; Handa, K.; Miura, T.; Ohori, J.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H.　Chem Res Toxicol　35　1433　2022　
• 原著論文　Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria　Shimizu, M.; Hirose, N.; Kato, M.; Sango, H.; Uenuma, Y.; Makiguchi, M.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H.　Drug Metab Pharmacokinet　46　100465　2022　
• 原著論文　Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus　Negishi, D.; Mitsumatsu, O.; Matsumura, T.; Mitsumatsu, H.; Makiguchi, M.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　8　16　2022　
• 原著論文　Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats　Uno, Y.; Shimizu, M.; Ogawa, Y.; Makiguchi, M.; Kawaguchi, H.; Yamato, O.; Ishizuka, M.; Yamazaki, H.　Biochem Pharmacol　202　115125　2022　
• 原著論文　Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals　Shimizu, M.; Hayasaka, R.; Kamiya, Y.; Yamazaki, H.　Biol Pharm Bull　45　1142-1157　2022　
• 原著論文　Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo　Uehara, S.; Shimizu, M.; Ple, K.; Routier, S.; Yoneda, N.; Higuchi, Y.; Suemizu, H.; Yamazaki, H.　Drug Metab Pharmacokinet　44　100453　2022　
• 原著論文　Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model　Kamiya, Y.; Miura, T.; Kato, A.; Murayama, N.; Shimizu, M.; Yamazaki, H.　Drug Metab Bioanal Lett　15　64-69　2022　
• 原著論文　Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals　Kamiya, Y.; Handa, K.; Miura, T.; Ohori, J.; Kato, A.; Shimizu, M.; Kitajima, M.; Yamazaki, H.　Biol Pharm Bull　45　124-128　2022　
• 原著論文　Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5'-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species　Kuwagata, M.; Hasegawa, T.; Takashima, H.; Shimizu, M.; Kitajima, S.; Yamazaki, H.　J Toxicol Sci　46　553-560　2021　
• 原著論文　Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice　Miura, T.; Uehara, S.; Shimizu, M.; Murayama, N.; Suemizu, H.; Yamazaki, H.　J Toxicol Sci　46　525-530　2021　
• 原著論文　An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats　Kamiya, Y.; Handa, K.; Miura, T.; Ohori, J.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H.　Chem Res Toxicol　34　2180-2183　2021　
• 原著論文　A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects　Shimizu, M.; Mizugaki, A.; Koibuchi, N.; Sango, H.; Uenuma, Y.; Yamazaki, H.　Drug Metab Pharmacokinet　41　100420　2021　
• 原著論文　Differences in Pharmacokinetics and Haematotoxicities of Aniline and Its Dimethyl Derivatives Orally Administered in Rats　Miura, T.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Yamazaki, H.　Biol Pharm Bull　44　1775-1780　2021　
• 原著論文　Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital　Adachi, K.; Beppu, S.; Terashima, M.; Fukuda, T.; Tomizawa, J.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　7　36　2021　
• 原著論文　Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital　Adachi, K.; Sugitani, Y.; Unita, R.; Yoshida, K.; Beppu, S.; Terashima, M.; Fujii, M.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　7　33　2021　
• 原著論文　Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model　Yanagi, M.; Kamiya, Y.; Murayama, N.; Banju, K.; Shimizu, M.; Yamazaki, H.　J Toxicol Sci　46　391-399　2021　
• 原著論文　Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes　Taniguchi-Takizawa, T.; Kato, N.; Shimizu, M.; Kume, T.; Yamazaki, H.　Drug Metab Pharmacokinet　40　100412　2021　
• 原著論文　Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital　Adachi, K.; Beppu, S.; Terashima, M.; Kobari, W.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　7　32　2021　
