種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Mutations in homocysteine metabolism genes increase N-homocysteinylation and keratin damage in mice." "Borowczyk K, Wróblewski J, Maria Suliburska J, Akahoshi N, Ishii I, Jakubowski H." "Int J Genomics" 2018 7570850 2018 10.1155/2018/7570850 原著論文 "2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice." "Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I" "FEBS Open Bio" 8 1524-1543 2018 10.1002/2211-5463.12497 原著論文 "Cystathionine gamma-lyase-produced hydrogen sulfide controls endothelial NO bioavailability and blood pressure." "Szijarto IA, Marko L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I and Gollasch M" Hypertension 71 1210-1217 2018 10.1161/hypertensionaha.117.10562 原著論文 "Structural and functional insights into S-thiolation of human serum albumins." "Nakashima, F. Shibata, T. Kamiya, K. Yoshitake, J. Kikuchi, R. Matsushita, T. Ishii, I. Gimenez-Bastida, J. A. Schneider, C. Uchida, K." "Sci Rep" 8 932 2018 10.1038/s41598-018-19610-9 原著論文 "Hydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammation." "Castelblanco, M. Lugrin, J. Ehirchiou, D. Nasi, S. Ishii, I. So, A. Martinon, F. Busso, N." "J Biol Chem" 293 2546-2557 2018 10.1074/jbc.M117.806869 原著論文 "Rapid 2D DIGE proteomic analysis of mouse liver." "Kamata S, Ishii I" "Methods Mol Biol" 1664 153-166 2018 10.1007/978-1-4939-7268-5_13 原著論文 "The Capture of cadmium by reactive polysulfides attenuates cadmium-induced adaptive responses and hepatotoxicity." "Akiyama, M. Shinkai, Y. Unoki, T. Shim, I. Ishii, I. Kumagai, Y." "Chem Res Toxicol" 30 2209-2217 2017 10.1021/acs.chemrestox.7b00278 原著論文 "Hydrogen sulfide-producing cystathionine gamma-lyase is critical in the progression of kidney fibrosis." "Han SJ, Noh MR, Jung JM, Ishii I, Yoo J, Kim JI, Park KM." "Free Radic Biol Med" 112 423-432 2017 10.1016/j.freeradbiomed.2017.08.017 原著論文 "Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion." "Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K." "Nucleic Acids Res" 45 435-445 2017 10.1093/nar/gkw745 原著論文 "Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis." "Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couture DG, Ishii I, Bhatia M" "PLoS One" 11 e0160521 2016 10.1371/journal.pone.0160521 原著論文 "Immobilization of the gas signaling molecule H2S by radioisotopes: detection, quantification, and in vivo imaging." "Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J." "Angew Chem Int Ed Engl" 55 9635-9670 2016 10.1002/anie.201603813 原著論文 "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)." "Klionsky DJ, Ishii I, et al." Autophagy 12 1-222 2016 10.1080/15548627.2015.1100356 原著論文 "Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice." "Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H." Endocrinology 157 1839-1851 2016 10.1210/en.2015-1768 原著論文 "Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation." "Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR." "Chem Sci" 7 3414-3426 2016 10.1039/C5SC04818D 原著論文 "Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury." "Markó L, Szijártó I, Filipovic MR, Kaßmann M, Balogh A, Park J-K, Przybyl L, N’diaye G, Krämer S, Anders J, Ishii I, Müller DN, Gollasch M" "Sci Rep" 8 27517 2016 10.1038/srep27517 原著論文 "Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice." "Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I." "Toxicol Appl Pharmacol" 282 195-206 2015 10.1016/j.taap.2014.11.015 原著論文 "Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia-reperfusion injury." "Shinmura K, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I." "Am J Physiol Heart Circ Physiol" 308 894-903 2015 10.1152/ajpheart.00333.2014 原著論文 "Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions." "Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M." "J Mol Med (Berl)" 93 879-889 2015 10.1007/s00109-015-1271-5 原著論文 "Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress." "Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y." "Chem