種別	タイトル	著者	誌名	巻号	ページ	出版年	DOI	URL
"[Original paper]"	"A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice."	"Ishii I, Kamata S, Ito S, Shimonaga A, Koizumi M, Tsushima M, Miura A, Nagata T, Tosaka Y, Ohtani H, Kamichatani W, Akahoshi N."	"Int J Mol Sci."	23	928	2022	10.3390/ijms23020928.	
[Review]	硫化水素産生・代謝酵素の役割：ヒト遺伝病と病態モデルマウスからの知見	"Akahoshi N,  Ishii I."	"Journal of Japanese Biochemical Society "	93	754-759	2021	10.14952/SEIKAGAKU.2021.930754	
"[Original paper]"	"Homocysteine Hypothesis on the Impaired Peripheral but Not Central Nervous System Oxytocin Responses in Cystathionine γ-Lyase-Deficient Dam Mice."	"Akahoshi N, Kamichatani W, Ishii I."	"Biol Pharm Bull."	43	1810-1813	2020	10.1248/bpb.b20-00676.	
"[Original paper]"	"Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines."	"Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I."	"Toxicol In Vitro."	69	104999	2020	10.1016/j.tiv.2020.104999.	
"[Original paper]"	"Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria. "	"Akahoshi N, Minakawa T, Miyashita M, Sugiyama U, Saito C, Takemoto R, Honda A, Kamichatani W, Kamata S, Anan Y, Ishii I."	"Int J Mol Sci."	21	818	2020	10.3390/ijms21030818.	
"[Original paper]"	"Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4."	"Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S."	"J Clin Invest."	130	4332-4349	2019	10.1172/JCI121955.	
"[Original paper]"	"Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria."	"Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I"	"Int J Mol Sci."	20	E3507	2019	10.3390/ijms20143507.	
"[Original paper]"	"Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria. "	"Akahoshi N, Yokoyama A, Nagata T, Miura A, Kamata S, Ishii I"	"Biol Pharm Bull."	42	1054-1057	2019	10.1248/bpb.b19-00127.	
"[Original paper]"	"Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice."	"Akahoshi N*, Anan Y*, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada KI, Kamata S, Ishii I"	"J Nutr Biochem."	69	120-129	2019	10.1016/j.jnutbio.2019.03.020.	
"[Original paper]"	"The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity."	"Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T."	"JCI Insight."	3	97293	2018	10.1172/jci.insight.97293.	
"[Original paper]"	"Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice."	"Borowczyk K, Wróblewski J, Suliburska J, Akahoshi N, Ishii I, Jakubowski H."	"Int J Genomics."	2018	7570850	2018	10.1155/2018/7570850	
"[Original paper]"	"2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice."	"Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I."	"FEBS Open Bio."	8	1524-1543	2018	10.1002/2211-5463.12497.	
"[Original paper]"	"Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure."	"Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M."	Hypertension	71	1210-1217	2018	"10.1161/HYPERTENSIONAHA.117.10562. "	
"[Original paper]"	"LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model."	"Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, Ishii S, Akahoshi N, Yanagida K, Sumida H, Araki M, Araki K, Yamamura KI, Murakami-Murofushi K, Ueda H."	"J Pharmacol Sci."	136	93-96	2018	10.1016/j.jphs.2018.01.001.	
"[Original paper]"	"Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility."	"Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E."	"eLife "	5	e10561	2016		
"[Original paper]"	"Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes."	"Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M"	"Int Immuno"	28	283-292	2016		
"[Original paper]"	"2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice."	"Kamata S, Akahoshi N, Ishii I"	"FEBS Open Bio"	5	535-541	2015		
"[Original paper]"	"Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions."	"Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M"	"J Mol Med"	93	879-889	2015		
"[Original paper]"	"The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells."	"Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S"	"Sci Rep "	5	11410	2015		
"[Original paper]"	"Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice."	"Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I"	"Toxicol Appl Pharmacol "	282	195-206	2015		
"[Original paper]"	"Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria."	"Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I"	"Am J Physiol Renal Physiol "	306	F1462-F1476	2014		
"[Original paper]"	"TDAG8 activation inhibits osteoclastic bone resorption."	"Hikiji H, Endo D, Horie K, Harayama T, Akahoshi N, Igarashi H, Kihara Y, Yanagida K, Takeda J, Koji T, Shimizu T, Ishii S"	"FASEB J"	28	871-879	2014		
"[Original paper]"	"Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria."	"Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I"	"Free Radic Biol Med"	52	1716-1726	2012		
"[Original paper]"	"TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates."	"Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I"	"Anal Bioanal Chem"	402	1859-1864	2011		
"[Original paper]"	"Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria."	"Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I"	"Anal Bioanal Chem"	400	1853-1863	2011		
"[Original paper]"	"Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2."	"Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I"	"Epilepsy Behav"	22	659-665	2011		
"[Original paper]"	"Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury."	"Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M"	"J Biol Chem"	285	26358-26368	2010		
"[Original paper]"	"Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia."	"Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I"	"Hum Mol Genet"	17	1994-2005	2008		
"[Original paper]"	"Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures."	"Akahoshi N, Murashima YL, Himi T, Ishizaki Y, Ishii I"	"Neurosci Lett"	429	136-141	2007		
[Review]	システイン生合成経路の破綻による病態.	"石井功, 赤星軌征"	アミノ酸研究	1	37-39	2007		
"[Original paper]"	"Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation."	"Akahoshi N, Izumi T, Ishizaki Y, Ishii I"	"Biol Pharm Bull"	29	1799-1802	2006		
"[Original paper]"	"Murine cystathionine γ-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression."	"Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, and Kimura H"	"Biochem J"	381	113-123	2004