種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL "Original article, " "Variants of Flavin-containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources. " "Makiguchi, M., Shimizu, M., Yokota, Y., Shimamura, E., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H. " "Drug Metab Dispos." 51 884-891 2023 10.1124/dmd.123.001310 https://www.ncbi.nlm.nih.gov/pubmed/37041084 "Original article, " "Plasma and hepatic exposures of celecoxib and diclofenac prescribed alone in patients with cytochrome P450 2C9*3 modeled after virtual oral administrations and likely associated with adverse drug events reported in a Japanese database" "Adachi, K., Ohyama, K., Tanaka, Y., Nakano, H., Sato, T., Murayama, N., Shimizu, M., Saito, Y., and Yamazaki, H. " "Bio Pharm Bull" 46 856-863 2023 10.1248/bpb.b23-00189 https://www.ncbi.nlm.nih.gov/pubmed/37062721 "Original article, " "HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. " "Uehara, S., Higuchi, Y., Yoneda, N., Ito, R., Takahashi, T., Murayama, N., Yamazaki, H., Murai, K., Hikita, H., and Takehara, T. " "Biochem Biophys Res Commun" 663 132-141 2023 10.1016/j.bbrc.2023.04.054 https://www.ncbi.nlm.nih.gov/pubmed/37121123 "Original article, " "Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs" "Uno Y, Noda Y, Morikuni S, Murayama N, Yamazaki H. " "Xenobiotica " 53 140-148 2023 10.1080/00498254.2023.2211673 https://www.ncbi.nlm.nih.gov/pubmed/37144920 "Original article, " "Liver and plasma concentrations of food chemicals after virtual oral doses extrapolated using in silico estimated input pharmacokinetic parameters to confirm reported liver toxicity in rats. " "Adachi K., Nakano H., Sato T., Shimizu M., and Yamazak, H." "Bio Pharm Bull " 46 "in press" 2023 10.1248/bpb.b23-00358 https://www.ncbi.nlm.nih.gov/pubmed/37316265 "Original article, " "Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients. " "Adachi K, Utsumi M, Sato T, Nakano H, Shimizu M, and Yamazaki H. " "Bio Pharm Bull" 46 "in press" 2023 10.1248/bpb.b23-00371 https://www.ncbi.nlm.nih.gov/pubmed/37380443 "Original article, " "A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis – a potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir. " "Unita R, Adachi K, Inada A, Shimizu M, Beppu S, Yamazaki H." "J Infect Chemother" "in press" 2023 "DOI: 10.1016/j.jiac.2023.07.001" Review, "US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations. " "Gori, G. B., Aschner, M., Borgert, C. J., Cohen, S. M., Dietrich, D. R., Galli, C. L., Greim, H., Heslop‑Harrison, J. S., Kacew, S., Kaminski, N. E., Klaunig, J. E., Marquardt, H. W. J., Pelkonen, O., Roberts, R., Savolainen, K. M., Tsatsakis·, A., and Yamazaki, H." "Archives of Toxicology" 97 1813-1822 2023 10.1007/s00204-022-03429-5 https://www.ncbi.nlm.nih.gov/pubmed/37029818 "Original article, " "2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22. " "Uno, Y.; Morikuni, S.; Murayama, N.; Yamazaki, H. " Xenobiotica 53 60-65 2023 10.1080/00498254.2023.2197037 https://www.ncbi.nlm.nih.gov/pubmed/36976910 "Original article, " "Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs." "Uno, Y., Morikuni, S., Shiraishi, M., Asano, A., Murayama, N., and Yamazaki, H. " "Drug Metab Dispos" 51 637-644 2023 10.1124/dmd.122.001236 https://www.ncbi.nlm.nih.gov/pubmed/36754837 "Original article, " "Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19. " "Ushirozako, G., Noda, Y., Murayama, N., Kawaguchi, H., Tsukiyama-Kohara, K., Yamazaki, H., and Uno, Y. " "Drug Metab Dispos" 51 610-617 2023 10.1124/dmd.122.001152 https://www.ncbi.nlm.nih.gov/pubmed/36669854 "Original article, " "Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. " "Uehara, S., Higuchi, Y., Yoneda, N., Kato, H., Yamazaki, H., and Suemizu, H." "Drug Metab Dispos" 51 480-491 2023 10.1124/dmd.122.001102 https://www.ncbi.nlm.nih.gov/pubmed/36623885 "Original article, " "Roles of human cytochrome P450 3A4/5 in dexamethasone 6beta-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin. " "Uehara, S., Shimizu, M., Suemizu, H., and Yamazaki, H. " "Drug Metab Pharmacokinet" 49 100504 2023 10.1016/j.dmpk.2023.100504. "Original article, " "Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes " "Uno, Y., Jikuya, S., Noda, Y., Oguchi, A., Murayama, N., Kawaguchi, H., Tsukiyama-Kohara, K., and Yamazaki, H. " "Comp Biochem Physiol C Toxicol Pharmacol" 267 109579 2023 10.1016/j.cbpc.2023.109579 https://www.ncbi.nlm.nih.gov/pubmed/36822299 "Original article, " " A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria. " "Shimizu, M., Yamamoto, A., Makiguchi, M., Shimamura, E., Yokota, Y., Harano, M., and Yamazaki, H. " "Drug Metab Pharmacokinet" 48 100490, 2023 10.1016/j.dmpk.2023.100490 https://www.ncbi.nlm.nih.gov/pubmed/36889044 "Original article, " "Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes" "Uno, Y., Noda, Y., Murayama, N., Tsukiyama-Kohara, K., and Yamazaki, H." "Comp Biochem Physiol C" 265 109534 2023 10.1016/j.cbpc.2022.109534 https://www.ncbi.nlm.nih.gov/pubmed/36563947 "Original article, " "High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4*16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database. " "Adachi, K., Ohyama, K., Tanaka, Y., Sato, T., Murayama, N., Shimizu, M., Saito, Y., and Yamazaki, H. " "Drug Metab Pharmacokinet" 49 100486, 2023 10.1016/j.dmpk.2022.100486 https://www.ncbi.nlm.nih.gov/pubmed/36746706 Review, "Species specificity and selection of models for drug oxidations mediated by polymorphic human enzymes. " "Yamazaki, H., and Shimizu, M. " "Drug Metab Dispos" 51 123-129 2023 10.1124/dmd.121.000742 https://www.ncbi.nlm.nih.gov/pubmed/35772770 "Original article, " "A Comprehensive Investigation of Dog Cytochromes P450 3A (CYP3A) Reveales A Functional Role of Newly Identified CYP3A98 in Small Intestine" "Uno, Y., Jikuya, S., Noda, Y., Murayama, N., and Yamazaki, H. " "Drug Metab Dispos" 51 38-45 2023 10.1124/dmd.121.000749 https://www.ncbi.nlm.nih.gov/pubmed/35772769 "Original article, " "A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs. " "Uno, Y., Morikuni, S., Shiraishi, M., Asano, A., Kawaguchi, H., Murayama, N., and Yamazaki, H. " Xenobiotica 52 963-972 2022 10.1080/00498254.2022.2148139 https://www.ncbi.nlm.nih.gov/pubmed/36373600 "Original article, " "Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolizing enzymes. " "Uno Y, Ushirozako G, Uehara S, Murayama N, Fujiki Y, Kawaguchi H, Tsukiyama-Kohara K, and Yamazaki H. " Xenobiotica 52 687-696 2022 10.1124/dmd.122.001152 https://www.ncbi.nlm.nih.gov/pubmed/36669854 "Original article, " "Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2" "Kojima A, Nadai M, Murayamam N, Yamazaki H, Katoh M." Xenobiotica 52 669-675 2022 10.1080/00498254.2022.2137068 https://www.ncbi.nlm.nih.gov/pubmed/36251932 "Original article, " "Forward and Reverse Dosimetry for Aniline and 2,6-Dimethylaniline in Humans Extrapolated from Humanized-liver Mouse Data Using Simplified Physiologically Based Pharmacokinetic Models." "Miura, T., Uehara, S., Shimizu, M., Suemizu, H., and Yamazaki, H. " "J Toxicol Sci" 47 531-538 2022 10.2131/jts.47.531 https://www.ncbi.nlm.nih.gov/pubmed/36450497 "Original article, " "Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans. " "Adachi K, Shimizu M, Yamazaki H. " "Biol Pharm Bull" 45 1812-1817 2022 10.1248/bpb.b22-00502 https://www.ncbi.nlm.nih.gov/pubmed/36171106 "Original article, " "Updated in Silico Prediction Methods for Fractions Absorbed and Absorption Rate Constants of 372 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models for Estimating Internal Concentrations in Rats" "Adachi