種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation." "Echizen H., Hanaoka K., Shimamoto K., Hibi R., Toma-Fukai S., Ohno H., Sasaki E., Komatsu T., Ueno T., Tsuchiya Y., Watanabe Y., Otsuka T., Saito H., Nagatoishi S., Tsumoto K., Kojima H., Okabe T., Shimizu T., Urano Y." "Sci Rep" 13 16456 2023 10.1038/s41598-023-43536-6 https://pubmed.ncbi.nlm.nih.gov/37777556/ 原著論文 "Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism" "Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya" "Int J Mol Sci " 24 9982 2023 10.3390/ijms24129982 https://pubmed.ncbi.nlm.nih.gov/37373128/ 原著論文 "Angiogenesis in the Outer Membrane of Chronic Subdural Hematomas through Thrombin-Cleaved Osteopontin and the Integrin α9 and Integrin β1 Signaling Pathways" "Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Satoru Honma, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi" Biomedicines 11 1440 2023 10.3390/biomedicines11051440 https://pubmed.ncbi.nlm.nih.gov/37239111/ 原著論文 "Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants" "Shingo Kasamatsu , Hiroyasu Tsutsuki, Tomoaki Ida, Tomohiro Sawa, Yasuo Watanabe, Takaaki Akaike, Hideshi Ihara" "Nitric Oxide . " 120 44-52 2022 10.1016/j.niox.2022.01.004 https://pubmed.ncbi.nlm.nih.gov/35033681/ 原著論文 "Sequential expression of neutrophil chemoattractants in cerebrospinal fluid after subarachnoid hemorrhage. " "Koji Osuka, Yasuo Watanabe, Chiharu Suzuki, Kenichiro Iwami, Shigeru Miyachi" "Journal of neuroimmunology " 357 "577610-577610 " 2021 10.1016/j.jneuroim.2021.577610 https://pubmed.ncbi.nlm.nih.gov/34030107/ 原著論文 "Sequential Expression of Chemokines in Chronic Subdural Hematoma Fluids after Trepanation Surgery. " "Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Takahiro Nakura, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi" "Journal of neurotrauma" 38 1979-1987 2021 10.1089/neu.2020.7401 https://pubmed.ncbi.nlm.nih.gov/33497585/ 総説 "Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal " "Tsuyoshi Takata, Shoma Araki, Yukihiro Tsuchiya, Yasuo Watanabe" "Int J Mol Sci" 21 8750 2020 10.3390/ijms21228750 https://www.mdpi.com/1422-0067/21/22/8750 原著論文 "PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates" "Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I." iScience 23 101727 2020 10.1016/j.isci.2020.101727 https://pubmed.ncbi.nlm.nih.gov/33205029/ 総説（表紙：関連リンク） "Coordination between Calcium/Calmodulin-Dependent Protein Kinase II and Neuronal Nitric Oxide Synthase in Neurons" " Shoma Araki, Koji Osuka, Tsuyoshi Takata,Yukihiro Tsuchiya, Yasuo Watanabe" "Int J Mol Sci" 21 7997- 2020 10.3390/ijms21217997 https://www.mdpi.com/1422-0067/21/21 総説 "Persulfide signaling in stress-initiated CaM kinase response." "Tsuyoshi Takata, Shoma Araki, Yukihiro Tsuchiya, Yasuo Watanabe" "Antioxidants & redox signaling" 33 1308-1319 2020 10.1089/ars.2020.8138 https://www.ncbi.nlm.nih.gov/pubmed/32460522 原著論文 "Expression of high mobility group B1 and toll-like receptor-nuclear factor κB signaling pathway in chronic subdural hematomas" "Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Kenichiro Iwami, Shigeru Miyachi, Masakazu Takayasu" "PloS one " "15(6) " " e0233643 " 2020 10.1371/journal.pone.0233643 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263617 原著論文 "The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation" "Takata T, Tsukuda A, Tsuchiya