種別	タイトル	著者	誌名	巻号	ページ	出版年	DOI	URL
"[Original Article]"	"Different coactivator recruitment to human PPARα/δ/γ ligand-binding domains by eight PPAR agonists to treat nonalcoholic fatty liver disease"	"Kamata S, Honda A, Kashiwagi N, Shimamura A, Yashiro S, Komori Y, Hosoda A, Akahoshi N, Ishii I"	Biomedicines	12	624	2024	10.3390/biomedicines12030624	
[Review]	"Sphingosine 1-phosphate regulates obesity and glucose homeostasis"	"Kajita K, Ishii I, Mori I, Asano M, Fuwa M, Morita H"	"Int J Mol Sci"	25	932	2024	10.3390/ijms25020932	
"[Original Article]"	"Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial cells"	"Manandhar S, Chambers S, Miller A, Ishii I, Bhatia M"	"Int J Mol Sci"	24	13650	2023	10.3390/ijms241713650	
[Review]	"Current clinical trial status and future prospects of  PPAR-targeted drugs for treating nonalcoholic fatty  liver disease"	"Kamata S, Honda A, Ishii I"	Biomolecules	13	1264	2023	10.3390/biom13081264	
"[Original Paper]"	"Functional and structural insights into the human PPARα/δ/γ targeting preferences of anti-NASH investigational drugs, lanifibranor, seladelpar, and elafibranor"	"Kamata S, Honda A, Ishikawa R, Akahane M, Fujita A, Kaneko C, Miyawaki S, Habu Y, Shiiyama Y, Uchii K, Machida Y, TOyama T, Ishii I"	Antioxidants	12	1523	2023	10.3390/antiox12081523	
"[Original Paper]"	"Synthesis of sulfides and persulfides Is not impeded by disruption of three canonical enzymes in sulfur metabolism"	"Zainol Abidin, Q. H. Ida, T. Morita, M. Matsunaga, T. Nishimura, A. Jung, M. Hassan, N. Takata, T. Ishii, I. Kruger, W. Wang, R. Motohashi, H. Tsutsui, M. Akaike, T."	Antioxidants	12	868	2023	10.3390/antiox12040868	
[Review]	"Amino acids in health and disease: The good, the bad, and the ugly"	"Ishii I, Bhatia M"	"Int J Mol Sci"	24	4931	2023	10.3390/ijms24054931	
"[Original paper]"	"Differential roles of cystathionine gamma-lyase and mercaptopyruvate sulfurtransferase in hapten-induced colitis and contact dermatitis in mice."	"Akahoshi N, Hasegawa R, Yamamoto S, Takemoto R, Yoshizawa T, Kamichatani W, Ishii I."	"Int J Mol Sci"	24(3)	2659	2023	10.3390/ijms24032659	
"[Original paper]"	"Opposing roles of sphingosine 1-phosphate receptors 1 and 2 in fat deposition and glucose tolerance in obese male mice"	"Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H"	Endocrinology	164	1-13	2023	10.1210/endocr/bqad019	
[Review]	"The perspective of PPAR dual/pan agonists as therapeutic drugs against NAFLD"	"Akihiro Honda, Isao Ishii"	YAKUGAKUZASSHI	142	1335–1343	2022	10.1248/yakushi.22-00159-1	https://www.jstage.jst.go.jp/article/yakushi/142/12/142_22-00159-1/_article/-char/en
"[Original Paper]"	"Hydrogen sulfide attenuates lymphedema via the induction of lymphangiogenesis through a PI3K/Akt-dependent mechanism"	"Suzuki J, Shimizu Y, Hayashi T, Che Y, Pu Z, Tsuzuki K, Narita S, Shibata R, Ishii I, Calvert JW, Murohara T"	"J Am Heart Assoc"	11	e026889	2022	10.1161/jaha.122.026889	
"[Original Papaer]"	"Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate."	"Honda, A.; Kamata, S.; Akahane, M.; Machida, Y.; Uchii, K.; Shiiyama, Y.; Habu, Y.; Miyawaki, S.; Kaneko, C.; Oyama, T.; Ishii, I. "	"Int J Mol Sci"	23	4726	2022	10.3390/ijms23094726	
"[Original Papaer]"	"The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione."	"Murae, M., Shimizu, Y., Yamamoto, Y., Kobayashi, A., Houri, M., Inoue, T., Irie, T., Gemba, R., Kondo, Y., Nakano, Y., Miyazaki, S., Yamada, D., Saitoh, A., Ishii, I., Onodera, T., Takahashi, Y., Wakita, T., Fukasawa, M., Noguchi, K."	"Biochem Biophys Res Commun"	597	30–36	2022	10.1016/j.bbrc.2022.01.106	
"[Original Papaer]"	"A high-methionine diet for one-week induces a high accumulation of methionine in the cerebrospinal fluid and confers bipolar disorder-like behavior in mice."	"Ishii, I.; Kamata, S.; Ito, S.; Shimonaga, A.; Koizumi, M.; Tsushima, M.; Miura, A.; Nagata, T.; Tosaka, Y.; Ohtani, H.; Kamichatani, W.; Akahoshi, N."	"Int. J. Mol. Sci."	23	928	2022	10.3390/ijms23020928	
"[Original Paper]"	"The gasotransmitter hydrogen sulfide (H2S) prevents pathologic calcification (PC) in cartilage"	"Nasi S, Ehirchlou D, Bertran J, Castelbianco M, Mitchell J, Ishii I, So A, Busso N"	Antioxidants	10	1433	2021	10.3390/antiox10091433	