K, Shimizu M, and Yamazaki H. " "J Toxicol Sci" 47 453-456 2022 10.2131/jts.47.453 https://www.ncbi.nlm.nih.gov/pubmed/36328535 "Original article, " "Combined risk assessment of food-derived coumarin with in silico approaches. " "Yamada, T., Katsutani, N., Maruyama, T., Kawamura, T., Yamazaki, H., Murayama, N., Tong, W., Yamazoe, Y., and Hirose, A. " "Food Safety " 10 73-82 2022 10.14252/foodsafetyfscj.D-21-00015 https://www.ncbi.nlm.nih.gov/pubmed/36237397 "Original article, " "Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism" "Uehara S, Iida Y, Ida-Tanaka M, Goto M, Kawai K, Yamamoto M, Higuchi Y, Ito S, Takahashi R, Kamimura H, Ito M, Yamazaki H, Oshimura M, Kazuki Y, Suemizu H. " "Sci Rep" 12 14907 2022 10.1038/s41598-022-19242-0 https://www.ncbi.nlm.nih.gov/pubmed/36050438 "Original article, " "Correction to ""An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats."" " "Kamiya, Y., Handa, K., Miura, T., Ohori, J., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H" "Chem Res Toxicol" 35 1433 2022 10.1021/acs.chemrestox.2c00225 https://www.ncbi.nlm.nih.gov/pubmed/35905009 "Original article, " 市販の鎮痛薬を過量摂取し急性カフェイン中毒を来した14歳女児 "神野太郎、進藤淳也、相澤魁人、西田光宏、清水万紀子、山崎浩史、上牧 務 " 小児科臨床 754 275-280 2022 "Original article, " "Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria." "Shimizu, M., Hirose, N., Kato, M., Sango, H., Uenuma, Y., Makiguchi, M., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H." "Drug Metab Pharmacokinet" 46 100465 2022 10.1016/j.dmpk.2022.100465 https://www.ncbi.nlm.nih.gov/pubmed/35853340 "Original article, " "Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. " "Ogiya D, Murayama N, Kamiya Y, Saito R, Shiraiwa S, Suzuki R, Machida S, Tazume K, Ando K, Yamazaki H." "Ann Hematol" 101 2013-2019 2022 10.1007/s00277-022-04893-w https://www.ncbi.nlm.nih.gov/pubmed/35732975 "Original article, " "Molecular and functional characterization of N-acetyltransferases in common marmosets and pigs" "Uno, Y., Uehara, S., Ijiri, M., Kawaguchi, H., Asano, A., Shiraishi, M., Banju, K., Murayama, N., and Yamazaki, H" "Drug Metab Dispos" 50 1429-1433 2022 10.1124/dmd.122.000919 https://www.ncbi.nlm.nih.gov/pubmed/35768074 "Original article, " "Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus. " "Negishi, D., Mitsumatsu, O., Matsumura, T., Mitsumatsu, H., Makiguchi, M., Shimizu, M., and Yamazaki, H. " "J Pharm Health Care Sci" 8 16 2022 10.1186/s40780-022-00248-9 https://www.ncbi.nlm.nih.gov/pubmed/35773734 "Original article, " "Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats." "Uno, Y., Shimizu, M., Ogawa, Y., Makiguchi, M., Kawaguchi, H., Yamato, O., Ishizuka, M., and Yamazaki, H. " "Biochem Pharmacol" 202 115125 2022 10.1016/j.bcp.2022.115125 https://www.ncbi.nlm.nih.gov/pubmed/35690111 "Original article, " "Cytochrome P450 2J (CYP2J) Genes in Dogs, Cats, and Pigs Are Expressed and Encode Functional Drug-Metabolizing Enzymes. " "Uno Y, Murayama N, Ijiri M, Kawaguchfi H, Yamato O, Shiraishi M, Asano A, Teraoka H, Mizukawa H, Nakayamae SMM, Ikenaka Y, Ishizuka M, and Yamazaki H." "Drug Metab Dispos" 50 1434-1441 2022 10.1124/dmd.122.000930 https://www.ncbi.nlm.nih.gov/pubmed/35701183 "Original article, " "Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals" "Shimizu M, Hayasaka R, Kamiya Y, and Yamazaki H. " "Biol Pharm Bull" 45 1142-1157 2022 10.1248/bpb.b22-00221 https://www.ncbi.nlm.nih.gov/pubmed/35644566 Review "Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans" "Uno, Y., Uehara, S., and Yamazaki, H. " "Biochem Pharmacol" 197 "114887 " 2022 10.1016/j.bcp.2021.114887 https://www.ncbi.nlm.nih.gov/pubmed/34968483 "Original article, " "Uehara S, Murayama N, Higuchi Y, Yoneda N, Yamazaki H, and Suemizu H." "Comparison of mouse and human cytochrome P450 mediated-drug metabolizing activities in hepatic and extrahepatic microsomes." Xenobiotica 52 229-239 2022 10.1080/00498254.2022.2066581 https://www.ncbi.nlm.nih.gov/pubmed/35416115 "Original article, " "Shimada T, Nagayoshi H, Murayama N, Sawai A, Kim V, Kim D, Yamazaki H, Guengerich FP, and Takenaka S." " Oxidation of 3´-methoxyflavone, 4´-methoxyflavone, and 3´,4´-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13." Xenobiotica 52 134-145 2022 10.1080/00498254.2022.2062486 https://www.ncbi.nlm.nih.gov/pubmed/35387543 "Original article, " "Uehara, S., Yoneda, N., Higuchi, Y., Yamazaki, H., and Suemizu, H." "Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers. " "Drug Metab Pharmacokinet" 44 100454 2022 10.1016/j.dmpk.2022.100454 https://www.ncbi.nlm.nih.gov/pubmed/35378494 "Original article, " "Uehara, S., Shimizu, M., Plé, K., Routier, S., Yoneda, N., Higuchi, Y., Suemizu, H., and Yamazaki, H. " "Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo. " "Drug Metab Pharmacokinet," 44, 100453 2022 10.1016/j.dmpk.2022.100453 https://www.ncbi.nlm.nih.gov/pubmed/35381575 "Original article, " "安達昂一郎、別府 賢、清水万紀子、福田利明、山崎浩史" 救急搬送事例となった企図的過量服用医薬品等の適正投与時の生理学的薬物動態モデルを用いた血中薬物動態再現の基盤研究 中毒研究 35 179-185 2022 "Original article, " "Plasma concentration profiles for hepatotoxic pyrrolizidine alkaloid senkirkine in humans extrapolated from rat data sets using a simplified physiologically based pharmacokinetic model" "Kamiya, Y., Miura, T., Kato, A., Murayama, N., Shimizu, M., and Yamazaki, H." "Drug Metab Bioanal Lett," 15 64-69 2022 "White paper, " "Imaging Mass Spectrometry (IMS) for Drug Discovery and Development Survey: Results on Methods, Applications and Regulatory Compliance" "Solon E, Groseclose MR, Ho S, Tanaka K, Nakada N, Linehan S, Nishidate M, Yokoi H, Kaji H, Urasaki Y, Watanabe K, Ishida T, Komatsu R, Yoshida K, Yamazaki H, Saito K, Saito Y, and Tanaka Y. " "Drug Metab Pharmacokinet" 43 100438 2022 10.1016/j.dmpk.2021.100438 https://www.ncbi.nlm.nih.gov/pubmed/35091331 "Original article, " "Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals" "Kamiya, Y., Handa, K., Miura, T., Ohori, J., Kato, A., Shimizu, M., Kitajima, M., and Yamazaki, H. " "Biol Pharm Bull" 45 124-128 2022 10.1248/bpb.b21-00769 https://www.ncbi.nlm.nih.gov/pubmed/34732590 "Original article, " "An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. " "Uehara, S., Higuchi, Y., Yoneda, N., Kawai, K., Yamamoto, M., Kamimura, H., Iida, Y., Oshimura, M., Kazuki, Y., Yamazaki, H., Hikita, H., Takehara, T., and Suemizu, H. " "Drug Metab Pharmacokinet" 42 100410 2022 10.1016/j.dmpk.2021.100410 https://www.ncbi.nlm.nih.gov/pubmed/34839181 "Original article, " "Systematic identification and characterization of cynomolgus macaque solute carrier transporters" "Uno Y, Yamazaki H." "Drug Metab Pharmacokinet " 43 100437 2022. 10.1016/j.dmpk.2021.100437 https://www.ncbi.nlm.nih.gov/pubmed/35081498 Review "Meet the Editorial Board Member" "Yamazaki, H. " "Drug Metab. 