Y, Akaike T, Watanabe Y." "Nitric Oxide" 86 68–75 2019 10.1016/j.niox.2019.02.008 https://www.sciencedirect.com/science/article/pii/S1089860318303355?dgcid=author 原著論文 "Reactive sulfur species impair Ca2+/calmodulin-dependent protein kinase II via polysulfidation" "Araki S, Takata T, Tsuchiya Y, Watanabe Y." "Biochem. Biophys. Res. Commun. " 508 550-555 2019 10.1016/j.bbrc.2018.11.134 https://www.ncbi.nlm.nih.gov/pubmed/30509490 原著論文 "Redox regulation of Ca2+/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue" "Takata T, Kimura J, Ihara H, Hatano N, Tsuchiya Y, Watanabe Y." "Free Radic. Biol. Med. " 130 99-106 2019 10.1016/j.freeradbiomed.2018.10.440 https://www.ncbi.nlm.nih.gov/pubmed/30394289 原著論文 "Expression of Autophagy Signaling Molecules in the Outer Membranes of Chronic Subdural Hematomas." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M." "J. Neurotrauma" 36 403-407 2019 "10.1089/neu.2018.5626 " "https://www.ncbi.nlm.nih.gov/pubmed/30106666 " 原著論文 "Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons." "Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H." "Biochem. Biophys. Res. Commun. " 495 2165-2170 2018 10.1016/j.bbrc.2017.12.088 https://www.ncbi.nlm.nih.gov/pubmed/29258821 原著論文 "Subarachnoid hemorrhage induces neuronal nitric oxide synthase phosphorylation at Ser1412 in the dentate gyrus of the rat brain." "Wada K, Osuka K, Watanabe Y, Usuda N, Fukasawa M, Araki Y, Okamoto S, Wakabayashi T." "Nitric Oxide" 81 67-74 2018 10.1016/j.niox.2017.10.007 https://www.ncbi.nlm.nih.gov/pubmed/29074292 原著論文 "Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics." "Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H." "Nat Commun. " 8 1177 2017 10.1038/s41467-017-01311-y https://www.ncbi.nlm.nih.gov/pubmed/29079736 原著論文 "Expression of Caspase Signaling Components in the Outer Membranes of Chronic Subdural Hematomas." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, Watabe T, Takayasu M." "J Neurotrauma. " 34 3192-3197 2017 10.1089/neu.2017.5051 https://www.ncbi.nlm.nih.gov/pubmed/28661222 原著論文 "Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue." "Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y." "Biochem J. " 474 2547-2562. 2017 10.1042/BCJ20170092 http://www.usaco.co.jp/itemview/template44_6_25011.html 原著論文 "Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation." "Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T." "Biochem J. " 474 1149-1162. 2017 10.1042/BCJ20160999 https://www.ncbi.nlm.nih.gov/pubmed/28126743 原著論文 "Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide." "Hanaoka K, Sasakura K, Suwanai Y, Toma-Fukai S, Shimamoto K, Takano Y, Shibuya N, Terai T, Komatsu T, Ueno T, Ogasawara Y, Tsuchiya Y, Watanabe Y, Kimura H, Wang C, Uchiyama M, Kojima H, Okabe T, Urano Y, Shimizu T, Nagano T." "Sci Rep. " 7 40227. 2017 10.1038/srep40227 https://www.ncbi.nlm.nih.gov/pubmed/28079151 原著論文 "1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides." "Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y." "Free Radic Biol Med." 104 118-128. 2017 10.1016/j.freeradbiomed.2016.12.047 https://www.ncbi.nlm.nih.gov/pubmed/28049024 原著論文 "Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, Watabe T, Takayasu M." "J. Neurotrauma." 34 1996-2000 2017 10.1089/neu.2016.4623 https://www.ncbi.nlm.nih.gov/pubmed/28027695 原著論文 "Activation of Nuclear Factor-kappa B in Endothelial Cells of Chronic Subdural Hematoma Outer Membranes." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Takeuchi M, Takayasu M." "Neurosurgery. " 80 571-578. "2017 " 10.1093/neuros/nyw100 https://www.ncbi.nlm.nih.gov/pubmed/28362919 原著論文 "Activation of STAT3 in endothelial cells of chronic subdural hematoma outer membranes" "Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Watabe T, Takayasu M." "World Neurosurg." 91 376-382 2016 10.1016/j.wneu.2016.04.025 http://www.ncbi.nlm.nih.gov/pubmed/27102635 総説 活性イオウ分子の分子標的 渡邊泰男 日本薬理学雑誌 147 285-289 2016 10.1254/fpj.147.285 https://www.jstage.jst.go.jp/article/fpj/147/5/147_285/_article/-char/ja/ 原著論文 "Expressions of Mitogen-Activated Protein Kinases in Chronic Subdural Hematoma Outer membranes" "Aoyama M, Osuka K, Usuda N, Watanabe Y, Kawaguchi R, Nakura T, Takayasu M." "J Neurotrauma." 15 1064-1070 2015 10.1089/neu.2014.3594 http://www.ncbi.nlm.nih.gov/pubmed/25496293 原著論文 "Increased ICP promotes CaMKII-mediated phosphorylation of neuronal NOS at Ser847 in the hippocampus immediately after subarachnoid hemorrhage" "Makino K, Osuka K, Watanabe Y, Usuda N, Hara M, Aoyama M, Takayasu M, Wakabayashi T." "Brain Res." 1616 19-25 2015 10.1016/j.brainres.2015.04.048 http://www.ncbi.nlm.nih.gov/pubmed/25940762 原著論文 "Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides" "Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y." "Chem Res Toxicol." 28 1796-1802 2015 10.1021/acs.chemrestox.5b00245 http://www.ncbi.nlm.nih.gov/pubmed/26304691 原著論文 "Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons." "Kasamatsu S, Watanabe Y, Sawa T, Akaike T, Ihara H." "Biochem J." 459 251-263 2014 10.1042/BJ20131262 http://www.ncbi.nlm.nih.gov/pubmed/24499461 原著論文 "Eotaxin-3 activates Smad through the TGF-β1 pathway in chronic subdural hematoma outer membranes." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M." "J Neurotrauma." 31 1451-1456 2014 10.1089/neu.2013.3195 http://www.ncbi.nlm.nih.gov/pubmed/24684589 原著論文 "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling." "Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T." "Proc Natl Acad Sci U S A." 111 7606-7611 2014 10.1073/pnas.1321232111 http://www.ncbi.nlm.nih.gov/pubmed/24733942 原著論文 "Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage" "Osuka K, Watanabe Y, Aoyama M, Nakura T, Matsuo N, Takayasu M." "J Neuroinflammation." 11 142 2014 10.1186/s12974-014-0142-2 http://www.ncbi.nlm.nih.gov/pubmed/25125049 原著論文 "Activation of JAK-STAT3 signaling pathway in chronic subdural hematoma outer membranes" "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Shima H, Takeuchi M, Yasuda M, Takayasu M." "Neurosci Lett." 534 166−170 2013 10.1016/j.neulet.2012.11.011 http://www.ncbi.nlm.nih.gov/pubmed/23174178 原著論文 "90-kDa ribosomal S6 kinase 1 is inhibited by S-glutathionylation of its active-site cysteine residue during oxidative stress " "Takata T, Tsuchiya Y, Watanabe Y." "FEBS Lett." 587 1681-1686 2013 10.1016/j.febslet.2013.04.017 http://www.ncbi.nlm.nih.gov/pubmed/23624076 原著論文 "Nitric oxide enhances increase in cytosolic Ca2+ and promotes nicotine-triggered MAPK pathway in PC12 cells." "Kajiwara A, Tsuchiya Y, Takata T, Nyunoya M, Nozaki N, Ihara H, Watanabe Y." "Nitric Oxide." 