• 原著論文　Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments　Yamazaki, H.; Shimizu, M.; Otani, T.; Mizugaki, A.; Mure, K.; Suzuki, S.; Ishikawa, H.　J Pharm Health Care Sci　7　26　2021　
• 原著論文　Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes　Miura, T.; Uehara, S.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　J Toxicol Sci　46　311-317　2021　
• 原著論文　Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1　Uehara, S.; Uno, Y.; Shimizu, M.; Yamazaki, H.　Drug Metab Pharmacokinet　39　100398　2021　
• 原著論文　Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam　Emoto, C.; Shimizu, M.; Tanaka, T.; Yamazaki, H.　Drug Metab Pharmacokinet　39　100394　2021　
• 原著論文　Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models　Miura, T.; Kamiya, Y.; Uehara, S.; Murayama, N.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　Xenobiotica　51　636-642　2021　
• 原著論文　Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources　Shimizu, M.; Koibuchi, N.; Mizugaki, A.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H.　Drug Metab Pharmacokinet　38　100387　2021　
• 原著論文　Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants　Taniguchi-Takizawa, T.; Kato, H.; Shimizu, M.; Yamazaki, H.　Curr Drug Metab　22　208-214　2021　
• 原著論文　Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling　Toda, A.; Shimizu, M.; Uehara, S.; Sasaki, T.; Miura, T.; Mogi, M.; Utoh, M.; Suemizu, H.; Yamazaki, H.　Xenobiotica　51　316-323　2021　
• 原著論文　Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model　Miura, T.; Uehara, S.; Shigeta, K.; Yoshizawa, M.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　Chem Res Toxicol　34　522-528　2021　
• 原著論文　In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals　Kamiya, Y.; Handa, K.; Miura, T.; Yanagi, M.; Shigeta, K.; Hina, S.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H.　Chem Res Toxicol　34　507-513　2021　
• 原著論文　Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital　Adachi, K.; Beppu, S.; Nishiyama, K.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　7　6　2021　
• 原著論文　In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice　Shimizu, M.; Uehara, S.; Suemizu, H.; Yamazaki, H.　Drug Metab Pharmacokinet　37　100369　2021　
• 原著論文　Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan　Uraoka, M.; Shimizu, M.; Kuwajima, Y.; Mizugaki, A.; Yokoyama, H.; Mure, K.; Yamazaki, H.　Curr Drug Metab　21　1161-1164　2020　
• 原著論文　Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential　Miura, T.; Shimizu, M.; Uehara, S.; Yoshizawa, M.; Nakano, A.; Yanagi, M.; Kamiya, Y.; Murayama, N.; Suemizu, H.; Yamazaki, H.　Chem Res Toxicol　33　3048-3053　2020　
• 原著論文　Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)　Shimizu, M.; Uno, Y.; Utoh, M.; Yamazaki, H.　Drug Metab Pharmacokinet　35　571-573　2020　
• 原著論文　Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model　Miura, T.; Kamiya, Y.; Hina, S.; Kobayashi, Y.; Murayama, N.; Shimizu, M.; Yamazaki, H.　J Toxicol Sci　45　695-700　2020　
• 原著論文　Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital　Adachi, K.; Tuchiya, J.; Beppu, S.; Nishiyama, K.; Shimizu, M.; Yamazaki, H.　J Pharm Health Care Sci　6　20　2020　
• 原著論文　Expression of functional sulfotransferases (SULT) 1A1, 1A3, 1B1, 1C2, 1E1, and 2A1 in common marmosets　Uno, Y.; Uehara, S.; Murayama, N.; Shimizu, M.; Yamazaki, H.　Biochem Pharmacol　180　114189　2020　