[Review]	"PPARalpha–Ligand Binding Modes Revealed by X-ray Crystallography"	"Kamata S, Ishii I"	YAKUGAKUZASSHI	141	1267–1274	2021	10.1248/yakushi.21-00138	https://www.jstage.jst.go.jp/article/yakushi/141/11/141_21-00138/_article/-char/en
[Review]	"Role of hydrogen sulfide producing and metabolizing enzymes: Insights from human genetic diseases and their mouse models."	"Akahoshi N, Ishii I"	"J Jpn Biochem Soc"	93	754–759	2021	10.14952/SEIKAGAKU.2021.930754	
"[Original Paper]"	"Structural basis for anti-non-alcoholic fatty liver disease and diabetic dyslipidemia drug saroglitazar as a PPARalpha/gamma dual agonist"	"Honda A, Kamata S, Satta C, Machida Y, Uchii K, Terasawa K, Nemoto A, Oyama T, Ishii I"	"Biol Pharm Bull"	44	1210–1219	2021	10.1248/bpb.b21-00232	
"[Original Paper]"	"Crystal structures of the human peroxisome proliferator-activated receptor (PPAR) alpha ligand-binding domain in complexes with a series of phenylpropanoic acid derivatives generated by a ligand-exchanging soaking method"	"Oyama T, Kamata S, Ishii I, Miyachi H"	"Biol Pharm Bull"	44	1202–1209	2021	10.1248/bpb.b21-00220	
"[Original Paper]"	"Preparation of human PPARα ligand binding domain–ligand co-crystals for high-resolution X-ray crystallography"	"Kamata S, Oyama T, Ishii I"	"STAR Protocols"	2	100364	2021	10.1016/j.xpro.2021.100364	
"[Original paper]"	"PPARα ligand-binding domain structures with endogenous fatty acids and fibrates"	"Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I"	iScience	23	101727	2020	10.1016/j.isci.2020.101727	
"[Original paper]"	"Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines"	"Kamata S, Hashiyama R, Hana-ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I"	"Toxicol In Vitro"	69	104999	2020	10.1016/j.tiv.2020.104999	
"[Original paper]"	"Homocysteine hypothesis on the impaired peripheral but not central nervous system oxytocin responses in cystathionine γ-lyase-deficient dam mice"	"Akahoshi N, Kamichatani W, Ishii I"	"Biol Pharm Bull"	43	1810–1813	2020	10.1248/bpb.b20-00676	
"[Original Paper]"	"Hydrogen sulphide treatment improves post-infarct remodelling and long-term cardiac function in CSE knockout and wild-type mice"	"Ellmer LJ, Templeton EM, Pilbrow AP, Frampton C, Ishii I, Moore PK, Bhatia M, Richards AM, Cameron VA."	"Int J Mol Sci"	21	4284	2020	10.3390/ijms21124284	
"[Original Paper]"	"Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain."	"Akiyama M, Unoki T, Yoshida E, Ding Y, Yamakawa H, Shinkai Y, Ishii I, Kumagai Y.M"	"Toxicol Lett"	330	128–133	2020	10.1016/j.toxlet.2020.05.007	
"[Original Paper]"	"Increased urinary 3-mercaptolactate excretion and enhanced passive systemic anaphylaxis in mice lacking mercaptopyruvate sulfurtransferase, a model of mercaptolactate-cysteine disulfiduria"	"Akahoshi N, Minakawa T, Miyashita M, Sugiyama U, Saito C, Takemoto R, Honda A, Kamichatani W, Kamata S, Anan Y, Ishii I."	"Int J Mol Sci"	21	818	2020	10.3390/ijms21030818	
"[Original Paper]"	"Preeclampsia-like features and partial lactation failure in mice lacking cystathionine γ-lyase—an animal model of cystathioninuria."	"Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I."	"Int J Mol Sci"	20	3057	2019	10.3390/ijms20143507	
"[Original Paper]"	"Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis."	"Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couture DG, Ishii I, Bhatia M."	"Int J Mol Sci "	20	3191	2019	10.3390/ijms20133191	
"[Original Paper]"	"Environmental electrophile-mediated toxicity in mice lacking Nrf2, CSE, or both."	"Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y."	"Environ Health Perspect"	127	67002	2019	10.1289/EHP4949	
"[Original Paper]"	"Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice."	"Akahoshi N, Anan Y, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada K, Kamata S, Ishii I."	"J Nutr Biochem"	69	120-129	2019	10.1016/j.jnutbio.2019.03.020	
"[Original Paper]"	" Abnormal amino acid profiles of blood and cerebrospinal fluid from cystathionine beta-synthase-deficient mice, an animal model of homocystinuria."	"Akahoshi N, Yokohama A, Nagata T, Miura A, Kamata S, Ishii I."	"Biol Pharm Bull"	42	1054-1057	2019	10.1248/bpb.b19-00127	