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"Drug Metab Pharmacokinet" 41 100420 2021 10.1016/j.dmpk.2021.100420 https://www.ncbi.nlm.nih.gov/pubmed/34634752 "Original article, " " Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice. " "Miura T, Uehara S, Shimizu M, Murayama N, Suemizu H, Yamazaki H." "J Toxicol Sci" 46 525-530 2021 10.2131/jts.46.525 https://www.ncbi.nlm.nih.gov/pubmed/34719555 "Original article, " "Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital." "Adachi, K., Sugitani, Y., Unita, R., Yoshida, K., Beppu, S., Terashima, M., Fujii, M., Shimizu, M., and Yamazaki, H. " "J Pharm Health Care Sci" 7 33 2021 10.1186/s40780-021-00216-9 https://www.ncbi.nlm.nih.gov/pubmed/34488903 "Original article, " "Differences in pharmacokinetics and haematotoxicities of aniline and its dimethyl derivatives orally administered in rats." "Miura, T., Kamiya, Y., Murayama, N., Shimizu, M., and Yamazaki, H. " "Biol. Pharm. Bull" 44 1775-1780 2021 10.1248/bpb.b21-00589 https://www.ncbi.nlm.nih.gov/pubmed/34433705 "Original article, " "Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital" "Adachi, K., Beppu, S., Terashima, M., Fukuda, T., Tomizawa, J., Shimizu, M., and Yamazaki, H. " "J Pharm Health Care Sci, " 7 36 2021 10.1186/s40780-021-00220-z https://www.ncbi.nlm.nih.gov/pubmed/34602096 "Original article, " "Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes. " "Uehara, S., Yoneda, N., Higuchi, Y., Yamazaki, H., and Suemizu, H. " "Drug Metab Pharmacokinet" 41 100419 2021 10.1016/j.dmpk.2021.100419 https://www.ncbi.nlm.nih.gov/pubmed/34624627 "Original article, " "UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised livers. " "Uehara S, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H. " Xenobiotica 51 1146-1154 2021 10.1080/00498254.2021.1972492 https://www.ncbi.nlm.nih.gov/pubmed/34423713 "Original article, " "Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning" "Kamiya, Y., Omura, A., Hayasaka, R., Saito, R., Sano, I., Handa, K., Ohori, J., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H." "Biochem Pharmacol" 192 114749 2021 10.1016/j.bcp.2021.114749 "Original article, " "Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital" "Adachi, K., Beppu, S., Terashima, M., Kobari, W., Shimizu, M., and Yamazaki, H. . " "Journal of Pharmaceutical Health Care and Sciences" 7 32 2021 "Original article, " "Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes. " "Nagayoshi, H., Murayama, N., Takenaka, S., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada, T." Xenobiotica 51 995-1009 2021 10.1080/00498254.2021.1950866 https://www.ncbi.nlm.nih.gov/pubmed/34224301 "Original article, " "Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model " "Yanagi M, Kamiya Y, Murayama N, Banju K, Shimizu M, Yamazaki H. " "J Toxicol Sci " 46 391-399 2021 "Original article, " "Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes. " "Taniguchi-Takizawa, T., Kato, N., Shimizu, M., Kume, T., and Yamazaki, H. " "Drug Metab Pharmacokinet" 40 "100412 " 2021 "Original article, " "Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations. " "Murayama, N. and Yamazaki, H. " "J Toxicol Sci" 46 371-378 2021 "Original article, " " Differences in hydrolase activities in the liver and small intestine between marmosets and humans. " "Honda, S., Fukami, T., Hirosawa, K., Tsujiguchi, T., Zhang, Y., Nakano, M., Uehara, S., Uno, Y., Yamazaki, H., and Nakajima, M." "Drug Metab Dispos," 49 718-728 2021 10.1124/dmd.121.000513 "Original article, " "Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: Insights into future personalized treatments. " "Yamazaki, H., Shimizu, M., Otani, T., Mizugaki, A., Mure, K., Suzuki, S., and Ishikawa, H. " "J Pharm Health Care Sci" " 7" 26 2021 10.1186/s40780-021-00209-8 "Original article, " "Pharmacokinetics of Primary Oxidative Metabolites of Thalidomide in Rats and in Chimeric Mice Humanized with Different Human Hepatocytes. " "Miura, T., Uehara, S., Shimizu, M., Suemizu, H., and Yamazaki, H. 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" " Regul.Toxicol.Pharmacol." 101 A1-A2 2019 https://doi.org/10.1016/j.yrtph.2018.12.015 "Original article, " "Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6" "Uehara, S., Murayama, N., Yamazaki, H., and Suemizu, H." Xenobiotica 49 1321-1331 2019 10.1080/00498254.2018.1564401. "Original article, " "Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver" "Iwata, H., Goto, M., Sakai, N., Suemizu, H., and Yamazaki, H. " Xenobiotica 49 1311-1322 2019 10.1080/00498254.2018.1564087 "Original article, " "Plasma and hepatic concentrations of chemicals after virtual oral administrations extrapolated using rat plasma data and simple physiologically based pharmacokinetic models. " "Kamiya, Y., Otsuka, S., Miura, T., Takaku, H., Yamada, R., Nakazato, M., Nakamura, H., Mizuno, S., Shono, F., Funatsu, K., and Yamazaki, H." "Chem. 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J.Med.Primatol 48 51–53 2019 "http://dx.doi.org/10.1111/jmp.12385 " "Original article, " "In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions" "Makino, C., Watanabe, A, Deguchi, T., Shiozawa, H., Scheck, I., Rozehnal, V., Ishizuka, T., Watanabe, N., Ando, O., Murayama, N., and Yamazaki, H. " Xenobiotica 49 961-969 2019 "Original article, " "In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys, and humans" "Koyanagi, T., Yano, K., Kim, S., Murayama, N., Yamazaki, H., and Tamai, I. " Xenobiotica 49 887-894 2019 "Original article, " "Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes" "Nagayoshi, H., Murayama, N., Kakimoto, K., Takenaka, S., Kitahara, J., Lim, Y.-R., Kim, V., Kim, D., Yamazaki, H., Komori, M., Guengerich, F. P., and Shimada, T. " Xenobiotica 49 791-802 2019 "Original article, " "Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanized livers" "Uehara, S., Higuchi, Y., Yoneda, N., Yamazaki, H., and Suemori, H. " Xenobiotica 49 678-687 2019 "Original article, " "Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates" "Shimura, K., Murayama, N., Tanaka, S., Onozeki, S., and Yamazaki, H. " Xenobiotica 49 557-562 2019 10.1080/00498254.2018.1482576 "Original article, " "Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate" "Miura T, Suemizu H, Goto M, Sakai N, Iwata H, Shimizu M and Yamazaki H." Xenobiotica 49 513-520 2019 10.1080/00498254.2018.1471753 "Original article, " "Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver" "Oshio, T., Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H." Xenobiotica 3 265–269 2019 "doi: 10.1080/00498254.2018.1439204. " https://www.ncbi.nlm.nih.gov/pubmed/29417863 "Review article," "Importance of cynomolgus monkeys in development of monoclonal antibody drugs." "Iwasaki K, Uno Y, Utoh M and Yamazaki H." "Drug Metab. Pharmacokinet." 34 55-62 2019 https://www.ncbi.nlm.nih.gov/pubmed/29655914 "Original article, " "Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone" "Kakimoto, K., Murayama, N., Takenaka, S., Nagayoshi, H., Lim, Y.-R., Kim, V., Kim, D., Yamazaki, H., Komori, M., Guengerich, F. P., and Shimada, T. " Xenobiotica 49 131-142 2019 "doi: 10.1080/00498254.2018.1426133" https://www.ncbi.nlm.nih.gov/pubmed/29310511 "Original article, " "Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks" "Murayama, N. and Yamazaki, H." J.Toxicol.Sci. 43 241-245 2018 " https://doi.org/10.2131/jts.43.241" "Original article, " "Improved intranasal retentivity and transnasal absorption enhancement by PEGylated poly-L-ornithine." "Kamiya, Y., Yamaki, T., Omori, S., Uchida, M., Ohtake, K., Kimura, M., Yamazaki, H., and Natsume, H. " Pharmaceuticals, 11 9 2018 "Original article, " "Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques. " "Uno, Y., Uehara, S., Murayama, N., and Yamazaki, H. " "Chem. Res. Toxicol." 31 1373-1381 2018 10.1021/acs.chemrestox.8b00257 "Original article, " "Molecular and functional characterization of N-acetyltransferases NAT1 and NAT2 in cynomolgus macaque" "Uno, Y., Murayama, N., and Yamazaki, H. " "Chem. Res. Toxicol." 31 1269-1276 2018 10.1021/acs.chemrestox.8b00236 "Original article, " "Genetic variants of glutathione S-transferase GSTT1 and GSTT2 in cynomolgus macaques: identification of GSTT substrates and functionally relevant alleles. " "Uno, Y., Murayama, N., Kato, M., Tanaka, S., Ohkoshi, T., and Yamazaki, H. " "Chem. Res. Toxicol." 