• 原著論文　Correction to Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers""　Uehara, S.; Uno, Y.; Inoue, T.; Kawano, M.; Shimizu, M.; Toda, A.; M., U.; Sasaki, E.; Yamazaki, H.　Drug Metab Dispos　48　723　2020　
• 原著論文　Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations　Ogawa, S. I.; Shimizu, M.; Yamazaki, H.　Xenobiotica　50　1413-1422　2020　
• 原著論文　Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats　Kamiya, Y.; Otsuka, S.; Miura, T.; Yoshizawa, M.; Nakano, A.; Iwasaki, M.; Kobayashi, Y.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H.　Chem Res Toxicol　33　1736-1751　2020　
• 原著論文　Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation　Dionisio, L.; Shimizu, M.; Stupniki, S.; Oyama, S.; Aztiria, E.; Alda, M.; Yamazaki, H.; Spitzmaul, G.　Drug Metab Pharmacokinet　35　383-388　2020　
• 原著論文　Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1　Ogawa, S. I.; Shimizu, M.; Kamiya, Y.; Uehara, S.; Suemizu, H.; Yamazaki, H.　Drug Metab Pharmacokinet　35　354-360　2020　
• 原著論文　Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity　Kamiya, Y.; Takaku, H.; Yamada, R.; Akase, C.; Abe, Y.; Sekiguchi, Y.; Murayama, N.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H.　Toxicol Rep　7　149-154　2020　
• 原著論文　Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment　Ogawa, S. I.; Shimizu, M.; Yamazaki, H.　Xenobiotica　50　1023-1031　2020　
• 原著論文　Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice　Miura, T.; Uehara, S.; Shimizu, M.; Murayama, N.; Utoh, M.; Suemizu, H.; Yamazaki, H.　Chem Res Toxicol　33　634-639　2020　
• 原著論文　Simple pharmacokinetic models accounting for drug monitoring results of atomoxetine and its 4-hydroxylated metabolites in Japanese pediatric patients genotyped for cytochrome P450 2D6　Notsu, Y.; Shimizu, M.; Sasaki, T.; Nakano, A.; Ota, M.; Yoshida, S.; Yamazaki, H.　Drug Metab Pharmacokinet　35　191-200　2020　
• 原著論文　Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling　Ota, M.; Shimizu, M.; Kamiya, Y.; Emoto, C.; Fukuda, T.; Yamazaki, H.　Biopharm Drug Dispos　40　350-357　2019　
• 原著論文　Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database　Shimizu, M.; Yoda, H.; Nakakuki, K.; Saso, A.; Saito, I.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H.　Drug Metab Pharmacokinet　34　334-339　2019　
• 原著論文　Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data　Miura, T.; Uehara, S.; Nakazato, M.; Kusama, T.; Toda, A.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　J Toxicol Sci　44　543-548　2019　
• 原著論文　Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate　Miura, T.; Uehara, S.; Mizuno, S.; Yoshizawa, M.; Murayama, N.; Kamiya, Y.; Shimizu, M.; Suemizu, H.; Yamazaki, H.　Chem Res Toxicol　32　333-340　2019　
• 原著論文　Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria　Shimizu, M.; Yoda, H.; Igarashi, N.; Makino, M.; Tokuyama, E.; Yamazaki, H.　Xenobiotica　49　1244-1250　2019　
• 原著論文　Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital　Yamazaki-Nishioka, M.; Kogiku, M.; Noda, M.; Endo, S.; Takekawa, M.; Kishi, H.; Ota, M.; Notsu, Y.; Shimizu, M.; Yamazaki, H.　Xenobiotica　49　1001-1006　2019　
• 原著論文　Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate　Miura, T.; Suemizu, H.; Goto, M.; Sakai, N.; Iwata, H.; Shimizu, M.; Yamazaki, H.　Xenobiotica　49　513-520　2019　
• 原著論文　Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques　Uno, Y.; Shimizu, M.; Yoda, H.; Origuchi, Y.; Yamazaki, H.　Drug Metab Pharmacokinet　34　104-107　2019　