34 3−9 2013 10.1016/j.niox.2013.04.002 http://www.ncbi.nlm.nih.gov/pubmed/23624270 原著論文 "Phosphorylation of neuronal nitric oxide synthase at Ser1412 in the dentate gyrus of rat brain after transient forebrain ischemia." "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Takayasu M." "Neurochem Int." 63 269-274 2013 10.1016/j.neuint.2013.06.011 http://www.ncbi.nlm.nih.gov/pubmed/23806217 原著論文 "Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage." "Osuka K, Watanabe Y, Yasuda M, Takayasu M." "Neurosci Lett." 514 2−5 2012 10.1016/j.neulet.2011.12.041 http://www.ncbi.nlm.nih.gov/pubmed/22230897 原著論文 "Nitric oxide prevents phosphorylation of neuronal nitric oxide synthase at Serine1412 by inhibiting the Akt/PKB and CaM-K II signaling pathways" "Song T, Hatano N, Sugimoto K, Horii M, Yamaguchi F, Tokuda M, Miyamoto Y, Kambe T, Watanabe Y." "Int J Mol Med." 30 15-20 2012 10.3892/ijmm.2012.971 http://www.ncbi.nlm.nih.gov/pubmed/22576624 原著論文 "Real-time monitoring of liver damage during ischemia-reperfusion using a nitric oxide-selective sensor in rat liver" "Nakagawa A, Yokoyama Y, Suzuki H, Shoji K, Watanabe Y, Imamura A, Kokuryo T, Nagino M." "Br J Surg." 99 1120-1128 2012 10.1002/bjs.8817 http://www.ncbi.nlm.nih.gov/pubmed/22622706 原著論文 "Activation of Ras/MEK/ERK signaling in chronic subdural hematoma outer membranes" "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Aoyama M, Niwa A, Nakura T, Takayasu M." "Brain Res." 13 98-103 2012 10.1016/j.brainres.2012.10.013 http://www.ncbi.nlm.nih.gov/pubmed/23063714 原著論文 "Calcium/calmodulin-dependent protein kinases as potential targets of nitric oxide" "Takata T, Kimura J, Tsuchiya Y, Naito Y, Watanabe Y." "Nitric Oxide." 25 145-152 2011 10.1016/j.niox.2011.01.004 http://www.ncbi.nlm.nih.gov/pubmed/21255668 原著論文 "Activation of PI3 kinase / Akt signaling in chronic subdural hematoma outer membranes. " "Funai M, Osuka K, Usuda N, Atsuzawa K, Inukai T, Yasuda M, Watanabe Y, Takayasu M." "J Neurotrauma." 28 1127-1131 2011 10.1089/neu.2010.1498 http://www.ncbi.nlm.nih.gov/pubmed/21309701 原著論文 "Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation" "Butturini E, Cavalieri E, de Prati AC, Darra E, Rigo A, Shoji K, Murayama N, Yamazaki H, Watanabe Y, Suzuki H, Mariotto S." "PLoS One." 6 e20174 2011 10.1371/journal.pone.0020174 http://www.ncbi.nlm.nih.gov/pubmed/21625597 原著論文 "Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells" "Miyamoto Y, Sakai R, Maeda C, Takata T, Ihara H, Tsuchiya Y, Watanabe Y." "Nitric Oxide." 25 344-349 2011 10.1016/j.niox.2011.06.006 http://www.ncbi.nlm.nih.gov/pubmed/21742048 原著論文 "Activation of STAT1 in neurons following spinal cord injury in mice" "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yasuda M, Aoshima C, Wakabayashi T, Takayasu M." "Neurochem Res. " 36 2236-2243 2011 10.1007/s11064-011-0547-6 http://www.ncbi.nlm.nih.gov/pubmed/21833847 原著論文 "Hypothermia enhances the colocalization of calmodulin kinase IIα with neuronal nitric oxide synthase in the hippocampus following cerebral ischemia" "Hayashi S, Osuka K, Watanabe Y, Yasuda M, Takayasu M, Wakabayashi T." "Neurosci Lett. " 505 228-232 2011 10.1016/j.neulet.2011.10.013 http://www.ncbi.nlm.nih.gov/pubmed/22015767 原著論文 "Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage. " "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, Takayasu M." "Brain Res. " 1332 12-19. 