31 1086-1091 2018 10.1021/acs.chemrestox.8b00198 "Commentaly, " "Obfuscating Transparency? " "Marquardt,H.W.J., Autrup,H., Berry,C.L., Boobis,A.R., Cohen,S.M., Dekant,W., Galli,C.L., Goodman,J.I., Gori,G.B., Greim,H.A., Kaminski,N.E., Klaassen,C.D., Klaunig,J.E., Lotti,M., Marquardt,H.W.J., Moretto,A., Pelkonen,O., Sipes,I.G., Wallace,K.B., and Yamazaki,H. " "Regul. Toxicol. Pharmacol." 97 A1-A3 2018 https://doi.org/10.1016/j.yrtph.2018.07.004 "Original article, " "Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques. " "Uno, Y., Takahira, R., Murayama, N., Ishii, Y., Ikenaka, Y., Ishizuka, M., Yamazaki, H., and Ikushiro, S. " "Biochem. Pharmacol.," 155 172-181 2018 "DOI: 10.1016/j.bcp.2018.06.027" https://www.ncbi.nlm.nih.gov/pubmed/29944869 "Original article, " "Collaborative method performance study of the measurement of nicotine, its metabolites, and total 3 nicotine equivalents in human urine" "Wang L, Bernert JT, Benowitz NL, Feng.J., Jacob III P, McGaheea E, Caudilla SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL. " "Cancer Epidemiol Biomarker Prev" 27 1-8 2018 10.1158/1055-9965.EPI-17-1127 https://www.ncbi.nlm.nih.gov/pubmed/29853481 "Original article, " "In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants" "Nakanishi, K., Uehara, S., Kusama, T., Inoue, T., Shimura, K., Kamiya, Y., Murayama, N., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H" "Biochem. Pharmacol." "152 " 272-282 2018 "doi: 10.1016/j.bcp.2018.04.002" https://www.ncbi.nlm.nih.gov/pubmed/29626440 "Original article, " "Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver" "Nakayama, K., Ito, S., Suzuki, M., Takubo, H., Yamazaki, H., and Nomura, Y" Xenobiotica 49 404-414 2018 "doi: 10.1080/00498254.2018.1460516" https://www.ncbi.nlm.nih.gov/pubmed/29619871 "Original article, " "Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice" "Shimizu, M., Suemizu, H., Mizuno, S., Kusama, T., Miura, T., Uehara, S., and Yamazaki, H." "J.Toxicol. Sci." 43 387-393 2018 "Original article, " " Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity dete,cted by human serum albumin RNA. " "Murayama,N., Suemizu,H., Uehara,S., Kusama,T. Mitsui,M., Kamiya,Y., Shimizu,M., Guengerich,F. P., and Yamazaki,H." "J. Toxicol.Sci," 43 369-375 2018 https://doi.org/10.2131/jts.43.369 "Original article, " "Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques" "Uno, Y., Uehara, S., and Yamazaki, H. " " J.Med.Primatol. " 47 232-237 2018 "DOI: 10.1111/jmp.12336" "Review article," "Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans" "Uno, Y., Uehara, S., and Yamazaki, H. " "Biochem. Pharmacol." "153 " 184-195 2018 "doi: 10.1016/j.bcp.2017.12.015." https://www.ncbi.nlm.nih.gov/pubmed/29277691 "Original article, " "Dihydrocodeine overdoses in a neonate and in a 14-year-old girl who were both genotyped as cytochrome P450 2D6*1/*10-*36: comparing developmental ages and drug monitoring data with the results of pharmacokinetic modeling" "Shimizu, M. Kondo, T. Fukuoka, T. Tanaka, T. and Yamazaki, H." "Ther. Drug Monit." 40 162-165 2018 10.1097/FTD.0000000000000482 https://www.ncbi.nlm.nih.gov/pubmed/29389842 "Original article, " "Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure" "Suemizu, H., Kawai, K., Murayama, N., Nakamura, M., and Yamazaki, H." "Pest Manag.Sci" 74 1424-1430 2018 "doi: 10.1002/ps.4825" https://www.ncbi.nlm.nih.gov/pubmed/29235720 "Original article, " " In vivo analysis of the anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone as a guide for safety pharmacological evaluation of antiarrhythmic drugs. " "Motokawa, Y., Nakamura, Y., Hagiwara-Nagasawa, M., Goto, A., Chiba, K., Lubna, N. J., Izumi-Nakaseko, H., Ando, K., Naito, A. T. , Yamazaki, H., and Sugiyama, A." "Cardiovasc. Toxicol., " 18 242-251 2018 "doi: 10.1007/s12012-017-9434-y" https://www.ncbi.nlm.nih.gov/pubmed/29139031 "Original article, " "Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies" "Murayama, N., Yajima, K., Hikawa, M., Shimura, K., Ishii, Y., Takada, M., Uno, Y., Utoh, M., Iwasaki, K., and Yamazaki, H. " "Biopharm. Drug Dispos." 39 115-121 2018 "doi: 10.1002/bdd.2115" https://www.ncbi.nlm.nih.gov/pubmed/29136681 "Original article, " "Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models" "Kusama, T., Toda, A., Shimizu, M., Uehara, S., Inoue, T., Uno, Y., Utoh, M., Sasaki, E., and Yamazaki, H. " Xenobiotica, 48 1072-1077 2018 10.1080/00498254.2017.1393121 https://www.ncbi.nlm.nih.gov/pubmed/29034770 "Original article, " "Molecular cloning and tissue distribution of a novel marmoset ABC transporter" "Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. " "Biopharm. Drug Dispos." 39 59-63 2018 "doi: 10.1002/bdd.2111" https://www.ncbi.nlm.nih.gov/pubmed/29059459 "Original article," "Expression of cytochrome P450 regulators in cynomolgus macaque. " "Uno, Y. and Yamazaki, H. " Xenobiotica 48 695-703 2018 "doi: 10.1080/00498254.2017.1363928" https://www.ncbi.nlm.nih.gov/pubmed/28812950 "Original article," "Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. " "Nakanishi, K., Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. " Xenobiotica 48 757-763 2018 10.1080/00498254.2017.1363444 https://www.ncbi.nlm.nih.gov/pubmed/28762864 "Original article," "Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol, and midazolam in common marmosets genotyped for cytochrome P450 2C19." "Toda, A., Uehara, S., Inoue, T., Utoh, M., Kusama, T., Shimizu, M., Uno, Y., Mogi, M., Sasaki, E., and Yamazaki, H. " Xenobiotica 48 720-726 2018 10.1080/00498254.2017.1353716 https://www.ncbi.nlm.nih.gov/pubmed/28686070 "Original article, " "Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates.." "Uehara, S., Uno, Y., Oshio, T., Inoue, T., Sasaki, E., and Yamazaki, H" Xenobiotica 48 656-662 2018 10.1080/00498254.2017.1354138 https://www.ncbi.nlm.nih.gov/pubmed/28689458 "Original article," " Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques." "Uno, Y., Osada, N., Sakurai, S., Shimozawa, N., Iwata, T., Ikeo, K., and Yamazaki, H." J.Vet.Pharmacol.Ther., 41 e30-e34 2018 "doi: 10.1111/jvp.12443" https://www.ncbi.nlm.nih.gov/pubmed/28752932 "Original article," "Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and ffve CYP2A13 allelic variants" "Shimada, T., Murayama, N., Kakimoto, K., Takenaka, T., Lim, Y.-R., Yeom, S., Kim, D., Yamazaki, H., Guengerich, F. P., and Komori, M. " Xenobiotica 48 565-575 2018 10.1080/00498254.2017.1347306 https://www.ncbi.nlm.nih.gov/pubmed/28648140 "Original article," "Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines. " "Uehara, S., Yuki, Y., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H." Xenobiotica 48 342-347 2018 10.1080/00498254.2017.1321811 https://www.ncbi.nlm.nih.gov/pubmed/28196829 "Original article," "R-Warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys" "Utoh, M., Kusama, T., Miura, T., Mitsui, M., Kawano, M., Hirano, T., Shimizu, M., Uno, Y., and Yamazaki, H." Xenobiotica 48 206-210 2018 DOI:10.1080/00498254.2017.1288945 https://www.ncbi.nlm.nih.gov/pubmed/28136132 "Original article," "Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice" "Yamazaki-Nishioka, M., Shimizu, M., Suemizu, H., Nishiwaki, M., Mitsui, M., and Yamazaki, H. " Xenobiotica 48 117-123 2018 DOI:10.1080/00498254.2017.1288280 https://www.ncbi.nlm.nih.gov/pubmed/28145791 Review "Meet Our Editorial Board Member" "Hiroshi Yamazaki" "Drug Metabolism Letters" 11 1 2017 10.2174/187231281101171117161332 "Review article," "Differences in toxicological and pharmacological responses mediated by polymorphic cytochromes P450 and related drug-metabolizing enzymes." "Yamazaki, H." "Chem. Res. Toxicol." 