• 原著論文　Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney　Uno, Y.; Shimizu, M.; Yoda, H.; Yamazaki, H.　J Med Primatol　48　51-53　2019　
• 原著論文　In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants　Nakanishi, K.; Uehara, S.; Kusama, T.; Inoue, T.; Shimura, K.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Uno, Y.; Sasaki, E.; Yamazaki, H.　Biochem Pharmacol　152　272-278　2018　
• 原著論文　Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice　Shimizu, M.; Suemizu, H.; Mizuno, S.; Kusama, T.; Miura, T.; Uehara, S.; Yamazaki, H.　J Toxicol Sci　43　387-393　2018　
• 原著論文　Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine　Wang, L.; Bernert, J. T.; Benowitz, N. L.; Feng, J.; Jacob, P., 3rd; McGahee, E.; Caudill, S. P.; Scherer, G.; Scherer, M.; Pluym, N.; Doig, M. V.; Newland, K.; Murphy, S. E.; Caron, N. J.; Sander, L. C.; Shimizu, M.; Yamazaki, H.; Kim, S.; Langman, L. J.; Pritchett, J. S.; Sniegoski, L. T.; Li, Y.; Blount, B. C.; Pirkle, J. L.　Cancer Epidemiol Biomarkers Prev　27　1083-1090　2018　
• 原著論文　Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA　Murayama, N.; Suemizu, H.; Uehara, S.; Kusama, T.; Mitsui, M.; Kamiya, Y.; Shimizu, M.; Guengerich, F. P.; Yamazaki, H.　J Toxicol Sci　43　369-375　2018　
• 原著論文　Dihydrocodeine Overdoses in a Neonate and in a 14-year-old Girl Who Were Both Genotyped as Cytochrome P450 2D6*1/*10-*36: Comparing Developmental Ages and Drug Monitoring Data With the Results of Pharmacokinetic Modeling　Shimizu, M.; Kondo, T.; Fukuoka, T.; Tanaka, T.; Yamazaki, H.　Ther Drug Monit　40　162-165　2018　
• 原著論文　Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models　Kusama, T.; Toda, A.; Shimizu, M.; Uehara, S.; Inoue, T.; Uno, Y.; Utoh, M.; Sasaki, E.; Yamazaki, H.　Xenobiotica　48　1072-1077　2018　
• 原著論文　Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19　Toda, A.; Uehara, S.; Inoue, T.; Utoh, M.; Kusama, T.; Shimizu, M.; Uno, Y.; Mogi, M.; Sasaki, E.; Yamazaki, H.　Xenobiotica　48　720-726　2018　
• 原著論文　R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys　Utoh, M.; Kusama, T.; Miura, T.; Mitsui, M.; Kawano, M.; Hirano, T.; Shimizu, M.; Uno, Y.; Yamazaki, H.　Xenobiotica　48　206-210　2018　
• 原著論文　Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice　Yamazaki-Nishioka, M.; Shimizu, M.; Suemizu, H.; Nishiwaki, M.; Mitsui, M.; Yamazaki, H.　Xenobiotica　48　117-123　2018　
• 原著論文　Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models　Utoh, M.; Miura, T.; Kusama, T.; Uehara, S.; Shimizu, M.; Uno, Y.; Yamazaki, H.　Biopharm Drug Dispos　38　439-442　2017　
• 原著論文　Effects of Meat Intake Frequency and Polymorphic Cytochrome P450 2A6 Activity on Individual Colorectal Tumour Risk in a Japanese Cohort　Yamazaki, H.; Fujieda, M.; Shimizu, M.; Shiotani, A.; Shimabukuro, M.; Mure, K.; Takeshita, T.; Ishikawa, H.　Journal of Cancer Therapy　8　645-652　2017　
• 原著論文　Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model　Shimizu, M.; Yamazaki, H.　J Toxicol Sci　42　485-490　2017　
• 原著論文　Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects　Tahara, A.; Tahara, N.; Yamagishi, S. I.; Honda, A.; Igata, S.; Nitta, Y.; Bekki, M.; Nakamura, T.; Sugiyama, Y.; Sun, J.; Takeuchi, M.; Shimizu, M.; Yamazaki, H.; Fukami, K.; Fukumoto, Y.　Int J Food Sci Nutr　68　1013-1020　2017　
• 原著論文　Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase　Uehara, S.; Shimizu, M.; Uno, Y.; Inoue, T.; Sasaki, E.; Yamazaki, H.　Drug Metab Dispos　45　497-500　2017　