2010 10.1016/j.brainres.2010.03.046 https://www.ncbi.nlm.nih.gov/pubmed/20307504 原著論文 "Inactivation of Ca2+/Calmodulin-dependent Protein Kinase I by S-Glutathionylation of the Active-site Cysteine Residue." "Kambe T., Song T., Takata T., Hatano N., Miyamoto Y., Nozaki N., Naito Y., Tokumitsu H., Watanabe Y. " "FEBS Lett. " 584 2478-2484 2010 10.1016/j.febslet.2010.04.059. http://www.ncbi.nlm.nih.gov/pubmed/20420839 原著論文 "Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage. " "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yoshida J, Takayasu M." "J Neurotrauma. " 26 1157-65. 2009 10.1089/neu.2008-0836 https://www.ncbi.nlm.nih.gov/pubmed/19226196 原著論文 "Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. " "Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y. " "Biochem J. " 412 "223-31. " 2008 10.1042/BJ20071195 https://www.ncbi.nlm.nih.gov/pubmed/18271754 原著論文 "Activation of endothelial nitric oxide synthase following spinal cord injury in mice. " "Osuka K, Watanabe Y, Takagi T, Usuda N, Atsuzawa K, Yoshida J, Takayasu M. " "Neurosci Lett." 436 "265-8. " 2008 10.1016/j.neulet.2008.03.039 https://www.ncbi.nlm.nih.gov/pubmed/18400399 原著論文 "p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. " "Song T, Sugimoto K, Ihara H, Mizutani A, Hatano N, Kume K, Kambe T, Yamaguchi F, Tokuda M, Watanabe Y. " " Biochem J. " 401 391-8. 2007 https://www.ncbi.nlm.nih.gov/pubmed/16984226 原著論文 "Nitric oxide production in the ventilatory muscles in response to acute resistive loading. " "Vassilakopoulos T, Govindaraju K, Parthenis D, Eidelman DH, Watanabe Y, Hussain SN. " "Am J Physiol Lung Cell Mol Physiol." 292 L1013-22. 2007 https://www.ncbi.nlm.nih.gov/pubmed/17189323 原著論文 "Phosphorylation of neuronal nitric oxide synthase at Ser847 in the nucleus intermediolateralis after spinal cord injury in mice. " "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Aoshima C, Yamauchi K, Takayasu M, Yoshida J. " "Neuroscience. " 24 1-7 2007 https://www.ncbi.nlm.nih.gov/pubmed/17258865 原著論文 "Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells. " "Araki N, Egami Y, Watanabe Y, Hatae T. " "Exp Cell Res. " 313 1496-507 2007 https://www.ncbi.nlm.nih.gov/pubmed/17368443 原著論文 "Phosphorylation of neuronal and endothelial nitric oxide synthase in the kidney with high and low salt diets. " "Mount PF, Fraser SA, Watanabe Y, Lane N, Katsis F, Chen ZP, Kemp BE, Power DA. " "Nephron Physiol." 102 p36-50. 2006 https://www.ncbi.nlm.nih.gov/pubmed/16244499 原著論文 "Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage. " "Osuka K, Watanabe Y, Yamauchi K, Nakazawa A, Usuda N, Tokuda M, Yoshida J. " "Brain Res." 1072 "1-7. " 2006 https://www.ncbi.nlm.nih.gov/pubmed/16413512 原著論文 "Clinical significance of Skp2 expression, alone and combined with Jab1 and p27 in epithelial ovarian tumors. " "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M. " "Oncol Rep. " 15 765-71. 2006 https://www.ncbi.nlm.nih.gov/pubmed/16525656 原著論文 "Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors. " "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M. " "Oncol Rep. " 15 773-8. 2006 https://www.ncbi.nlm.nih.gov/pubmed/16525657 原著論文 "Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. " "Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P. " "Proc Natl Acad Sci U S A. " 102 "1199-204. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/15657149 原著論文 "Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. " "Dong Y, Sui L, Watanabe Y, Yamaguchi F, Hatano N, Tokuda M." "Clin Cancer Res. " 11 259-66. 