"[Original Paper]"	"Mutations in homocysteine metabolism genes increase N-homocysteinylation and keratin damage in mice."	"Borowczyk K, Wróblewski J, Maria Suliburska J, Akahoshi N, Ishii I, Jakubowski H."	"Int J Genomics"	2018	7570850	2018	10.1155/2018/7570850	
"[Original Paper]"	"2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice."	"Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I."	"FEBS Open Bio"	8	1524-1543	2018	10.1002/2211-5463.12497	
"[Original paper]"	"Cystathionine gamma-lyase-produced hydrogen sulfide controls endothelial NO bioavailability and blood pressure."	"Szijarto IA, Marko L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Goulash M."	Hypertension	71	1210-1217	2018	10.1161/hypertensionaha.117.10562	
"[Original Paper]"	"Structural and functional insights into S-thiolation of human serum albumins."	"Nakashima, F. Shibata, T. Kamiya, K. Yoshitake, J. Kikuchi, R. Matsushita, T. Ishii, I. Gimenez-Bastida, J. A. Schneider, C. Uchida, K."	"Sci Rep"	8	932	2018	10.1038/s41598-018-19610-9	
"[Original Paper]"	"Hydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammation."	"Castelblanco, M. Lugrin, J. Ehirchiou, D. Nasi, S. Ishii, I. So, A. Martinon, F. Busso, N."	"J Biol Chem"	293	2546-2557	2018	10.1074/jbc.M117.806869	
"[Original Paper]"	"Rapid 2D DIGE proteomic analysis of mouse liver."	"Kamata, S. Ishii, I."	"Methods Mol Biol"	1664	153-166	2018	10.1007/978-1-4939-7268-5_13	
"[Original Paper]"	"The Capture of cadmium by reactive polysulfides attenuates cadmium-induced adaptive responses and hepatotoxicity."	"Akiyama, M. Shinkai, Y. Unoki, T. Shim, I. Ishii, I. Kumagai, Y."	"Chem Res Toxicol"	30	2209-2217	2017	10.1021/acs.chemrestox.7b00278	
"[Original Paper]"	"Hydrogen sulfide-producing cystathionine gamma-lyase is critical in the progression of kidney fibrosis."	"Han, S. J. Noh, M. R. Jung, J. M. Ishii, I. Yoo, J. Kim, J. I. Park, K. M."	"Free Radic Biol Med"	112	423-432	2017	10.1016/j.freeradbiomed.2017.08.017	
"[Original Paper]"	"Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion."	"Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K."	"Nucleic Acids Res"	45	435-445	2016	10.1093/nar/gkw745	
"[Original paper]"	"Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis."	"Gaddam R, Fraser R, Badiei A, Chambers S, Cogger V, Couture DL, Ishii I, Bhatia M."	"PLoS One"	11	e0160521	2016	10.1371/journal.pone.0160521	
"[Original paper]"	"Immobilization of the Gas Signaling Molecule H2 S by Radioisotopes: Detection, Quantification, and In Vivo Imaging."	"Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J."	"Angew Chem Int Ed Engl"	55	9365-9370	2016	10.1002/anie.201603813	
"[Original paper]"	"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)."	"Klionsky DJ, Ishii I, et al."	Autophagy	12	1-222	2016	10.1080/15548627.2015.1100356	
"[Original paper]"	"Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice."	"Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H."	Endocrinology	157	1839-1851	2016	10.1210/en.2015-1768	
"[Original paper]"	"Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation."	"Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR."	"Chem Sci"	7	3414-3426	2016	10.1039/C5SC04818D	
"[Original paper]"	"Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury."	"Markó L, Szijártó I, Filipovic MR, Kaßmann M, Balogh A, Park J-K, Przybyl L, N’diaye G, Krämer S, Anders J, Ishii I, Müller DN, Gollasch M"	"Sci Rep"	8	27517	2016	10.1038/srep27517	
"[Original paper]"	"Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice."	"Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I."	"Toxicol Appl Pharmacol"	282	195-206	2015	10.1016/j.taap.2014.11.015	
"[Original paper]"	"Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia-reperfusion injury."	"Shinmura K, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I."	"Am J Physiol Heart Circ Physiol"	308	894-903	2015	10.1152/ajpheart.00333.2014	
"[Original paper]"	"Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions."	"Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M."	"J Mol Med (Berl)"	93	879-889	2015	10.1007/s00109-015-1271-5	