30 53-60 2017 10.1021/acs.chemrestox.6b00286 https://www.ncbi.nlm.nih.gov/pubmed/?term=27750412 "Correction, " "Correction to “Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1”" "Uehara S., Uno Y., Inoue T., Sasaki E., and Yamazaki H" "Drug Metab.Dispos." 45 956 2017 https://doi.org/10.1124/dmd.115.067561err "Corrigendum, " "Corrigendum to ""Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9"" [Drug Metab Pharmacokinet 30 (2015) 130-132]" "Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H. " "Drug Metab.Pharmacokinet.," 32 192 2017 "Original article," "The dihydroxy metabolite of the teratogen thalidomide causes oxidative DNA damage" "Wani, T. H., Chakrabarty, A., Shibata, N., Yamazaki, H., Guengerich, F. P., and Chowdhury, G. " "Chem. Res. Toxicol." 30 1622-1628 2017 10.1021/acs.chemrestox.7b00127 "Original article," "Effects of meat intake frequency and polymorphic cytochrome P450 2A6 activity on individual colorectal tumour risk in a Japanese cohort." "Yamazaki, H., Fujieda, M., Shimizu, M., Shiotani, A., SImabukuro, S., Mure, K., Takeshita, H., and Ishikawa, H. " "J.Cancer Ther." 8 645-652 2017 10.2131/jts.42.343 http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=77716 "Original article," "Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models" "Utoh, M., Miura, T., Kusama, T., Uehara, S., Shimizu, M., Uno, Y., and Yamazaki, H." "Biopharm. Drug Dispos.," 38 439-442 2017 10.1002/bdd.2084 https://www.ncbi.nlm.nih.gov/pubmed/28608515 "Original article," "Hepatic expression of cytochrome P450 enzymes in non-human primate species. " "Uehara, S., Uno, Y., and Yamazaki, H. " J.Med.Primatol. 46 347-351 2017 10.1111/jmp.12288 https://www.ncbi.nlm.nih.gov/pubmed/28664555 "Original article," "Regio- and stereo-selective oxidation of a cardiovascular drug metoprolol mediated by cytochrome P450 2D and 3A enzymes in marmoset livers" "Uehara, S., Ishii, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H" "Drug Metab. Dispos.," 45 896-899 2017 doi.org/10.1124/dmd.117.075630 https://www.ncbi.nlm.nih.gov/pubmed/28495902 "Original article," "Molecular cloning and characterization of marmoset aldehyde oxidase" "Uehara, S., Uno, Y., Okamoto, E., Inoue, T., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos" 45 883-886 2017 doi.org/10.1124/dmd.117.076042 https://www.ncbi.nlm.nih.gov/pubmed/28487309 "Original article," "Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model" "Shimizu, M. and Yamazaki, H. " "J.Toxicol. Sci." 42 485-490 2017 "Original article," "Functional characterization and tissue expression of marmoset cytochrome P450 2E1 " "Uehara, S., Uno, Y., Tomioka, E., Inoue, T., Sasaki, E., and Yamazaki, H. " "Biopharm. Drug Dispos.," 38 394-397 2017 "Original article," "Ratio of serum levels of AGEs to soluble RAGE Is correlated with trimethylamine-N-oxide in non-diabetic subjects." "Tahara, N., Yamagishi, S., Tahara, A., Honda, A., Igata, S., Bekki, M., Nakamura, T., Sugiyama, Y., Takeuchi, M., Shimizu, M., Yamazaki, H., Fukami, K., and Fukumoto, Y. " " Int.J.Food Sci.Nutr." 68 013-1020 2017 10.1080/09637486.2017.1318117 https://www.ncbi.nlm.nih.gov/pubmed/28434257 "Original article," "Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity." "Murayama, N., Kazuki, Y., Satoh, D., Arata, K., Harada, T., Shibata, N., Guengerich, F. P., and Yamazaki, H." "J. Toxicol. Sci." 42 343-348 2017 10.2131/jts.42.343 https://www.ncbi.nlm.nih.gov/pubmed/28496040 "Original article," "Marmoset flavin-containing monooxygenase 3 in liver is a major benzydamine and sulindac sulfide oxygenase. " "Uehara, S., Shiimizu, M., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H." "Drug Metab. Dispos." 45 497-500, 2017 doi.org/10.1124/dmd.117.075184 https://www.ncbi.nlm.nih.gov/pubmed/28258069 "Original article," "Marmoset cytochrome P450 3A4 orthologue expressed in liver and small intestine tissues efficiently metabolizes midazolam, alprazolam, nifedipine, and testosterone" "Uehara, S., Uno, Y., Nakanishi, K., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H. " "Drug Metab.Dispos." 45 457-467 2017 doi.org/10.1124/dmd.116.074898 https://www.ncbi.nlm.nih.gov/pubmed/28196829 "Original article," "Characterization of microminipig as an in vivo experimental model for cardiac safety pharmacology" "Matsukura, S., Nakamura, Y., Cao, X., Wada, T., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama, A. " J.Pharmacol.Sci. 133 103-109 2017 "doi: 10.1016/j.jphs.2017.02.002" https://www.ncbi.nlm.nih.gov/pubmed/28245963 "Original article," "Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice." "Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H." Xenobiotica 47 844-848 2017 "DOI: 10.1080/00498254.2016.1247218" https://www.ncbi.nlm.nih.gov/pubmed/27852146 "Original article, " "Cloning and expression of a novel catechol-O-methyltransferase in common marmosets." "Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H." " J.Vet.Med.Sci." 79 267-272 2017 "DOI: 10.1292/jvms.16-0459" https://www.ncbi.nlm.nih.gov/pubmed/27890888 "Perspective, " "Differences in toxicological and pharmacological responses mediated by polymorphic cytochromes P450 and related drug-metabolizing enzymes" "Yamazaki, H." "Chem. Res. Toxicol." 30 53-60 2017 10.1021/acs.chemrestox.6b00286 www.ncbi.nlm.nih.gov/pubmed/27750412 "Original article, " "Sex- and age-dependent gene expression in human liver: an implication for drug-metabolizing enzymes." "Uno, Y., Takata, R., Kito, G., Yamazaki, H., Nakagawa, K., Nakamura, Y., Kamataki, T., and Katagiri, T. " "Drug Metab. Pharmacokinet." 32 100-107 2017 10.1016/j.dmpk.2016.10.409 https://www.ncbi.nlm.nih.gov/pubmed/28153492 "Original article, " "CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: the potential role of CYP2C76 in early embryogenesis" "Koyama, S., Fukuda, K., Watanabe, S., Matsushita, A., Tsuchiya, H., Fujinami, N., Hohara, S., Murayama, N., Nagano, M., Yamazaki, H., Fukuzaki, K., Uno, Y., and Hosoi, Y." "Drug Metab. Pharmacokinet." 32 112-115 2017 10.1016/j.dmpk.2016.10.411 https://www.ncbi.nlm.nih.gov/pubmed/28153493 "Original article, " "Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling" "Kamimura, H., Ito, S., Chijiwa, H., Okuzono, T., Ishiguro, T., Yamamoto, Y., Nishinoaki, S., Mitsui, M., Kalgutkar, A. S., Ninomiya, S., Yamazaki, H., and Suemizu, H." Xenobiotica 47 382-393 2017 10.1080/00498254.2016.1199063 http://www.ncbi.nlm.nih.gov/pubmed/27389028 "Original article, " "Stable and episodic/bolus patterns of methylmercury exposure on mercury accumulation and histopathologic alterations in the nervous system" "Sakamoto, M., Kakita, A., Domingo, J. L., Yamazaki, H., Oliveira, R. B., Sarrazin, S., Eto, K., and Murata, K." Environ.Res. 152 446-453 2017 10.1016/j.envres.2016.06.034 https://www.ncbi.nlm.nih.gov/pubmed/27450633 "Original article, " "Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid omega-hydroxylase expressed in liver and kidney tissues" "Uehara, S., Uno, Y., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H." Xenobiotica 47 553-561 2017 DOI:10.1080/00498254.2016.1206673 "Original article, " "Cytochrome P450 2A6 phenotyping using dietary caffeine salivary metabolite ratios and genotyping using blood on storage cards in non-smoking Japanese volunteers" "Murayama, N., Shimizu, M., Kobayashi, K., Kishimoto, I., and Yamazaki, H. " "Drug Metab.Lett., " 10 240-243 2016 10.2174/1872312810666161114144008 https://www.ncbi.nlm.nih.gov/pubmed/27842485 Review, "Upholding science in health, safety and environmental risk assessments and regulations" "Aschner, M., Autrup, H. N., Berry, S. C., Boobis, A. R., Cohen, S. M., Creppy, E. E., Dekant, W., Doull, J., alli, C. L., Goodman, J. I., Gori, G. B., Greim, H. A., Joudrier, P., Kaminski, N. E., Klaassen, C. D., Klaunig, J. E., Lotti, M., Marquardt, H. W. J., Pelkonen, O., Sipes, I. G., Wallace, K., and Yamazaki, H" Toxicology 371 12-16 2016 http://dx.doi.org/10.1016/j.tox.2016.09.005 Review, "Whither the impending european regulation of presumed endocrine disruptors?" "Autrup, H. N., Berry, S. C. L., Cohen, S. M., Creppy, E. E., de Camargo, J. L., Dekant, W., Dietrich, D., Galli, C. L., Goodman, J. I., Gori, G. B., Greim, H. A., Klaunig, J. E., Lotti, M., Marquardt, H. W., Wallace, K. B., and Yamazaki, H. " "Regul. Toxicol. Pharmacol." 