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Introduction of Laboratories

Department of Drug Metabolism and Pharmacokinetics


Hiroshi Yamazaki, PhD.
Norie Murayama, PhD.
Makiko Shimizu, PhD.


Processes in pharmacokinetics, including drug absorption, distribution, metabolism (biotransformation) and excretion, are influenced by many factors belonging to drugs and their dosage forms, to physiological or genetic variables of the individual patients, and to effects of other drugs taken concurrently.

We focuse characteristics of drug-metabolizing enzymes (such as cytochromes P450, flavin-containing monooxygenases, and UDP-glucuronosyltransferases) and of pharmacokinetics of clinically important medicines. Both phenotype and genotype studies for patients are ongoing in this laboratory.

Good pharmaceutical administration has always meant correct dosages for individual patients. However, today it is not limited to merely the careful dispensing of drugs, but also includes active involvement in pharmaceutical cure at patient's bedside and home. Our department, therefore, is committed to training students to be professional pharmacists capable of contribution all such patient-oriented needs.