種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Activated tyrosine kinase c-Src-responsive artificial gene carrier: in vitro and in vivo evaluation" "Terada K, Asai D, Kang J.H., Mori T, Katayama Y." ChemistrySelect 9 e202303331 2024 総説 "Bisphenol A (BPA) and cardiovascular or cardiometabolic diseases" "Kang JH, Asai D, Toita R." "J. Xenobiot." 13 775-810 2023 原著論文 "Synthesis, odour characteristics, and antimicrobial activity of optically active (Z)-7-decen-4-olide and its derivatives" "Shimotori Y, Ogawa N, Mamada S, Miyakoshi T, Masuda H, Kitago S, Shima T, Asai D, Kanamoto T" "J. Oleo Sci." 72 1037-1048 2023 原著論文 "Synthesis and cytotoxic mechanism of sulfated alkyl oligosaccharides having potent anti-HIV activity" "Mingxue B, Asai D, Koshikawa T, Takemura H, Miyazaki K, Yoshida T." "J. Fiber Sci. Technol." 79 101-111 2023 原著論文 "Electrostatic interaction between sulfated polysaccharides and oligopeptides from viral envelope glycoproteins using surface plasmon resonance" "Battulga T, Dagaerbieke A, Bai C, Asai D, Koshikawa T, Takemura H, Miyazaki K, Yoshida T." "Carbohydr. Res." 528 108815 2023 原著論文 "Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5" "Kajikawa M, Hata H, Ishimura M, Imaizumi N, Kimura M, Miyano K, Ose T, Asai D, Ishido S, Kanamoto T" "Biochem J" 479(20) 2261-2278 2022 原著論文 "A model of transcriptional activation of DNA by loosening of chromatin structure" "Sato YT, Asai D, Terada K, Kang JH, Mori T, Niidome T, Nakashima H, Katayama Y" "Chem Lett" 51(12) 1109-1112 2022 総説 リグニンスルホン酸塩の瞬間的ウイルス不活化作用 "坂上宏, 福地邦彦, 浅井大輔, 金本大成, 越川拓郎, 竹村弘, 猪俣恵, 相見光, 吉川裕治" "New Food Industry" 64(2) 106-110 2022 原著論文 古くても今なお有用な[γ-32P]ATP：32Pを用いる酵素活性測定法によるタンパク質リン酸化酵素に対するペプチド性基質の開発 "浅井大輔, 姜貞勲, 片山佳樹" 分析化学 71(3) 179-185 2022 原著論文 "Re-evaluation of chemotherapeutic potential of pyoktanin blue" "Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S" "Medicines (Basel)" 8(7) e33 2021 原著論文 "Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation" "Asai D, Inoue N, Sugiyama M, Fujita T, Matsuyama Y, Liu X, Matsushima A, Nose T, Costa T, Shimohigashi Y" "Bioorg Med Chem" 51 116498-116498 2021 原著論文 "Lignosulfonate rapidly inactivates human immunodeficiency and herpes simplex viruses" "Fukuchi K, Koshikawa T, Asai D, Inomata M, Sakagami H, Takemura H, Kanamoto T, Aimi H, Kikkawa Y" "Medicines (Basel)" 8(10) e56 2021 原著論文 "Evaluation of a new point-of-care quantitative reverse transcription polymerase chain test for detecting severe acute respiratory syndrome coronavirus 2" "Watanabe Y, Oikawa R, Suzuki T, Funabashi H, Asai D, Hatori Y, Takemura H, Yamamoto H, Itoh F" "J Clin Lab Anal" 35 e23992 2021 総説 クマ笹アルカリ抽出液(ササヘルス®)は，瞬間的にウイルスを不活化する 坂上宏，福地邦彦，浅井大輔，寺久保繁美，竹村弘，堀内美咲，藤澤知弘，勝呂まどか，戸枝一喜，安井利一，大泉浩史，大泉高明 "New Food Industry" 62(11) 785-790 2020 原著論文 "Quantification of the ability of natural products to prevent herpes virus infection" "Fukuchi K, Sakagami H, Sugita Y, Takao K, Asai D, Terakubo S, Takemura H, Ohno H, Horiuchi M, Suguro M, Fujisawa T, Toeda K, Oizumi H, Yasui T, Oizumi T." Medicines(Basel) 7 e64 2020 原著論文 漢方製剤の抗腫瘍活性，抗ウイルス活性，神経保護作用の定量化 史海霞，福地邦彦，浅井大輔，寺久保繁美，竹村弘，坂上宏 "New Food Industry" 62(8) 599-607 2020 総説 "Design of substrates and inhibitors of G protein-coupled receptor kinase 2 (GRK2) based on its phosphorylation reaction" "Kang JH, Toita R, Kawano T, Murata M, Asai D." "Amino Acids" 52(6-7) 863-870 2020 原著論文 "Blood retention and antigenicity of polycarboxybetaine-modified liposomes" "Ryujin T, Shimizu T, Miyahara R, Asai D, Shimazui R, Yoshikawa T, Kishimura A, Mori T, Ishida T, Katayama Y." "Int J Pharm" 586 119521 2020 原著論文 "Elucidation of anti-HIV mechanism