82 A1-A2 2016 10.1016/j.yrtph.2016.09.006 "Original article, " "Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets" "Uehara, S., Kawano, M., Murayama, N., Uno, Y., Utoh, M., Inoue, T., Sasaki, E., and Yamazaki, H. " " Biochem. Pharmacol" 120 56-62 2016 "doi: 10.1016/j.bcp.2016.09.010." http://www.ncbi.nlm.nih.gov/pubmed/27641812 "Original article, " "Roles of human CYP2A6 and monkey CYP2A24 and 2A26 cytochrome P450 enzymes in the oxidation of 2,5,2',5'-tetrachlorobiphenyl" "Shimada, T., Kakimoto, K., Takenaka, S., Koga, N., Uehara, S., Murayama, N., Yamazaki, H., Kim, D., Guengerich, F. P., and Komori, M." "Drug Metab. Dispos" 44 1899-1909 2016 dx.doi.org/10.1124/dmd.115.063909. "Original article" "Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules" "Mori, K., Saito, R., Nakamaru, Y., Shimizu, M., and Yamazaki, H." " Biopharm. Drug Dispos., " 37 491–506 2016 10.1002/bdd.2021 https://www.ncbi.nlm.nih.gov/pubmed/27604638 "Original article, " "Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide" "Takahashi, T., Ohtsuki, Y., Uno, Y., Utoh, M., Yamazaki, H., and Kume, T. " "Biopharm. Drug Dispos." 37 479-490 2016 10.1002/bdd.2039. https://www.ncbi.nlm.nih.gov/pubmed/27603548 "Original article, " "Assessment of protein binding of 5-hydroxythalidomide bioactivated in humanized mice with human P450 3A-chromosome or hepatocytes by two-dimensional electrophoresis/accelerator mass spectrometry" "Yamazaki, H., Suemizu, H., Kazuki, Y., Oofusa, K., Kuribayashi, S., Shimizu, M., Ninomiya, S., Horie, T., Shibata, N., and Guengerich, F. P" "Chem. Res. Toxicol." 29 1279-1281 2016 10.1021/acs.chemrestox.6b00210 http://www.ncbi.nlm.nih.gov/pubmed/27464947 "Original article, " "Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H" "Biopharm. Drug Dispos." 37 310-313 2016 10.1002/bdd.1998 http://www.ncbi.nlm.nih.gov/pubmed/26581561 "Review, " "Combining Chimeric mice with humanized liver, mass spectrometry, and physiologically-based pharmacokinetic modeling in toxicology. " "Yamazaki, H., Suemizu, H., Mitsui, M., Shimizu, M., and Guengerich, F. P. " "Chem. Res. Toxicol." 29 1903-1911 2016 10.1021/acs.chemrestox.6b00136 http://www.ncbi.nlm.nih.gov/pubmed/27337115 "Review, " "Utility of non-human primates in drug development: comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes" "Uno, Y., Uehara, S., and Yamazaki, H. " "Biochem. Pharmacol." 121 1-7 2016 10.1016/j.bcp.2016.06.008 http://www.ncbi.nlm.nih.gov/pubmed/27318253 "Original article, " "Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes" "Higuchi, Y., Kawai, K., Kanai, T., Yamazaki, H., Chesne, C., Guguen-Guillouzo, C., and Suemizu, H. " Hepatol.Res. 46 1045-1057 2016 10.1111/hepr.12644 http://www.ncbi.nlm.nih.gov/pubmed/26724677 "Original article, " "Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine" "Uehara, S., Uno, Y., Inoue, T., Okamoto, E., Sasaki, E., and Yamazaki, H. " Xenobiotica 46 977-985 2016 10.3109/00498254.2016.1146366 http://www.ncbi.nlm.nih.gov/pubmed/26899760 "Original article, " " Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling" "Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H." Xenobiotica 46 1049-1055 2016 10.3109/00498254.2016.1147102 http://www.ncbi.nlm.nih.gov/pubmed/26916082 "Original article, " "Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing" "Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y." "Biopharm. Drug Dispos." 37 220-232 2016 10.1002/bdd.2007 http://www.ncbi.nlm.nih.gov/pubmed/27214158 "Original article, " "Individual differences in metabolic clearance of S-warfarin efficiently mediated by polymorphic marmoset cytochrome P450 2C19 in livers. " "Uehara, S., Uno, Y., Inoue, T., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 44 911-915 2016 10.1124/dmd.116.070383 http://www.ncbi.nlm.nih.gov/pubmed/27098744 "Original article, " "Structure-function studies of naphthalene, phenanthrene, biphenyl, and their alkynyl derivatives in interaction with and oxidation by cytochromes P450 2A13 and 2A6" "Shimada, T., Takenaka, S., Kakimoto, K., Murayama, N., Lim, Y.-R., Kim, D., Foroozesh, M., Yamazaki, H., Guengerich, F. P., and Komori, M. " "Chem. Res. Toxicol." 29 1029-1040 2016 10.1021/acs.chemrestox.6b00083 http://www.ncbi.nlm.nih.gov/pubmed/27137136 "Original article, " "A case of delayed emergence following propofol anesthesia: genetic analysis" "Yonekura, H., Murayama, N., Yamazaki, H., and Sobeu, K." "Anesth.Analg.Case Rep." 7 243-246 2016 10.1213/XAA.0000000000000397 https://www.ncbi.nlm.nih.gov/pubmed/27749294 "Original article, " "Systematic approach to optimize a pretreatment method for ultrasensitive LC/MS/MS analysis of multiple target compounds in biological samples" "Togashi, K., Mutaguchi, K., Kumuro, S., Kataoka, M., Yamazaki, H., and Yamashita, S. " J.Sep.Sci. 39 3212-3220 2016 10.1002/jssc.201600282 http://www.ncbi.nlm.nih.gov/pubmed/27346708 "Original article," "In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9" "Iwasaki, K., Kitsugi, Y., Ikeda, K., Yoshikawa, T., Hosaka, S., Uehara, S., Uno, Y., Utoh, M., and Yamazaki, H." "Biopharm. Drug Dispos." 37 379-383 2016 10.1002/bdd.2021 http://www.ncbi.nlm.nih.gov/pubmed/27417918 原著論文 "Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells" "Sugiyama, I., Murayama, N., Kuroki, A., Kota, J., Iwano, S., Yamazaki, H., and Hirota, T" Xenobiotica 46 765-774 2016 10.3109/00498254.2015.1118774 http://www.ncbi.nlm.nih.gov/pubmed/26711482 原著論文 "Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling" "Shida, S. and Yamazaki, H" Xenobiotica 46 759-764 2016 10.3109/00498254.2015.1118650 http://www.ncbi.nlm.nih.gov/pubmed/26652678 原著論文 "Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing." "Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. " "Biopharm. Drug Dispos." 37 220-232 2016 10.1002/bdd.2007 http://www.ncbi.nlm.nih.gov/pubmed/27214158 原著論文 "Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. " "Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. " Gastroenterology 150 1171-1182 2016 10.1053/j.gastro.2016.01.035 http://www.ncbi.nlm.nih.gov/pubmed/26873401 原著論文 "A new marmoset P450 4F12 enzyme expressed in small intestines and livers efficiently metabolizes an anti-histaminic drug ebastine. " "Uehara, S., Uno, Y., Yuki, Y., Inoue, T., Sasaki, E., and Yamazaki, H." "Drug Metab. Dispos." 