教員

村山 典恵講師 /  last update : 2016.07.07

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プロフィール

研究者名
村山 典恵(ムラヤマ ノリエ)
所属
薬物動態学研究室
担当科目
 
職位
講師
学位
 
  • がん増殖と悪性化への分子機構 山崎浩史、村山典恵 第12章化学発がん  化学同仁 2012 
  • 原著論文 Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells Sugiyama, I., Murayama, N., Kuroki, A., Kota, J., Iwano, S., Yamazaki, H., and Hirota, T Xenobiotica 46  765-774 2016 
  • 原著論文 Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing. Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y.  Biopharm. Drug Dispos. 37 220-232 2016 
  • 原著論文 Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5. Hum. Okubo, M., Morita, S., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H.  Psychopharmacol.Clin.Exp. 31 93-102 2016 
  • 原著論文 Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P450 2D6 and flavin-containing monooxygenase 3. Hum. Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H.  Psychopharmacol.Clin.Exp. 31 83-92 2016 
  • 原著論文 In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans.  Sekiguchi, K., Kanazu, T., Murayama, N., Yamazaki, H., and Yamaguchi, T. Xenobiotica 46 495-502 2016 
  • 原著論文 Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene by human cytochrome P450 2A13.  317. Shimada, T., Takenaka, S., Murayama, N., Kramlinger, V. M., Kim, J.-H., Kim, D., Foroozesh, M. K., Yamazaki, H., Guengerich, F. P., and Komori, M. Xenobiotica 46  211-224 2016 
  • 総説 Regioselective hydroxylation of steroid hormones by human cytochromes P450.  Niwa, T., Murayama, N., Imagawa, Y., and Yamazaki, H. Drug Metab. Rev. 47 89-110 2015 
  • 原著論文 Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances. Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. Biopharm. Drug Dispos. 36 636-643 2015 
  • 原著論文 Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies.  Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T.  Radioisotopes 64 509-519 2015 
  • 原著論文 Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase.  Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H.  Drug Metab. Dispos. 43 1119-1122 2015 
  • 原著論文 Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling. Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H. Regul.Toxicol.Pharmacol. 72  71-76 2015 
  • 原著論文 Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling. Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H. Xenobiotica 45 881-886 2015 
  • 原著論文 Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).  Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H.  Drug Metab. Dispos.  43 735-742 2015 
  • 原著論文 Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling. Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H. Environ. Toxicol. Pharmacol. 39 1067-1073 2015 
  • 原著論文 Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan. Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H.  Xenobiotica 45 757-765 2015 
  • 原著論文 CYP2D44 polymorphisms in cynomolgus and rhesus macaques. Uno, Y., Uehara, S., Kohara, S., Osada, N., Murayama, N., and Yamazaki,H. Mol.Biol.Rep. 42 1149–1155 2015 
  • 原著論文 Oxidation of acenaphthene and acenaphthylene by human cytochrome P450 enzymes. Shimada, T., Takenaka, S., Murayama, N., Yamazaki, H., Kim, J. H., Kim, D., Yoshimoto, F. K., Guengerich, F. P., and Komori, M. Chem. Res.Toxicol. 28  268-278 2015 
  • 原著論文 Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays. Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H. Drug Metab.Lett. 9 3-7 2015 
  • 原著論文 A. Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models.  Watanabe, Y., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Murayama, N., Sugiyama, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama Basic Clin.Pharmacol.Toxicol. 116 468-475 2015 
  • 原著論文 Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole, and metoprolol, in cynomolgus monkeys using in vitro-in vivo correlation. Koyanagi, T., Nakanishi, Y., Murayama, N., Yamaura, Y., Ikeda, K., Yano, K., Uehara, S., Utoh, M., Kim, S., Uno, Y., and Yamazaki, H. Xenobiotica 45 312-321 2015 
  • 原著論文 Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.  Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H. Drug Metab.Pharmacokinet. 30 130-132 2015 
  • 原著論文 Immunochemical quantification of cynomolgus CYP2J2, CYP4A, and CYP4F enzymes in liver and small intestine. Uehara, S., Murayama, N., Nakanshi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y.  Xenobiotica 45 124-130 2015 
  • 原著論文 Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients. Okubo, M., Murayama, N., Miura, J., Chiba, Y., and Yamazaki, H. Biochem. Pharmacol. 93 104-109 2015 
  • 原著論文 Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase. Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H.  Drug Metab. Dispos. 43 27-33 2015 
  • 原著論文 Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation. Niwa T, Yasumura M, Murayama N and Yamazaki H. Drug Metab.Lett. 8 43-50 2014 
  • 原著論文 CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques.  Uno, Y., Matsushita, A., Shukuya, M., Matsumoto, Y., Murayama, N., and Yamazaki, H.  Biochem. Pharmacol. 91  242-248 2014 
  • 原著論文 Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism. Uno, Y., Uehara, S., Kohara, S., Murayama, N., and Yamazaki, H. Drug Metab. Dispos. 42 1407-1410 2014 
  • 原著論文 Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.  Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H. Regul.Toxicol.Pharmacol.  70 214-221 2014 
  • 原著論文 Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing. Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H. PLoS One 9 e100936 2014 
  • 原著論文 K. Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 Inhibitor teneligliptin: an open-label study in healthy white subjects in Germany. Nakamaru, Y., Hayashi, Y., Sekine, M., Kinoshita, S., Thompson, J., Kawaguchi, A., Davies, M., Jurgen, Heuer H., Yamazaki, H., and Akimoto Clin.Ther. 36 760-769 2014 
  • 原著論文 Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig. Biopharm. Higashi, E., Ando, A., Iwano, S., Murayama, N., Yamazaki, H., and Miyamoto, S.  Drug Dispos. 35 313-320 2014 
  • 原著論文 Yajima, K., Uno, Y., Murayama, N., Uehara, S., Shimizu, M., Nakamura, C., Iwasaki, K., Utoh, M., and Yamazaki, H. Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450.  Drug Metab. Dispos 42 867-871 2014 
  • 原著論文 Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. Uehara, S., Murayama, N., Nakanishi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y. Xenobiotica 44 769-774 2014 
  • 原著論文 Voriconazole metabolism, toxicity and the effect of cytochrome P450 2C19 genotype.  Zonios, D., Yamazaki, H., Murayama, N., Natrarajan, V., Palmore, T., Childs, R., Skinner, J., and Bennett, J. J.Infect.Dis. 209 1941-1948 2014 
  • 原著論文 Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor. Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H. Chem. Res.Toxicol. 27 304-308 2014 
  • 原著論文 Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation.  Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H. Xenobiotica 44 10-16 2014 