• 原著論文　Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice　Shimizu, M.; Suemizu, H.; Mitsui, M.; Shibata, N.; Guengerich, F. P.; Yamazaki, H.　Xenobiotica　47　844-848　2017　
• 原著論文　Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers　Murayama, N.; Shimizu, M.; Kobayashi, K.; Kishimoto, I.; Yamazaki, H.　Drug Metab Lett　10　240-243　2017　
• 原著論文　Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules　Mori, K.; Saito, R.; Nakamaru, Y.; Shimizu, M.; Yamazaki, H.　Biopharm Drug Dispos　37　491-506　2016　
• 原著論文　 Assessment of protein binding of 5-hydroxythalidomide bioactivated in humanized mice with human P450 3A-chromosome or hepatocytes by two-dimensional electrophoresis/accelerator mass spectrometry. 　Yamazaki, H., Suemizu, H., Kazuki, Y., Oofusa, K., Kuribayashi, S., Shimizu, M., Ninomiya, S., Horie, T., Shibata, N., and Guengerich, F. P.　Chem. Res. Toxicol.　29　1279-1281　2016　
• 原著論文　Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling. 　Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H.　Xenobiotica　46　1049-1055　2016　
• 原著論文　Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors. 　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Biopharm. Drug Dispos.　37　310-313　2016　
• 原著論文　Individual differences in metabolic clearance of S-warfarin efficiently mediated by polymorphic marmoset cytochrome P450 2C19 in livers.　Uehara, S., Uno, Y., Inoue, T., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H.　Drug Metab. Dispos.　44　911-915　2016　
• 原著論文　Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing.　Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. 　Biopharm. Drug Dispos.　37　220-232　2016　
• 原著論文　Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. 　 Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. 　Gastroenterology　150　1171-1182　2016　
• 原著論文　Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). 　Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. 　Xenobiotica　46　163-168　2016　
• 総説　19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告　山崎浩史、清水万紀子　薬剤学　75　380　2015　
• 原著論文　Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. 　Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H.　Mol.Genet.Metab.Report　5　89-93　2015　
• 原著論文　Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms.　Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H.　Data in Brief　5　 642-645　2015　
• 原著論文　Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H.　Biopharm. Drug Dispos.　36　636-643　2015　
• 原著論文　Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole.　Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos.　43　1408-1416　2015　
• 原著論文　Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. 　Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. 　Radioisotopes　64　509-519　2015　
• 原著論文　Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. 　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Drug Metab. Dispos.　43　1119-1122　2015　
• 原著論文　Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.　Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H.　Regul.Toxicol.Pharmacol.　72　 71-76　2015　
• 原著論文　Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. 　Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H.　Biochem. Pharmacol.　95　110-114　2015　
• 原著論文　Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.　Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H.　Xenobiotica　45　881-886　2015　