44 833-841 2016 10.1124/dmd.116.070367 http://www.ncbi.nlm.nih.gov/pubmed/27044800 原著論文 "Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. " "Kazuki, Y., Akita, M., Kobayashi, K., Osaki, M., Satoh, D., Abe, S., Takehara, S., Kazuki, K., Yamazaki, H., Kamataki, T., and Oshimura, M. " Sci.Rep. 6 21419 2016 10.1038/srep21419 http://www.ncbi.nlm.nih.gov/pubmed/26903378 原著論文 "Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5. Hum." "Okubo, M., Morita, S., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. " Hum.Psychopharmacol.Clin.Exp. 31 93-102 2016 10.1002/hup.2516 http://www.ncbi.nlm.nih.gov/pubmed/26856541 原著論文 "Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P450 2D6 and flavin-containing monooxygenase 3. Hum." "Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. " Hum.Psychopharmacol.Clin.Exp. 31 83-92 2016 10.1002/hup.2515 http://www.ncbi.nlm.nih.gov/pubmed/26856397 原著論文 "Molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome P450 1A1, 1A2, and 1B1." "Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 44 8-15 2016 10.1124/dmd.115.067561 http://www.ncbi.nlm.nih.gov/pubmed/26502772 原著論文 "Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. " "Uehara, S., Uno, Y., Inoue, T., Suzuki, T., Utoh, M., Sasaki, E., and Yamazaki, H." Xenobiotica 46 573-578 2016 10.3109/00498254.2015.1096980 http://www.ncbi.nlm.nih.gov/pubmed/26503341 原著論文 "In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans. " "Sekiguchi, K., Kanazu, T., Murayama, N., Yamazaki, H., and Yamaguchi, T." Xenobiotica 46 495-502 2016 10.3109/00498254.2015.1091114 http://www.ncbi.nlm.nih.gov/pubmed/26677906 原著論文 "Development of a genotyping tool for a functionally relevant CYP2C19 allele (Phe100Asn, Ala103Val, Ile112Leu) in cynomolgus macaques." "Uno, Y., Yamazaki, H." J.Vet.Med.Sci. 78 147-148 2016 原著論文 "Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). " "Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. " Xenobiotica 46 163-168 2016 10.3109/00498254.2015 http://www.ncbi.nlm.nih.gov/pubmed/26114209 原著論文 "Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene by human cytochrome P450 2A13. " "Shimada, T., Takenaka, S., Murayama, N., Kramlinger, V. M., Kim, J.-H., Kim, D., Foroozesh, M. K., Yamazaki, H., Guengerich, F. P., and Komori, M." Xenobiotica 46 " 211-224" 2016 10.3109/00498254.2015.1069419 http://www.ncbi.nlm.nih.gov/pubmed/26247835 "Original article," " Strong induction of cytochrome P450 1A/3A, but not P450 2B, in cultured hepatocytes from common marmosets and cynomolgus monkeys by typical human P450 inducing agents" "Uehara,S., Uno,Y., Suzuki,T., Inoue,S., Utoh,M., Sasaki,E., and Yamazaki,H." "Drug Metab.Lett." 10 244-253 2016. "10.2174/1872312810666161114144412 " https://www.ncbi.nlm.nih.gov/pubmed/27842484 総説 "Meet our editorial board member" "Yamazaki, H." "Curr.Drug Metab." 16 333 2015 総説 "19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告" 山崎浩史、清水万紀子 薬剤学 75 380 2015 総説 "Regioselective hydroxylation of steroid hormones by human cytochromes P450." " Niwa, T., Murayama, N., Imagawa, Y., and Yamazaki, H." "Drug Metab. Rev." 47 89-110 2015 原著論文 "Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. " "Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H." Mol.Genet.Metab.Report 5 89-93 2015 原著論文 "Simulation of human plasma concentrations of thalidomide and primary 5-hydroxylated metabolites explored with pharmacokinetic data in humanized TK-NOG mice. " "Nishiyama, S., Suemizu, H., Shibata, N., Guengerich, F. P., and Yamazaki, H. " "Chem. Res.Toxicol." 28 2088-2090 2015 10.1021/acs.chemrestox.5b00381 http://www.ncbi.nlm.nih.gov/pubmed/26492539 原著論文 "Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms." "Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H." "Data in Brief" 5 642-645 2015 10.1016/j.dib.2015.10.019 http://www.ncbi.nlm.nih.gov/pubmed/26958620 原著論文 "Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances." "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H." "Biopharm. Drug Dispos." 36 636-643 2015 原著論文 "Point mutation of cytochrome P450 2A6 (a polymorphic allele CYP2A6.25) confers new substrate specificity towards flavonoids. " "Uno, T., Ogura, C., Izumi, C., Nakamura, M., Yanase, T., Yamazaki, H., Ashida, H., Kanamar, K., Yamagata, H., and Imaishi, H. " "Biopharm. Drug Dispos" 36 552-563 2015 原著論文 "Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole." "Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 43 1408-1416 2015 "doi: 10.1124/dmd.115.066100." http://www.ncbi.nlm.nih.gov/pubmed/26228688 原著論文 動物データに基づくヒト放射線内部被曝線量の評価-薬物動態学的方法論の応用- "杉本倫教, 岩瀬由未子,弓田長彦,千葉康司,山崎浩史,池田敏彦. " Radioisotopes 64 673-679 2015 原著論文 "Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. " "Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. " Radioisotopes 64 509-519 2015 原著論文 "Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 1119-1122 2015 原著論文 "Substrate selectivities and catalytic activities of marmoset liver cytochrome P450 2A6 differed from those of human P450 2A6." "Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H." "Drug Metab. Dispos." 43 " 969-976" 2015 "doi: 10.1124/dmd.115.063909" http://www.ncbi.nlm.nih.gov/pubmed/25858611 原著論文 "Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling." "Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H." Regul.Toxicol.Pharmacol. 72 " 71-76" 2015 原著論文 "Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. " "Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 95 110-114 2015 原著論文 "Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling." "Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H." Xenobiotica 45 881-886 2015 原著論文 "Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). " "Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos. " 43 735-742 2015 "doi: 10.1124/dmd.115.063594." http://www.ncbi.nlm.nih.gov/pubmed/25735838 原著論文 "Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling." "Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H." "Environ. Toxicol. Pharmacol." 39 1067-1073 2015 原著論文 "Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan." "Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. " Xenobiotica 45 766-772 2015 http://dx.doi.org/10.3109/00498254.2015.1019595 https://www.ncbi.nlm.nih.gov/pubmed/25801057 原著論文 "CYP2D44 polymorphisms in cynomolgus and rhesus macaques." "Uno, Y., Uehara, S., Kohara, S., Osada, N., Murayama, N., and Yamazaki,H." Mol.Biol.Rep. 42 1149–1155 2015 原著論文 "Oxidation of acenaphthene and acenaphthylene by human cytochrome P450 enzymes." "Shimada, T., Takenaka, S., Murayama, N., Yamazaki, H., Kim, J. H., Kim, D., Yoshimoto, F. K., Guengerich, F. P., and Komori, M." "Chem. Res.Toxicol." 28 " 268-278" 2015 "DOI: 10.1021/tx500505y" http://www.ncbi.nlm.nih.gov/pubmed/25642975 原著論文 "Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays." "Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H." "Drug Metab.Lett." 9 3-7 2015 http://www.ncbi.nlm.nih.gov/pubmed/25600204 原著論文 "Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. " "Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H." "Biopharm. Drug Dispos." 36 148-162 2015 原著論文 "Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. " "Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S." J.Cardiovasc.Pharmacol. 65 " 289-295" 2015 原著論文 "A. Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models. " "Watanabe, Y., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Murayama, N., Sugiyama, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama" "Basic Clin.Pharmacol.Toxicol." 116 468-475 2015 原著論文 "A. Azithromycin can prolong QT interval and suppress ventricular contraction, but will not induce Torsade de Pointes. " "Ohara, H., Nakamura, Y., Watanabe, Y., Cao, X., Yamazaki, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Yamazaki, J., Ikeda, T., and Sugiyama" Cardiovasc.Toxicol. 15 232-240 2015 原著論文 "Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole, and metoprolol, in cynomolgus monkeys using in vitro-in vivo correlation." "Koyanagi, T., Nakanishi, Y., Murayama, N., Yamaura, Y., Ikeda, K., Yano, K., Uehara, S., Utoh, M., Kim, S., Uno, Y., and Yamazaki, H." Xenobiotica 45 312-321 2015 原著論文 "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9. " "Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 130-132 2015 原著論文 "Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans." "Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. " "Drug Metab.Pharmacokinet." 