2005 https://www.ncbi.nlm.nih.gov/pubmed/15671554 原著論文 "Growth inhibitory effect of D-allose on human ovarian carcinoma cells in vitro. " "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Hatano N, Izumori K, Tokuda M. " "Anticancer Res." 25 2639-44. 2005 https://www.ncbi.nlm.nih.gov/pubmed/16080505 原著論文 "The inhibitory effect and possible mechanisms of D-allose on cancer cell proliferation. " "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Hatano N, Tsukamoto I, Izumori K, Tokuda M. " " Int J Oncol. " 27 907-12. 2005 https://www.ncbi.nlm.nih.gov/pubmed/16142305 原著論文 "Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells. " "Song T, Hatano N, Kume K, Sugimoto K, Yamaguchi F, Tokuda M, Watanabe Y. " "FEBS Lett. " 579 5658-62. 2005 https://www.ncbi.nlm.nih.gov/pubmed/16214135 原著論文 "Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells. " "Takata MK, Yamaguchi F, Nakanose K, Watanabe Y, Hatano N, Tsukamoto I, Nagata M, Izumori K, Tokuda M." " J Biosci Bioeng. " 100 511-6. 2005 https://www.ncbi.nlm.nih.gov/pubmed/16384789 原著論文 "Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei. " "Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA. " "Neurochem Int." 44 617-25. 2004 https://www.ncbi.nlm.nih.gov/pubmed/15016477 原著論文 "Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. " "Takenouchi Y, Oo ML, Senga T, Watanabe Y, Machida K, Miyazaki K, Nimura Y, Hamaguchi M. " "Oncol Rep. " 11 1059-62. 2004 https://www.ncbi.nlm.nih.gov/pubmed/15069547 原著論文 "Phosphohippolin expression in the rat central nervous system. " "Kadowaki K, Sugimoto K, Yamaguchi F, Song T, Watanabe Y, Singh K, Tokuda M. " "Brain Res Mol Brain Res." 125 105-12. 2004 https://www.ncbi.nlm.nih.gov/pubmed/15193427 原著論文 "Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. " "Song T, Hatano N, Horii M, Tokumitsu H, Yamaguchi F, Tokuda M, Watanabe Y. " "FEBS Lett." 570 133-7. 2004 https://www.ncbi.nlm.nih.gov/pubmed/15251453 原著論文 "Modification of endothelial NO synthase through protein phosphorylation after forebrain cerebral ischemia/reperfusion. " "Osuka K, Watanabe Y, Usuda N, Nakazawa A, Tokuda M, Yoshida J. " Stroke 35 2582-6. 2004 https://www.ncbi.nlm.nih.gov/pubmed/15375304 原著論文 "S-phase kinase-associated protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " "Oncol Rep. " 10 321-5. 2003 https://www.ncbi.nlm.nih.gov/pubmed/12579266 原著論文 "Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. " " Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M. " "Biochem J." "372(Pt 2)" 465-71. 2003 https://www.ncbi.nlm.nih.gov/pubmed/12630910 原著論文 "Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors. " "Mamiya T, Yamada K, Miyamoto Y, König N, Watanabe Y, Noda Y, Nabeshima T. " "Mol Psychiatry." 8 752-65. 2003 https://www.ncbi.nlm.nih.gov/pubmed/12888804 原著論文 "A novel inhibitory effect of D-allose on production of reactive oxygen species from neutrophils. " "Murata A, Sekiya K, Watanabe Y, Yamaguchi F, Hatano N, Izumori K, Tokuda M. " " J Biosci Bioeng" 96 89-91. 2003 https://www.ncbi.nlm.nih.gov/pubmed/16233490 原著論文 "Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " " Cancer Lett." 177 13-9. 2002 https://www.ncbi.nlm.nih.gov/pubmed/11809526 原著論文 "Aberrant expression of cyclin A in laryngeal squamous cell carcinoma. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " "Anticancer Res. " 22(1A) 83-9. 2002 https://www.ncbi.nlm.nih.gov/pubmed/12017338 原著論文 "Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. " "Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M. " "Int J Oncol. " 21 315-20. 2002 https://www.ncbi.nlm.nih.gov/pubmed/12118327 原著論文 "Survivin expression in laryngeal squamous cell carcinomas and its prognostic implications. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " " Anticancer Res. " 22 2377-83. 2002 https://www.ncbi.nlm.nih.gov/pubmed/12174930 原著論文 "Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia. " "Osuka K, Watanabe Y, Usuda N, Nakazawa A, Fukunaga K, Miyamoto E, Takayasu M, Tokuda M, Yoshida J. " "J Cereb Blood Flow Metab." 22 1098-106. 2002 https://www.ncbi.nlm.nih.gov/pubmed/12218415 原著論文 "Expression of p57kip2 and its clinical relevance in epithelial ovarian tumors. " "Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M. " "Anticancer Res. " 22(6A) 3191-6. 2002 https://www.ncbi.nlm.nih.gov/pubmed/12530064 原著論文 "Dephosphorylation of nNOS at Ser(847) by protein phosphatase 2A. " "Komeima K, Watanabe Y. " "FEBS Lett." 497 "65-6. " 2001 https://www.ncbi.nlm.nih.gov/pubmed/11376664 原著論文 "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. " "Komeima K, Hayashi Y, Naito Y, Watanabe Y. " "J Biol Chem." 275 28139-43. 2000 https://www.ncbi.nlm.nih.gov/pubmed/10874031 原著論文 "Regulation of neuronal nitric-oxide synthase by calmodulin kinases." "Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y." "J Biol Chem. " 274 20597-20602. 1999 10.1074/jbc.274.29.20597 http://www.jbc.org/content/274/29/20597.long 原著論文 "Multi-modality assessment of nitric oxide synthase inhibition in focal cerebral ischemia" "Koketsu N., Suzuki Y., Watanabe Y., Takayasu M., Kano T., Dogan A., Shibuya M., Saito K., and Yoshida J." "J. Neurovascular Disease" 3 243-252 1998 原著論文 "Cloning and expression of a cDNA encoding a new neurocalcin isoform (neurocalcin alpha) from bovine brain. " "Kato M, Watanabe Y, Iino S, Takaoka Y, Kobayashi S, Haga T, Hidaka H. " " Biochem J. " "331 ( Pt 3)" :871-6. 1998 https://www.ncbi.nlm.nih.gov/pubmed/9560316 原著論文 "Inducible cyclooxygenase expression in canine basilar artery after experimental subarachnoid hemorrhage. " "Osuka K, Suzuki Y, Watanabe Y, Takayasu M, Yoshida J. " "Stroke. " 29 1219-22. 1998 https://www.ncbi.nlm.nih.gov/pubmed/9626297 原著論文 "Inter-isoformal regulation of nitric oxide synthase through heteromeric dimerization. " "Watanabe Y, Nishio M, Hamaji S, Hidaka H. " " Biochim Biophys Acta. " 1388 199-208. 1998 https://www.ncbi.nlm.nih.gov/pubmed/9774731 原著論文 "HMN-1180, a small molecule inhibitor of neuronal nitric oxide synthase. " "Nishio M, Watanabe Y, Hidaka H. " "J Pharmacol Exp Ther. " 287 1063-7. 1998 https://www.ncbi.nlm.nih.gov/pubmed/9864293 原著論文 "Neuronal nitric oxide synthase-membrane phospholipid interactions. " "Watanabe Y, Nishio M, Hamaji S, Hayashi Y, Hu Y, Hidaka H." "Arch Biochem Biophys." 358 68-73. 1998 https://www.ncbi.nlm.nih.gov/pubmed/9750166 総説 "Analysis of structure-function and activation mechanism of NOS." "Yasuo Watanabe" "Folia Pharmacol. Jpn.（日本薬理学雑誌(）" 110 69-75 1997 原著論文 "Identification of a specific amino acid cluster in the calmodulin-binding domain of the neuronal nitric oxide synthase. " "Watanabe Y, Hu Y, Hidaka H. " " FEBS Lett. " 403 75-8. 