• 原著論文　Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). 　Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos. 　43　735-742　2015　
• 原著論文　Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.　Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H.　Environ. Toxicol. Pharmacol.　39　1067-1073　2015　
• 原著論文　Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan.　Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. 　Xenobiotica　45　757-765　2015　
• 原著論文　Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. 　Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H.　Biopharm. Drug Dispos.　36　148-162　2015　
• 原著論文　Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. 　Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S.　J.Cardiovasc.Pharmacol.　65　 289-295　2015　
• 原著論文　Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.　Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. 　Drug Metab.Pharmacokinet.　30　64-69　2015　
• 原著論文　Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.　Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H.　Drug Metab.Pharmacokinet.　30　 70-74　2015　
• 原著論文　Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes.　Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H.　Clinica Chimica Acta.　441　71-74　2015　
• 原著論文　Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase.　Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Drug Metab. Dispos.　43　27-33　2015　
• 原著論文　Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. 　Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H.　Regul.Toxicol.Pharmacol.　70　468-473　2014　
• 原著論文　Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. 　Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H.　Regul.Toxicol.Pharmacol. 　70　214-221　2014　
• 原著論文　Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing.　Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H.　PLoS One　9　e100936　2014　
• 原著論文　Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.　Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H.　Biochem. Pharmacol.　90　159-165　2014　
• 原著論文　Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. 　Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H.　Clin.Kidney J.　7　329　2014　
• 原著論文　A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)　Ohyama, K., Shimizu, M., and Yamazaki, H.　Jpn. J. Pharm. Health Care Sci.　40　310-316　2014　
• 原著論文　Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.　Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R.　Brit.J. Clin. Pharmacol.　77　839-851　2014　
• 原著論文　Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor.　Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H.　Chem. Res.Toxicol.　27　304-308　2014　
• 原著論文　Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. 　Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H.　Xenobiotica　44　10-16　2014　
• 原著論文　Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline. 　Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K and Yamazaki H.　Xenobiotica　43　1037-1042　2013　
• 原著論文　Effects of ADH1C, ALDH2, and CYP2A6 polymorphisms on individual risk of tobacco-related lung cancer in male Japanese smokers. 　Shimizu, M., Ishii, Y., Okubo, M., Kunitoh, H., Kamataki, T., and Yamazaki, H.　J.Cancer Ther　4　 28-35　2013　
• 原著論文　 Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.　Uno, Y., Shimizu, M., and Yamazaki, H. 　 Biochem. Pharmacol　85　1837-1847　2013　