"[Original paper]"	"Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress."	"Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y."	"Chem Res Toxicol"	28	838-847	2015	10.1021/tx500416y	
"[Original paper]"	"Involvement of reactive persulfides in biological bismethylmercury sulfide formation."	"Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y."	"Chem Res Toxicol"	28	1301-1306	2015	10.1021/acs.chemrestox.5b00101	
"[Original paper]"	"Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis."	"Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I."	"FEBS Open Bio"	5	357-368	2015	10.1016/j.fob.2015.04.012	
"[Original paper]"	"2D DIGE proteomic analysis highlights delayed postnatal repression of alpha-fetoprotein expression in homocystinuria model mice."	"Kamata S, Akahoshi N, Ishii I."	"FEBS Open Bio"	5	535-541	2015	10.1016/j.fob.2015.06.008	
"[Original paper]"	"The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization."	"Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE."	"Am J Physiol Lung Cell Mol Physiol"	309	710-724	2015	10.1152/ajplung.00134.2015	
"[Original paper]"	"Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides."	"Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y."	"Chem Res Toxicol"	28	1796-1802	2015	10.1021/acs.chemrestox.5b00245	
"[Original paper]"	"Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice."	"Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y."	"J Toxicol Sci"	40	837-841	2015	10.2131/jts.40.837	
"[Original paper]"	"Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice."	"Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M, Himi T, Kasahara T, Ishii I."	"Mol Nutr Food Res"	58	1309-1321	2014	10.1002/mnfr.201300758	
"[Original paper]"	"Neutral aminoaciduria in cystathionine beta-synthase-deficient mice; an animal model of homocystinuria."	"Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I."	"Am J Physiol Renal Physiol"	306	1462-1476	2014	10.1152/ajprenal.00623.2013	
"[Original paper]"	"The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse."	"Ang AD, Rivers-Auty J, Hegde A, Ishii I, Bhatia M."	"Am J Physiol Gastrointest Liver Physiol"	305	712-721	2013	10.1152/ajpgi.00044.2013	
"[Original paper]"	"Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes."	"Okamoto M, Yamaoka M, Takei M, Ando T, Taniguchi S, Ishii I, Tohya K, Ishizaki T, Niki I, Kimura T."	"Biochem Biophys Res Commun"	442	227-233	2013	10.1016/j.bbrc.2013.11.023	
[Review]	"Reconsideration of homocysteinemia."	"Ishii I."	Seikagaku	85	1067-1071	2013		
"[Original paper]"	"Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine gamma-lyase in the pancreatic beta-cell."	"Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I."	"Mol Cell Endocrinol"	350	31-38	2012	10.1016/j.mce.2011.11.016	
"[Original paper]"	"TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates."	"Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I."	"Anal Bioanal Chem"	402	1859-1864	2012	10.1007/s00216-011-5647-2	
"[Original paper]"	"Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3."	"Harada Y, Ishii I, Hatake K, Kasahara T."	"Cancer Lett"	319	83-88	2012	10.1016/j.canlet.2011.12.034	
"[Original paper]"	"Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway."	"Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, Nagahata Y, Ishikawa M, Hattori K, Takenouchi T, Takahashi T, Ishii I, Matsubara K, Kabe Y, Uchiyama S, Nagata E, Gadalla MM, Snyder SH, Suematsu M."	"Proc Natl Acad Sci USA"	109	1293-1298	2012	10.1073/pnas.1119658109	
"[Original paper]"	"Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria."	"Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I."	"Free Radic Biol Med"	52	1716-1726	2012	10.1016/j.freeradbiomed.2012.02.033	
[Review]	"Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration."	"Ishii I, Harada Y, Kasahara T."	"Front Oncol"	2	137	2012	10.3389/fonc.2012.00137	
"[Original paper]"	"Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria."	"Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I."	"Anal Bioanal Chem"	400	1853-1863	2011	10.1007/s00216-011-4703-2	
"[Original paper]"	"Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2."	"Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I."	"Epilepsy Behav"	22	659-665	2011	10.1016/j.yebeh.2011.09.002