Res Toxicol" 28 838-847 2015 10.1021/tx500416y 原著論文 "Involvement of reactive persulfides in biological bismethylmercury sulfide formation." "Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y." "Chem Res Toxicol" 28 1301-1306 2015 10.1021/acs.chemrestox.5b00101 原著論文 "Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis." "Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I." "FEBS Open Bio" 5 357-368 2015 10.1016/j.fob.2015.04.012 原著論文 "2D DIGE proteomic analysis highlights delayed postnatal repression of alpha-fetoprotein expression in homocystinuria model mice." "Kamata S, Akahoshi N, Ishii I." "FEBS Open Bio" 5 535-541 2015 10.1016/j.fob.2015.06.008 原著論文 "The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization." "Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE." "Am J Physiol Lung Cell Mol Physiol" 309 710-724 2015 10.1152/ajplung.00134.2015 原著論文 "Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides." "Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y." "Chem Res Toxicol" 28 1796-1802 2015 10.1021/acs.chemrestox.5b00245 原著論文 "Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice." "Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y." "J Toxicol Sci" 40 837-841 2015 10.2131/jts.40.837 原著論文 "Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice." "Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M, Himi T, Kasahara T, Ishii I." "Mol Nutr Food Res" 58 1309-1321 2014 10.1002/mnfr.201300758 原著論文 "Neutral aminoaciduria in cystathionine beta-synthase-deficient mice; an animal model of homocystinuria." "Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I." "Am J Physiol Renal Physiol" 306 1462-1476 2014 10.1152/ajprenal.00623.2013 原著論文 "The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse." "Ang AD, Rivers-Auty J, Hegde A, Ishii I, Bhatia M." "Am J Physiol Gastrointest Liver Physiol" 305 712-721 2013 10.1152/ajpgi.00044.2013 原著論文 "Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes." "Okamoto M, Yamaoka M, Takei M, Ando T, Taniguchi S, Ishii I, Tohya K, Ishizaki T, Niki I, Kimura T." "Biochem Biophys Res Commun" 442 227-233 2013 10.1016/j.bbrc.2013.11.023 総説 "Reconsideration of homocysteinemia." "Ishii I." Seikagaku 85 1067-1071 2013 http://www.jbsoc.or.jp/seika/wp-content/uploads/2014/07/85-12-03.pdf 原著論文 "Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine gamma-lyase in the pancreatic beta-cell." "Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I." "Mol Cell Endocrinol" 350 31-38 2012 10.1016/j.mce.2011.11.016 原著論文 "TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates." "Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I." "Anal Bioanal Chem" 402 1859-1864 2012 10.1007/s00216-011-5647-2 原著論文 "Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3." "Harada Y, Ishii I, Hatake K, Kasahara T." "Cancer Lett" 319 83-88 2012 10.1016/j.canlet.2011.12.034 原著論文 "Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway." "Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, Nagahata Y, Ishikawa M, Hattori K, Takenouchi T, Takahashi T, Ishii I, Matsubara K, Kabe Y, Uchiyama S, Nagata E, Gadalla MM, Snyder SH, Suematsu M." "Proc Natl Acad Sci USA" 109 1293-1298 2012 10.1073/pnas.1119658109 原著論文 "Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria." "Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I." "Free Radic Biol Med" 52 1716-1726 2012 10.1016/j.freeradbiomed.2012.02.033 総説 "Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration." "Ishii I, Harada Y, Kasahara T." "Front Oncol" 2 137 2012 10.3389/fonc.2012.00137 原著論文 "Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria." "Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I." "Anal Bioanal Chem" 400 1853-1863 2011 10.1007/s00216-011-4703-2 原著論文 "Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2." "Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I." "Epilepsy Behav" 22 659-665 2011 10.1016/j.yebeh.2011.09.002