• 原著論文　The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver. 　Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F. P., and Yamazaki, H　J. Toxicol. Sci.　38　349-34　2013　
• 原著論文　 Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.　Tsukada, A., Suemizu, H., Murayama, N., Takano, R., Shimizu, M., Nakamura, M., and Yamazaki, H. 　Regul.Toxicol.Pharmacol.　65　 316-324　2013　
• 総説　Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities.　Yamazaki, H. and Shimizu, M. 　Biochem. Pharmacol.　85　1588-1593　2013　

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• ポスター発表　日本人におけるトリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3ハプロタイプの解析　牧野美紀、清水万紀子、徳山瑛美、梶谷綾、渡邊碧、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
• ポスター発表　日本人におけるトリメチルアミン尿症の原因となる新規フラビン含有モノオキシゲナーゼ3遺伝子変異の解析　徳山瑛美、清水万紀子、牧野美紀、梶谷綾、渡邊碧、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
• ポスター発表　ヒト肝細胞移植マウスおよびマーモセット生理学的薬物動態モデルを活用したチトクロムP450カクテル基質のヒト血中濃度推移予測　清水万紀子、三井満里奈、河野未来、上原正太郎、宇野泰広、鵜藤雅裕、井上貴史、佐々木えりか、末水洋志、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
• 口頭発表　ニコチン代謝酵素チトクロム P450 2A6 野生型および全欠損型遺伝子判定法の比較　岸本いずみ、清水万紀子、梶谷綾、山崎浩史　第70回聖マリアンナ医科大学医学会学術集会　川崎　2016/03/12
• ポスター発表　腎機能障害時における薬物間相互作用の予測：DPP-4阻害薬 テネリアを例として　清水秀俊、仲丸善喜、山崎浩史、久米俊行　第25回日本医療薬学会年会　横浜　2015/11/21～2015/11/23
• 特別講演・シンポジウム　Non-P450 drug-metabolizing enzyme flavin-containing monooxygenase: polymorphisms and interactions　Makiko Shimizu　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
• 特別講演・シンポジウム　Flavin-containing monooxygenase 3: Individual differences and drug interactions　Makiko Shimizu and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
• 口頭発表　日本人のトリメチルアミン尿症に関する大規模調査　千葉布季子、清水万紀子、牧野美紀、三觜菜々子、友田沙也加、山崎浩史　第69回聖マリアンナ医科大学医学会学術集会　川崎　2015/06/27
• 口頭発表　血液透析患者におけるFMD値とtrimethylamine-N-oxide、心血管病変との検討　西谷光広、上出亜希子、後藤厚子、武田麻有里、寺中久代、森内則子、山森満寿美、保志場紀子、澤﨑真由美、上田律子、大門正一郎、清水万紀子、山崎浩史　第60回日本透析医学会学術集会　横浜　2015/06/26～2016/06/28
• ポスター発表　当クリニックにおける魚臭症候群の一例を経験して　森内則子、西谷光広、澤﨑真由美、保志場紀子、山森満寿美、寺中久代、武田麻有里、後藤厚子、上出亜希子、上田律子、大門正一郎、清水万紀、山崎浩史　第60回日本透析医学会学術集会　横浜　2015/06/26～2016/06/28
• ポスター発表　Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C enzymes　Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
• ポスター発表　Molecular cloning, expression and functional characterization of marmoset cytochrome P450 2A6 　Shotaro Uehara, Yasuhiro Uno, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
• ポスター発表　Mutations of flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria　Makiko Shimizu and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
• ポスター発表　In Vivo R/S-Warfarin Metabolism Mediated by Polymorphic P450 2C19 in Cynomolgus Monkeys　Masahiro Utoh, Takahiro Yoshikawa, Makiko Shimizu, Kazuhide Iwasaki, Yasuhiro Uno, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
• ポスター発表　カニクイザル生理学的薬物動態モデルを活用したチトクロム P450 カクテル基質のヒト血中濃度推移予測　志田聡美、村山典恵、清水万紀子、鵜藤雅裕、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• 口頭発表　サリドマイド 1 次および 2 次酸化的代謝に関与するチトクロム P450 の種差　西山咲弥子、清水万紀子、上原正太郎、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• ポスター発表　日本人トリメチルアミン尿症の大規模詳細調査　千葉布季子、清水万紀子、徳山瑛美、牧野美紀、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• 口頭発表　カニクイザルシトクロムP450 2C9の 基質特異性に関する検討　保坂信哉、村山典恵、薩川正広、上原正太郎、清水万紀子、岩﨑一秀、岩野俊介、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• 口頭発表　チトクロム P450 2A6 野生型と全欠損型遺伝子の迅速判定法　清水万紀子、岸本いずみ、小山智生、澤谷怜、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• ポスター発表　抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差　大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也 、清水万紀子、秋元洋一、後藤晶子、○山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• 口頭発表　日本人のトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3遺伝子変異の解析　伊熊鞠佳、清水万紀子、三觜菜々子、友田沙也加、山崎浩史　第68回聖マリアンナ医科大学医学会学術集会　川崎　2014/12/11～2014/12/12