of sulfated cellobiose–polylysine dendrimers" "Weiyue S, Ying L, Kanamoto T, Asai D, Takemura H, Nakashima H, Miyazaki K, Yoshida T." "Carbohydr Res" 495 108084 2020 原著論文 "Role of a long-chain alkyl group in sulfated alkyl oligosaccharides with high anti-HIV activity revealed by SPR and DLS" "Mingxue B, Chaolumen B, Asai D, Takemura H, Miyazaki K, Yoshida T." "Carbohydr Polym" 245 116518 2020 原著論文 "Effect of fetal bovine serum concentration on lysophosphatidylcholine-mediated proliferation and apoptosis of human aortic smooth muscle cells" "Asai D, Kawano T, Murata M, Nakashima H, Toita R, Kang JH." "J Oleo Sci" 69(3) 255-260 2020 原著論文 "Synthesis and anti-HIV activity of sulfated oligosaccharide-branched β-CD" "Mingxue B, Chaolumen B, Asai D, Miyazaki K, Yoshida T. " "J Fiber Sci Technol" 76(1) 63-71 2020 原著論文 "Injectable polypeptide hydrogel depot system for assessment of the immune-response-inducing efficacy of sustained antigen release alone" "Asai D, Fukuda T, Morokuma K, Funamoto D, Yamaguchi Y, Mori T, Katayama Y, Shibayama K, Nakashima H." "Macromol Biosci" 19(10) e1900167 2019 原著論文 "Suppression of lysophosphatidylcholine-induced human aortic smooth muscle cell calcification by protein kinase A inhibition" "Toita R, Asai D, Otani K, Kawano T, Murata M, Kang JH." Lipids 54(8) 465-470 2019 原著論文 "A high‑affinity peptide substrate for G protein‑coupled receptor kinase 2 (GRK2)" "Asai D, Murata M, Toita R, Kawano T, Nakashima H, Kang JH" "Amino Acids" 51(6) 973-976 2019 総説 "Pathogenic viruses commonly present in the oral cavity and relevant antiviral compounds derived from natural products" "Asai D, Nakashima H." Medicines(Basel) 5(4) e120 2019 原著論文 "A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells" "Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y." MedChemComm 9(5) 783-788 2018 原著論文 "In situ depot formation of anti-HIV fusion-inhibitor peptide in recombinant protein polymer hydrogel" "Asai D, Kanamoto T, Takenaga M, Nakashima H." "Acta Biomater" 64 116-125 2017 原著論文 "Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2)" "Asai D, Murata M, Toita R, Kawano T, Nakashima H, Kang JH." "Amino Acids" 48(12) 2875-2880 2016 原著論文 "Reversal of efflux of an anticancer drug in human drug-resistant breast cancer cells by inhibition of protein kinase Cα (PKCα) activity" "Kim CW, Asai D, Kang JH, Kishimura A, Mori T, Katayama Y." "Tumour Biol" 37(2) 1901-1908 2016 原著論文 "Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor" "Mukerji R, Schaal J, Li X, Bhattacharyya J, Asai D, Zalutsky MR, Chilkoti A, Liu W." Biomaterials 79 79-87 2016 原著論文 "Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery" "Murata M, Piao JS, Narahara S, Kawano T, Hamano N, Kang JH, Asai D, Ugawa R, Hashizume M." "Protein Expr Purif" 110 52-56 2015 原著論文 "Monitoring of phosphorylated peptides by radioactive assay and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry" "Kang JH, Asai D, Toita R, Kawano T, Murata M." "Amino Acids" 47(11) 2377-2383 2015 原著論文 "Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor" "Takenaga M, Yamamoto Y, Takeuchi T, Ohta Y, Tokura Y, Hamaguchi A, Asai D, Nakashima H, Oishi S, Fujii N." "Biochem Biophys Res Commun" 463(3) 222-228 2015 原著論文 "Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation " "Funamoto D, Asai D, Kim CW, Nakamura Y, Lee EK, Nobori T, Niidome T, Mori T, Katayama Y" "Chem Lett" 44(4) 474-476 2015 原著論文 "Antibody internalization into living cell via crosslinker-mediated endocytosis" "Funamoto D, Asai D, Sato K, Yamaguchi Y, Kim CW, Sato H, Nakhaei E, Matsumoto S, Yoshikawa T, Sasaki K, Yamamoto T, Kishimura A, Mori