30 64-69 2015 原著論文 "Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers." "Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 " 70-74" 2015 原著論文 "Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes." "Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H." "Clinica Chimica Acta." 441 71-74 2015 原著論文 "Immunochemical quantification of cynomolgus CYP2J2, CYP4A, and CYP4F enzymes in liver and small intestine." "Uehara, S., Murayama, N., Nakanshi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y." " Xenobiotica" 45 124-130 2015 原著論文 "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." "Okubo, M., Murayama, N., Miura, J., Chiba, Y., and Yamazaki, H." "Biochem. Pharmacol." 93 104-109 2015 原著論文 "Fluvoxamine by itself has potential to directly induce long QT syndrome at supratherapeutic concentrations." "Yamazaki-Hashimoto, Y., Nakamura, Y., Ohara, H., Cao, X., Kitahara, K., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Ikeda, T., Yamazaki, J., and Sugiyama, A." "J. Toxicol. Sci." 40 33-42 2015 原著論文 "Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase." "Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 27-33 2015 "doi: 10.1124/dmd.114.061275" http://www.ncbi.nlm.nih.gov/pubmed/25318994 原著論文 "Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver." "Yamazaki, H., Kuribayashi, S., Inoue, T., Honda, T., Tateno, C., Oofusa, K., Ninomiya, S., Ikeda, T., Izumi, T., and Horie, T." Toxicol.Res. 4 106-111 2015 総説 "Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450." "Niwa, T., Inagawa, Y., and Yamazaki, H." "Curr.Drug Metab." 15 651-678 2014 総説 平成26年度日本薬物動態学会学会賞を受賞して 山崎浩史 "Drug Metab.Pharmacokinet." 29(6) 15-17 2014 総説 私立薬大での薬物動態学研究室の立ち上げ(2) 山崎浩史 "Drug Metab.Pharmacokinet." 29(6) 39-42 2014 総説 私立薬大での薬物動態学研究室の立ち上げ(1) 山崎浩史 "Drug Metab.Pharmacokinet." 29(5) 21-24 2014 総説 "Drug-induced liver toxicity studies: research into human metabolites clarifies their role in drug development. " "Yamazaki, H. " "Drug Metab.Pharmacokinet." 29 111 2014 原著論文 "Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans." "Sakai, C., Iwano, S., Yamazaki, Y., Ando, Y., Nakane, F., Kouno, M., Yamazaki, H., and Miyamoto, Y. " "J. Drug Metab.Toxicol." 5 173 2014 原著論文 "Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1, and CYP51A1 in cynomolgus macaques. " "Uno, Y., Hosaka, S., and Yamazaki, H." J.Vet.Med.Sci. 76 1647-1650 2014 原著論文 "Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation." "Niwa T, Yasumura M, Murayama N and Yamazaki H." "Drug Metab.Lett." 8 43-50 2014 原著論文 "Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. " "Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H." Regul.Toxicol.Pharmacol. 70 468-473 2014 原著論文 "CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. " "Uno, Y., Matsushita, A., Shukuya, M., Matsumoto, Y., Murayama, N., and Yamazaki, H. " "Biochem. Pharmacol." 91 " 242-248" 2014 原著論文 "Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism." "Uno, Y., Uehara, S., Kohara, S., Murayama, N., and Yamazaki, H." "Drug Metab. Dispos." 42 1407-1410 2014 "doi: 10.1124/dmd.114.059220." http://www.ncbi.nlm.nih.gov/pubmed/24985704 原著論文 "Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. " "Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H." "Regul.Toxicol.Pharmacol. " 70 214-221 2014 原著論文 "Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing." "Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H." "PLoS One" 9 e100936 2014 原著論文 "Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs." "Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 90 159-165 2014 原著論文 "Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. " "Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H." "Clin.Kidney J." 7 329 2014 原著論文 "A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)" "Ohyama, K., Shimizu, M., and Yamazaki, H." "Jpn. J. Pharm. Health Care Sci." 40 310-316 2014 原著論文 "K. Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 Inhibitor teneligliptin: an open-label study in healthy white subjects in Germany." "Nakamaru, Y., Hayashi, Y., Sekine, M., Kinoshita, S., Thompson, J., Kawaguchi, A., Davies, M., Jurgen, Heuer H., Yamazaki, H., and Akimoto" Clin.Ther. 36 760-769 2014 原著論文 "Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig. Biopharm." "Higashi, E., Ando, A., Iwano, S., Murayama, N., Yamazaki, H., and Miyamoto, S. " "Drug Dispos." 35 313-320 2014 原著論文 "Koyanagi, T., Yamaura, K., Yano, K., Kim, S., and Yamazaki, H. " "Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs." Xenobiotica 44 893-901 2014 原著論文 "Yajima, K., Uno, Y., Murayama, N., Uehara, S., Shimizu, M., Nakamura, C., Iwasaki, K., Utoh, M., and Yamazaki, H." "Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. " "Drug Metab. Dispos" 42 867-871 2014 原著論文 "Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys." "Uehara, S., Murayama, N., Nakanishi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y." Xenobiotica 44 769-774 2014 原著論文 "Voriconazole metabolism, toxicity and the effect of cytochrome P450 2C19 genotype. " "Zonios, D., Yamazaki, H., Murayama, N., Natrarajan, V., Palmore, T., Childs, R., Skinner, J., and Bennett, J." J.Infect.Dis. 209 1941-1948 2014 "doi: 10.1093/infdis/jiu017" http://www.ncbi.nlm.nih.gov/pubmed/24403552 原著論文 "Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population." "Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R." "Brit.J. Clin. Pharmacol." 77 839-851 2014 原著論文 "Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor." "Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H." "Chem. Res.Toxicol." 27 304-308 2014 "doi: 10.1021/tx4004374." http://www.ncbi.nlm.nih.gov/pubmed/24460184 原著論文 "Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans." "264. Nakamaru, Y., Hayashi, Y., Ikegawa, R., Kinoshita, S., Madera, B. P., Gunput, D., Kawaguchi, A., Davies, M., Mair, S., Yamazaki, H., Kume, T., and Suzuki, M." Xenobiotica 44 242-253 2014 原著論文 "Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. " "Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H." Xenobiotica 44 10-16 2014 原著論文 "Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analog of thalidomide." "Chowdhury G, Shibata N, Yamazaki H., and Guengerich FP." "Chem. Res.Toxicol." 27 147-156 2014 10.1021/tx4004215 原著論文 "The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice." "Higuchi, Y., Kawai, K., Yamazaki, H., Nakamura, M., Bree, F., Guillouzo, C., and Suemizu, H. " Xenobiotica 44 146-153 2014 "Original article, " " Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes" "Uno Y, Murayama N, Yamazaki H.." "Drug Metab and Pharmacokinet," 35 341-343 2000 10.1016/j.dmpk.2020.02.001 "Original article, " "Systematic characterization of glutathione S-transferases in common marmosets" "Uno Y, Uehara S, Tanaka S, Murayama N, and Yamazaki H. " "Biochem Pharmacol " 174 113835 2000 10.1016/j.bcp.2020.113835 https://www.ncbi.nlm.nih.gov/pubmed/32027883 "Original article, " "Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity" "Kamiya, Y., Takaku, H., Yamada, R., Akase, C., Abe, Y., Sekiguchi, Y., Murayama, N., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H. " "Toxicol. Rep." 7 149-154 2000 10.1016/j.toxrep.2020.01.004 "Original article, " "Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques" "Uno, Y., and Yamazaki, H. " "Drug Metab Pharmacokinet" 42 100431 " 2022." 10.1016/j.dmpk.2021.100431 https://www.ncbi.nlm.nih.gov/pubmed/34974333