研究業績(学会発表等)

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  • ポスター発表 抗てんかん薬オクスカルバゼピンの代謝酵素誘導能に関する研究 黒木彩加、村山典恵、杉山育男、岩野俊介、山崎浩史、廣田孝司 日本薬学会第136年会 横浜 2016/03/26~2016/03/29
  • ポスター発表 向精神病薬カルバマゼピンがもたらすヒトP4503A酵素との薬物相互作用 村山典恵、倉林優貴、日川美紀子、大久保真穂、山崎浩史 日本薬学会第136年会 横浜 2016/03/26~2016/03/29
  • ポスター発表 マーモセットあるいはカニクイザル肝細胞を用いた薬物暴露によるチトクロムP450誘導の評価 鈴木貴子、上原正太郎、村山典恵、宇野泰広、矢島加奈子、鵜藤雅裕、井上貴史、佐々木えりか、山崎浩史 日本薬学会第136年会 横浜 2016/03/26~2016/03/29
  • 特別講演・シンポジウム ヒト放射線内部被曝線量評価の実際およびAPDDの提案 池田敏彦、村山典恵、山崎浩史 北里-APDD合同シンポジウム -ヒトRI試験の実施指針- 東京 2016/03/14
  • ポスター発表 In Vivo Model for Predicting Organophosphate Toxicity using Humanized-Liver TK-NOG Mouse Hiroshi Suemizu, Miyuki Kuronuma, Kenji Kawai, Norie Murayama, Masato Nakamura and Hiroshi Yamazaki The Society of Toxicology 55th Annual Meeting New Orleans, USA 2016/03/13~2016/03/17
  • ポスター発表 Comparison of catalytic properties in cytochrome P450 3A4 and 3A5 for various compounds including endogenous steroid hormones by molecular docking simulation Toshiro Niwa, Norie Murayama, Yurie Imagawa, Hiroshi Yamazaki 30th JSSX Annual Meeting 東京 2015/11/12~2015/11/14
  • ポスター発表 Induction of drug metabolizing enzymes by thalidomide dependent on pregnane X receptor (PXR) in human livers as evident using PXR-knockout HepaRG cells Norie Murayama, Kanako Yajima, and Hiroshi Yamazaki 30th JSSX Annual Meeting 東京 2015/11/12~2015/11/14
  • ポスター発表 Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C enzymes Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno, Hiroshi Yamazaki 19th International Conference on Cytochrome P450 東京 2015/06/12~2015/06/15
  • ポスター発表 Human cytochromes P450-mediated regioselective hydroxylation of steroid hormones Toshiro Niwa, Norie Murayama, Yurie Imagawa, and Hiroshi Yamazaki 19th International Conference on Cytochrome P450 東京 2015/06/12~2015/06/15
  • ポスター発表 Molecular cloning, expression and functional characterization of marmoset cytochrome P450 2A6  Shotaro Uehara, Yasuhiro Uno, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki 19th International Conference on Cytochrome P450 東京 2015/06/12~2015/06/15
  • ポスター発表 The modulation of physiological condition for expression of P450s in differential cryopreserved HepaRG cells Norie Murayama, Kanako Yajima, Hiroshi Yamazaki 19th International Conference on Cytochrome P450 東京 2015/06/12~2015/06/15
  • ポスター発表 薬物代謝型cytochrome P450及びステロイド代謝酵素によるステロイド代謝 丹羽俊朗、村山典恵、今川友里恵、山崎浩史 日本薬剤学会第30年会 長崎 2015/05/21~2015/05/23
