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Biol." 27 334-349 2020 10.1016/j.chembiol.2020.01.006 原著論文 "Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoylglycerol and its congeners in human myeloid leukocytes" "Turcotte C, Archambault AS, Dumais É, Martin C, Blanchet MR, Bissonnette E, Ohashi N, Yamamoto K, Itoh T, Laviolette M, Veilleux A, Boulet LP, Marzo VD, Flamand N." "FASEB J." 34 4253-4265 2020 10.1096/fj.201902916R 原著論文 "Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone." "Kubo M, Yamamoto K, Itoh T." "Bioorg. Med. Chem." 27 285–304 2019 10.1016/j.bmc.2018.11.045. 原著論文 "Construction of a series of intermediates in the β-oxidation pathway from THA to EPA via DHA in free acid form." "Kanamori S, Ishida H, Yamamoto K, Itoh T." "Bioorg. Med. Chem." 26 4390-4401. 2018 10.1016/j.bmc.2018.07.004. 原著論文 "Metabolic enhancement of 2,3´,4,4´,5-pentachlorobiphenyl (CB118) using cytochrome P450 monooxygenase isolated from soil bacterium under the presence of perfluorocarboxylic acids (PFCAs) and the structural basis of its metabolism." "Goto E, Haga Y, Kubo M, Itoh T, Kasai C, Shoji O, Yamamoto K, Matsumura C, Nakano T, Inui H." Chemosphere 210 376-383. 2018 10.1016/j.chemosphere.2018.07.026. 原著論文 "Identification of the histidine residue in vitamin D receptor that covalently binds to electrophilic ligands." "Yoshizawa M, Itoh T, Hori T, Kato A, Anami Y, Yoshimoto N, Yamamoto K." "J. Med. Chem." 61 6339-6349. 2018 10.1021/acs.jmedchem.8b00774. 原著論文 "Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group." "Itoh T, Yoshimoto N, Hirano Y, Yamamoto K." "Bioorg. Med. Chem. 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"Ohura A, Itoh T, Ishida H, Saito A, Yamamoto K." "Asian J. Org. Chem." 6 673–676. 2017 10.1002/ajoc.201700074 原著論文 "SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity." "Egawa D, Itoh T, Kato A, Kataoka S, Anami Y, Yamamoto K." "Bioorg. Med. Chem." 25 568–574. 2017 10.1016/j.bmc.2016.11.020 原著論文 "17-oxoDHA is a PPARα/γ dual covalent modifier and agonist." "Egawa D, Itoh T, Akiyama Y, Saito T, Yamamoto K" "ACS Chem. Biol." 11 2447−2455. 2016 原著論文 "Helix12-stabilization antagonist of vitamin D receptor." "Kato A, Anami Y, Egawa D, Itoh T, Yamamoto K" "Bioconjugate Chem." 27 1750-1761 2016 総説 ポリフェノールとCYP1のドッキングスタディ 伊藤俊将 ポリフェノール学会雑誌 5 43-46 2016 原著論文 "Gram scale synthesis of specialized pro-resolving mediator 17(S)-HDHA using lipoxygenase enhanced by water-soluble reducing agent TCEP." "Itoh T, Saito T, Yamamoto Y, Ishida H, Yamamoto K." "Bioorg Med Chem. 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Chem." 23 7274–7281 2015 10.1016/j.bmc.2015.10.026 http://www.sciencedirect.com/science/article/pii/S0968089615301048 原著論文 "Chemical Synthesis of a Very Long Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid." "Yamamoto Y, Itoh T, Yamamoto K." "Nutr Sci Vitaminol" 61 222–227 2015 10.3177/jnsv.61.222 原著論文 "Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting" "Itoh T, Fairall L, Muskett FW, Milano CP, Watoson PJ, Arnaudo N, Saleh A, Millard CJ, El-Mezgueldi M, Martino F, Schwabe JWR." "Nucleic Acids Res" 43 2033-2044 2015 10.1093/nar/gkv068 http://nar.oxfordjournals.org/content/early/2015/02/03/nar.gkv068 原著論文 "Characterization of covalent bond formation between PPARγ and oxo-fatty acids." "Egawa D, Itoh T, Yamamoto K." "Bioconjugate Chem." 26 