T, Katayama Y." "Chem Lett" 44(4) 468-470 2015 原著論文 "Reduction of inorganic phosphate-induced human smooth muscle cells calcification by inhibition of protein kinase A and p38 mitogen-activated protein kinase" "Kang JH, Toita R, Asai D, Yamaoka T, Murata M." "Heart Vessels" 29(5) 718-722 2014 原著論文 "Liver cell-specific peptides derived from the PreS1 domain of human hepatitis B virus" "Kang JH, Toita R, Asai D, Yamaoka T, Murata M." "J Virol Methods" 201 20-23 2014 原著論文 "Peptide substrates for G protein-coupled receptor kinase 2" "Asai D, Toita R, Murata M, Katayama Y, Nakashima H, Kang JH." "FEBS Lett" 588(13) 2129-2132 2014 原著論文 "Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptide in situ" "Liu W, McDaniel JR, Li X, Asai D, Garcia Quiroz F, Schaal J, Park JS, Zalutsky MR, Chilkoti A." "Cancer Res" 72(22) 5956-5965 2012 原著論文 "Rheological properties of cysteine-containing elastin-like polypeptides solution and hydrogels" "Xu D, Asai D, Chilkoti A, Craig SL." Biomacromolecules 13(8) 2315-2321 2012 原著論文 "Protein polymer hydrogels by in situ, rapid and reversible self-gelation" "Asai D, Xu D, Liu W, Garcia Quiroz F, Callahan DJ, Zalutsky MR, Craig SL, Chilkoti A." Biomaterials 33(21) 5451-5458 2012 原著論文 "Correlation between phosphorylation ratios by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and radioactivities by radioactive assay" "Tsuchiya A, Asai D, Kang JH, Mori T, Niidome T, Katayama Y." "Anal Biochem" 421(2) 773-775 2012 原著論文 "Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation" "Tsuchiya A, Kang JH, Asai D, Mori T, Niidome T, Katayama Y." "J Control Release" 155(1) 40-46 2011 原著論文 "Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2)" "Kang JH, Asai D, Tsuchiya A, Mori T, Niidome T, Katayama Y." "PLoS One" 6(7) e22699 2011 原著論文 "Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule" "Kang JH, Oishi J, Kim JH, Ijuin M, Toita R, Jun B, Asai D, Mori T, Niidome T, Tanizawa K, Kuroda S, Katayama Y." Nanomedicine 6(4) 583-589 2010 原著論文 "Tumor therapy by gene regulation system responding to cellular signal" "Tomiyama T, Toita R, Kang JH, Asai D, Shiosaki S, Mori T, Niidome T, Katayama Y." "J Control Release" 148(1) 101-105 2010 総説 D-RECS：疾患細胞特異的な遺伝子発現制御技術の開発 浅井大輔 "Drug Delivery System" 25(4) 426-427 2010 総説 "Progress in current non-viral carriers for gene delivery" "Shoji-Moskowitz Y, Asai D, Kodama K, Katayama Y, Nakashima H." "Front Med Chem" 5(1) 81-97 2010 原著論文 "Specific transgene expression in HIV-infected cells using protease-cleavable transcription regulator " "Asai D, Kuramoto M, Shoji Y, Kang JH, Kodama KB, Kawamura K, Mori T, Miyoshi H, Niidome T, Nakashima H, Katayama Y." "J Control Release" 141(1) 52-61 2010 原著論文 "Molecular mechanism of caspase-3-induced gene expression of polyplexes formed from polycations grafted with cationic substrate peptides" "Kawamura K, Kuramoto M, Mori T, Toita R, Oishi J, Sato Y, Kang JH, Asai D, Niidome T, Katayama Y." "J Biomater Sci Polym Ed" 20(7-8) 967-980 2009 原著論文 "Cellular signal-specific peptide substrate is essential for the gene delivery system responding to cellular signals" "Kang JH, Toita R, Tomiyama T, Oishi J, Asai D, Mori T, Niidome T, Katayama Y." "Bioorg Med Chem Lett" 19(21) 6082-6086 2009 原著論文 "Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers" "Kang JH, Asai D, Toita R, Kitazaki H, Katayama Y." Carcinogenesis 30(11) 1927-1931 2009 原著論文 "Regulation of transgene expression in tumor cells by exploiting endogenous intracellular signals " "Asai D, Kang JH, Toita R, Tsuchiya A, Niidome T, Nakashima H, Katayama Y." "Nanoscale Res Lett" 4(3) 229-233 2009 原著論文 "Inflammatory