  • ポスター発表 Cytochrome P450 (CYP、P450) 3A4及びCYP3A5を含むヒト代謝型P450に対する各種抗真菌薬の相互作用 今川友里恵、村山典恵、山崎浩史、丹羽俊朗 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • ポスター発表 Cytochrome P450 (CYP、P450) 3A4及びCYP3A5を含む各種ヒトP450によるステロイド代謝 丹羽俊朗、村山典恵、今川友里恵、山崎浩史 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • ポスター発表 カニクイザル生理学的薬物動態モデルを活用したチトクロム P450 カクテル基質のヒト血中濃度推移予測 志田聡美、村山典恵、清水万紀子、鵜藤雅裕、宇野泰広、山崎浩史 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • 口頭発表 サリドマイドによるヒトP450酵素自己誘導機構に及ぼす要因 村山典恵、矢島加奈子、柴田哲男、鵜藤雅裕、山崎浩史 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • 口頭発表 カニクイザルシトクロムP450 2C9の 基質特異性に関する検討 保坂信哉、村山典恵、薩川正広、上原正太郎、清水万紀子、岩﨑一秀、岩野俊介、宇野泰広、山崎浩史 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • ポスター発表 抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差 大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也 、清水万紀子、秋元洋一、後藤晶子、○山崎浩史 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • 口頭発表 抗精神病薬リスペリドン投与日本人患者における血漿中薬物濃度の個人差 大久保真穂、村山典恵、森田翔子、森亜沙美、倉林優貴、秋元洋一、後藤晶子、山崎浩史 日本薬学会第135年会 神戸 2015/03/25~2015/03/28
  • ポスター発表 Warfarin metabolism mediated by polymorphic P450 2C19 in cynomolgus monkeys Hiroshi Yamazaki, Yasuhiro Uno, Mitsunori Shukuya, Takahiro Yoshikawa, Yasuka Matsumoto, Akinori Matsushita, Norie Murayama, Koichiro Fukuzaki, Masahiro Utoh 19th North American ISSX/ 29th JSSX Annual Meeting San Francisco 2014/10/19~2015/10/23
  • ポスター発表 Roles of auto-induction of human P450 3A enzymes involved in the teratogenicity of thalidomide Norie Murayama, Christophe Chesné, F. Peter Guengerich, Hiroshi Yamazaki 19th North American ISSX/ 29th JSSX Annual Meeting San Francisco 2014/10/19~2015/10/23
  • ポスター発表 Oxidative metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by liver and brain microsomes from common marmosets Shotaro Uehara, Norie Murayama, Makiko Shimizu, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki 19th North American ISSX/ 29th JSSX Annual Meeting San Francisco 2014/10/19~2015/10/23
  • ポスター発表 Effects of CYP2D6 and CYP3A5 genotypes and co-administrated drugs on the metabolic clearance of antidepressant mirtazapine Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba, Hiroshi Yamazaki 19th North American ISSX/ 29th JSSX Annual Meeting San Francisco 2014/10/19~2015/10/23
  • ポスター発表 抗うつ薬ミルタザピンの代謝消失に関わる薬物代謝酵素 森亜沙美、大久保真穂、成田桃子、森田翔子、村山典恵、三浦淳、千葉泰二、山崎浩史 第58回日本薬学会関東支部大会 東京 2014/10/04
  • ポスター発表 ヒト肝移植マウスを活用した生理学的薬物動態モデルによるフタル酸ビス2エチルヘキシルのヒト体内動態予測 安達昂一郎、宮口貴守、村山典恵、末水洋志、山崎浩史 第58回日本薬学会関東支部大会 東京 2014/10/04
  • ポスター発表 Drug interaction of antifungal agents against cytochrome P450s Toshiro Niwa, Yurie Imagawa, Motohiro Yasumura, Norie Murayama, Hiroshi Yamazaki 12th International Symposium on Cytochrome P450 Biodiversity & Biotechnology 京都 2014/09/24~2014/09/28
  • 口頭発表 ヒト肝細胞HepaRGにおける環境化学物質の細胞毒性と薬物代謝酵素誘導能について 曽根秀子、村山典恵、王文龍、曾洋、南齋ひろ子、曾勤、山崎浩史 フォーラム2014 衛生薬学・環境トキシコロジー つくば 2014/09/19~2014/09/20
  • 口頭発表 カニクイザル硫酸転移酵素の同定・解析 宇野泰広、村山典恵、山崎浩史 第157回日本獣医学会学術集会 札幌 2014/09/09~2014/09/12
  • 口頭発表 代謝酵素遺伝子多型および併用薬が抗うつ薬ミルタザピンの代謝消失に及ぼす影響 森田翔子、大久保真穂、森亜沙美、村山典恵、三浦淳、千葉泰二、山崎浩史 第67回聖マリアンナ医科大学医学会学術集会 川崎 2014/07/10~2014/07/11

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