690-698 2015 原著論文 "A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: Active vitamin D analogues with 22R-alkyl group." "Anami Y, Itoh T, Egawa D, Yoshimoto N, Yamamoto K" "J. Med. Chem." 57 4351-4367 2014 総説 "Development of vitamin D analogues that modulate the pocket structure of vitamin D receptor. " "Yamamoto K,* Anami Y, Itoh T. " "Curr. Top. Med. Chem." 14 2378-2387 2014 総説 "Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. " "Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T. " "Int. J. Mol. Sci." 15 14044-14057 2014 総説 "Development of vitamin D analogs modulating the pocket structure of vitamin D receptor." "Yamamoto K, Anami Y, Itoh T." "Curr. Top. Med. 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"Itoh T, Tomiyasu A, Yamamoto K" Lipids 46 391-397 2011 10.1007/s11745-011-3541-5. 原著論文 "Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3’,4,4’,5-pentachlorobiphenyl." "Yamazaki K, Suzuki M, Itoh T., Yamamoto K, Kanemitsu M, Matsumura C, Nakano T, Sakaki T, Fukami Y, Imaishi H, Inui H" "J. Biochem." 149 487-494 2011 10.1093/jb/mvr009. 原著論文 "Selective inhibition of methoxyflavonoids on human CYP1B1 activity." "Takemura H, Itoh T, Yamamoto K, Sakakibara H, Shimoi K" "Bioorg. Med. Chem." 18 6310-6315 2010 10.1016/j.bmc.2010.07.020. 原著論文 "A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol." "Itoh T, Takemura H, Shimoi K, Yamamoto K" "J. Chem. Inf. Model." 50 1173-1178 2010 http://pubs.acs.org/doi/abs/10.1021/ci1000554 原著論文 "22S-Butyl-1α,24R-dihydroxyvitamin D3: Recovery of vitamin D receptor agonistic activity." "Inaba Y, Nakabayashi M, Itoh T., Yoshimoto N, Ikura T, Ito N, Shimizu M, Yamamoto K" "J. Steroid Biochem. Mol. Biol." 121 146-150 2010 10.1016/j.bmcl.2010.04.031. 原著論文 "Synthesis of oxidized fatty acid derivatives via an iodolactonization reaction." "Itoh T, Yoshimoto N, Yamamoto K" Heterocycles 80 689-695 2010 http://www.heterocycles.jp/library/abstract.php?article=14282 原著論文 "Biomimetic Total Synthesis of (±)-8-Oxoerymelanthine." "Yoshida Y, Mohri K, Isobe K, Itoh T, Yamamoto K" "J. Org. Chem." 74 6010-6015 2009 http://pubs.acs.org/doi/abs/10.1021/jo9008645 原著論文 "Structural basis for the activation of PPARγ by oxidized fatty acids." "Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JWR" "Nat. Struct. Mol. Biol." 15 924-931 2008 http://www.nature.com/nsmb/journal/v15/n9/full/nsmb.1474.html 原著論文 "4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor g agonist alleviates the symptoms of DSS-induced colitis." "Yamamoto K, Ninomiya Y, Iseki M, Nakachi Y, Kanesaki-Yatsuka Y, Yamanoue Y, Itoh T, Nishii Y, Petrovsky Y, Okazaki Y " "Biochem. Biophys. Res. Commun." 367 566–572 2008 10.1016/j.bbrc.2007.12.188. 総説 "Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand. " "Itoh T, Yamamoto K" "Naunyn Schmiedebergs Arch. Pharmacol." 377 541-547 2008 原著論文 "Synthesis of docosahexaenoic acid derivatives designed PPARγ agonists and antidiabetic agents." "Itoh T, Murota I, Yoshikai K, Yamada S, Yamamoto K" "Bioorg. Med. Chem." 14 98–108 2006 10.1016/j.bmc.2005.07.074 原著論文 "Identification of putative metabolites of docosahexaenoic acid as potent PPARg agonists and antidiabetic agents." "Yamamoto K,* Itoh T, Abe D, Shimizu M, Kanda T, Koyama T, Nishikawa M, Tamai T, Ooizumie H and Yamada S*" "Bioorg. Med. Chem. 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