• 口頭発表　レボカルニチン製剤を使用した透析患者の血中トリメチルアミン濃度　山崎 浩史、清水万紀子、小篠 榮　第35回日本臨床薬理学会年会　松山　2014/12/04～2014/12/06
• 口頭発表　日本人集団から見出されたトリメチルアミン尿症の原因となるフラビン含有酸素添加酵素3遺伝子多型　清水万紀子、折口裕美、伊熊鞠佳、三觜菜々子、友田沙也加、山崎浩史　第35回日本臨床薬理学会年会　松山　2014/12/04～2014/12/06
• Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba, Hiroshi Yamazaki　Genetic polymorphisms in flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population　Makiko Shimizu, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
• ポスター発表　Oxidative metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by liver and brain microsomes from common marmosets　Shotaro Uehara, Norie Murayama, Makiko Shimizu, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
• ポスター発表　レボカルニチン投与時の透析患者におけるトリメチルアミンおよび N -酸化体の体内運命の検討　小泉綾乃、若林あかり、清水万紀子、小篠榮、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
• 口頭発表　サリドマイド代謝的活性化における霊長類チトクロム P450 の役割　西山咲弥子、清水万紀子、上原正太郎、宇野泰広、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
• ポスター発表　薬局の大規模データを用いたジクロフェナク局所皮膚適用製剤の副作用発現とリスク因子に関する検討　大山勝宏、高橋真二、福岡勝志、清水万紀子、山崎浩史　第24回日本医療薬学会年会　名古屋　2014/09/27～2014/09/28
• ポスター発表　透析患者のレボカルニチン（LC）投与時における内服薬と注射薬の血中トリメチルアミン（TMA）及びN-酸化体（TMAO）値への影響　小篠榮、前田弘美、井戸田昭子、久保和雄、鈴木敦、鈴木利昭、小泉綾乃、若林あかり、清水万紀子、山崎浩史　第59回日本透析医学会学術集会・総会　神戸　2014/06/13～2014/06/15
• ポスター発表　日本人集団において見出されたトリメチルアミン尿症の一因となるフラビン含有酸素添加酵素3遺伝子多型　清水万紀子、豊川千愛、折口裕美、村山典恵、山崎浩史　日本薬学会第134年会　熊本　2014/03/28～2014/03/30
• 口頭発表　レボカルニチン投与時の透析患者におけるトリメチルアミンおよびN-酸化体の体内動態の研究　小泉綾乃、清水万紀子、若林あかり、村山典恵、小篠榮、山崎浩史　第66回聖マリアンナ医科大学医学会　川崎　2013/12/12～2013/12/13
• ポスター発表　日本人トリメチルアミン尿症の一因となるフラビン含有酸素添加酵素3遺伝子多型　清水万紀子、加瀬愛幸、石井有紀、山﨑美穂、山崎浩史　第34回日本臨床薬理学会学術総会　東京　2013/12/04～2013/12/06
• ポスター発表　ヒトフラビン含有酸素添加酵素3を介する医薬品相互作用　山崎浩史、 清水万紀子　第34回日本臨床薬理学会学術総会　東京　2013/12/04～2013/12/06
• ポスター発表　ヒト肝移植マウスを活用した生理学的薬物動態モデルによる医薬・化学品のヒト血中濃度推移予測　曽田重人、宮口貴守、志田聡美、鈴木佑貴、安達昂一朗、高野良治、清水万紀子、村山典恵、末水洋志、山崎浩史　第57回日本薬学会関東支部会　東京　2013/10/26
• ポスター発表　ラットおよびヒト肝移植マウスを用いた農薬の実測および推定血漿中濃度に基づくリスク評価に関する研究　山下真直、西山咲弥子、小林健太、菅原大輔、杉山洋介、高野良治、村山典恵、清水万紀子、末水洋志、山崎浩史　第57回日本薬学会関東支部会　東京　2013/10/26
• ポスター発表　Flavin-containing monooxygenase 3 (FMO3) genotype and phenotype in a Japanese cohort　Makiko Shimizu, Elizabeth Shephard, Ian R. Phillips, Hiroshi Yamazaki　28th JSSX Annual Meeting　東京　2013/10/09～2013/10/10
• ポスター発表　Relative contribution of cytochrome P450 and flavin-containing monoxygenase to the metabolism of the Dipeptidyl Peptidase-4 Inhibitor, Teneligliptine by human liver microsomes　Tomomi Taniguchi-Takizawa, Yoshinobu Nakamaru, Makiko Shimizu, Hiroshi Yamazaki, Toshiyuki Kume　28th JSSX Annual Meeting　東京　2013/10/09～2013/10/10
• 口頭発表　成長に伴う薬物酸化酵素フラビン含有モノオキシゲナーゼの個人変動　清水万紀子、山崎浩史　次世代を担う創薬・医療薬理シンポジウム2013　熊本　2013/08/31
• ポスター発表　Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population　Makiko Shimizu, Elizabeth Shephard, Ian R. Phillips, Hiroshi Yamazaki　18th International Conference on Cytochrome P450 ~Biochemistry, Biophysics, Biotechnology　Washington, USA　2013/06/18～2013/06/23
• 口頭発表　日本人幼児および小児トリメチルアミン尿症をもたらすフラビン含有モノオキシゲナーゼ3の解析　石井有紀、清水万紀子、加瀬愛幸、山﨑美穂、村山典恵、吉田さやか、山崎浩史　第65回聖マリアンナ医科大学医学会　川崎　2013/06/05

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