1997 https://www.ncbi.nlm.nih.gov/pubmed/9038363 原著論文 "Vasodilator effects on canine basilar artery induced by intracisternal interleukin-1 beta. " "Osuka K, Suzuki Y, Watanabe Y, Dogan A, Takayasu M, Shibuya M, Yoshida J. " "J Cereb Blood Flow Metab. " 17 1337-45. 1997 https://www.ncbi.nlm.nih.gov/pubmed/9397033 原著論文 "Isoform-specific activation and structural diversity of calmodulin kinase I. " "Naito Y, Watanabe Y, Yokokura H, Sugita R, Nishio M, Hidaka H. " "J Biol Chem." 272 32704-8. 1997 https://www.ncbi.nlm.nih.gov/pubmed/9405489 原著論文 "Activation of calcineurin A subunit phosphatase activity by its calcium-binding B subunit. " "Watanabe Y, Perrino BA, Soderling TR." " Biochemistry. " 35 562-6. 1996 https://www.ncbi.nlm.nih.gov/pubmed/8555228 原著論文 "Neuronal nitric oxide synthase specific autophosphorylation in baculovirus/Sf9 insect cell system. " "Watanabe Y, Terashima K, Hidaka H. " "Biochem Biophys Res Commun. " 219 638-43. 1996 https://www.ncbi.nlm.nih.gov/pubmed/8605040 原著論文 "A new and potent calmodulin antagonist, HF-2035, which inhibits vascular relaxation induced by nitric oxide synthase. " "Win NH, Ishikawa T, Saito N, Kato M, Yokokura H, Watanabe Y, Iida Y, Hidaka H. " "Eur J Pharmacol. " 299 119-26. 1996 https://www.ncbi.nlm.nih.gov/pubmed/8901014 原著論文 "Isoform-specific intracellular vesicle formation by recombinant annexin XI-A in Sf9 cells. " "Sudo T, Mamiya N, Goto M, Watanabe Y, Hidaka H. " "Biochem Biophys Res Commun. " 223 706-11. 1996 https://www.ncbi.nlm.nih.gov/pubmed/8687461 "原著論文 " "Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit." "Watanabe Y, Perrino BA, Chang BH, Soderling TR." "J Biol Chem." 270 456-60. 1995 "10.1074/jbc.270.1.456 " http://www.jbc.org/content/270/1/456.long 原著論文 "Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene. " "Watanabe Y, Usada N, Minami H, Morita T, Tsugane S, Ishikawa R, Kohama K, Tomida Y, Hidaka H. " "FEBS Lett. " 324 51-5. 1993 https://www.ncbi.nlm.nih.gov/pubmed/8504859 原著論文 "Relaxant effects of various xanthine derivatives. Relationship to cyclic nucleotide phosphodiesterase inhibition. " "Takagi K, Ogawa K, Tanaka H, Satake T, Watanabe Y, Chijiwa T, Hidaka H. " "Adv Second Messenger Phosphoprotein Res" 25 "353-62. " 1992 https://www.ncbi.nlm.nih.gov/pubmed/1313267 原著論文 "Isolation and characterization of a calcium-binding protein derived from mRNA termed p9Ka, pEL-98, 18A2, or 42A by the newly synthesized vasorelaxant W-66 affinity chromatography. " "Watanabe Y, Kobayashi R, Ishikawa T, Hidaka H. " "Arch Biochem Biophys. " 292 563-9. 1992 https://www.ncbi.nlm.nih.gov/pubmed/1731618 原著論文 "Specific binding of CAP-50 to calcyclin. " "Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H. " "FEBS Lett. " 305 217-9. 1992 https://www.ncbi.nlm.nih.gov/pubmed/1299619 原著論文 "Calvasculin, an encoded protein from mRNA termed pEL-98, 18A2, 42A, or p9Ka, is secreted by smooth muscle cells in culture and exhibits Ca(2+)-dependent binding to 36-kDa microfibril-associated glycoprotein. " "Watanabe Y, Usuda N, Tsugane S, Kobayashi R, Hidaka H." " J Biol Chem. " 267 17136-40. 1992 https://www.ncbi.nlm.nih.gov/pubmed/1512251 総説 "[Trend in the development of new inhibitors of cyclic nucleotide metabolism and their clinical application]. " "Hidaka H, Hagiwara M, Watanabe Y. " "Nihon Rinsho." 49 "961-7. " 1991 https://www.ncbi.nlm.nih.gov/pubmed/1649350