cell-specific transgene expression system responding to Ikappa-beta kinase beta activation" "Asai D, Tsuchiya A, Kang JH, Kawamura K, Oishi J, Mori T, Niidome T, Shoji Y, Nakashima H, Katayama Y." "J Gene Med" 11(7) 624-632 2009 原著論文 "Correlation between phosphorylation ratios by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis and enzyme kinetics" "Kang JH, Kuramoto M, Tsuchiya A, Toita R, Asai D, Sato YT, Mori T, Niidome T, Katayama Y." "Eur J Mass Spectrom" 14(4) 261-265 2008 原著論文 "Role of plasma as activator and cofactor in phosphorylation catalyzed by protein kinase C" "Kang JH, Asai D, Oishi J, Kawamura K, Toita R, Jiang Y, Mori T, Niidome T, Katayama Y." "Cell Biochem Funct" 26(1) 70-75 2008 原著論文 自殺遺伝子治療を目指した疾患細胞選択的な遺伝子発現制御法の開発 浅井大輔，中島秀喜 日本化学療法学会雑誌 56 538-542 2008 原著論文 "Drug delivery system based on responses to an HIV infectious signal" "Asai D, Kodama KB, Shoji Y, Nakashima H, Kawamura K, Oishi J, Kuramoto M, Niidome T, Katayama Y." "Med Chem" 4(4) 386-391 2008 原著論文 "A short peptide is a protein kinase C (PKC) alpha-specific substrate" "Kang JH, Asai D, Yamada S, Toita R, Oishi J, Mori T, Niidome T, Katayama Y." Proteomics 8(10) 2006-2011 2008 原著論文 "Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells" "Kang JH, Asai D, Kim JH, Mori T, Toita R, Tomiyama T, Asami Y, Oishi J, Sato YT, Niidome T, Jun B, Nakashima H, Katayama Y." "J Am Chem Soc" 130(45) 14906-14907 2008 原著論文 "Direct measure of fluorescence intensity for efficient receptor-binding assay: Conjugates of ethinylcarboxyestradiol and 5(and 6)-carboxyfluorescein via α,ω-diaminoalkanes as a tracer for etrogen receptor" "Asai D, Tokunaga T, Kondo K, Kawaguchi T, Takayanagi S, Shinmyozu T, Nakai M, Yakabe Y, Shimohigashi Y." "J Biochem" 143(6) 781-792 2008 総説 酵素の基質ペプチドを用いて人工的に遺伝子発現を制御する 浅井大輔 "Peptide Newsletter Japan" 67 8-11 2008 原著論文 "Direct, real-time, simultaneous monitoring of intravitreal nitric oxide and oxygen in endotoxin-induced uveitis in rabbits" "Yomura Y, Shoji Y, Asai D, Murakami E, Ueno S, Nakashima H." "Life Sci" 80(16) 1449-1457 2007 総説 "Bisphenol A in the aquatic environment and its endocrine-disruptive effects on aquatic organisms" "Kang JH, Asai D, Katayama Y." "Crit Rev Toxicol" 37(7) 607-625 2007 総説 感染細胞内におけるシグナル応答型のDDS 東海林洋子，児玉耕太，浅井大輔，片山佳樹，中島秀喜 "Drug Delivery System" 21(5) 505-515 2006 原著論文 "Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina" "Matsushima A, Yokotani S, Liu X, Sumida K, Honda T, Sato S, Kaneki A, Takeda Y, Chuman Y, Ozaki M, Asai D, Nose T, Onoue H, Ito Y, Tominaga Y, Shimohigashi Y, Shimohigashi M." "Lett Pept Sci" 10(5-6) 419-430 2003 原著論文 "Synthesis of a complete set of L-difluorophenylalanines, L-(F-2)Phe, as molecular explorers for the CH/-pi interaction between peptide ligand and receptor" "Fujita T, Nose T, Matsushima A, Okada K, Asai D, Yamauchi Y, Shirasu N, Honda T, Shigehiro D, Shimohigashi Y." "Tetrahedron Lett" 41(6) 923-927 2000 総説 受容体分子を用いた競合結合試験による評価 浅井大輔，下東康幸 日本臨床 58 112-116 2000 原著論文 "Structural essentials of xenoestrogen dialkyl phthalates to bind to the estrogen receptors" "Asai D, Tahara Y, Nakai M, Yakabe Y, Takatsuki M, Nose T, Shinmyozu T, Shimohigashi Y." "Toxicol Lett" 118(1-2) 1-8 2000 原著論文 "Structural requirements of para-alkylphenols to bind to estrogen receptor" "Tabira Y, Nakai M, Asai D, Yakabe Y, Tahara Y, Shinmyozu T, Noguchi M, Takatsuki M, Shimohigashi Y." "Eur J Biochem" 262(1) 240-245 1999 原著論文 "Binding characteristics of dialkyl phthalates for the estrogen receptor" "Nakai M, Tabira Y, Asai D, Yakabe Y, Shimyozu T, Noguchi M, Takatsuki M, Shimohigashi Y." "Biochem Biophys Res Commun" 254(2) 311-314 1999