種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs" "Shimizu, M.; Nii, A.; Uno, Y.; Yamazaki, H." "Drug Metab Dispos" 53 100140 2025 原著論文 "Virtual hepatic and plasma exposure of voriconazole administered to cytochrome P450 2C19 poor metabolizers as possible causal factor for hepatic disorder in Japanese database predicted by simplified and full pharmacokinetic modeling systems" "Adachi, K.; Ohyama, K.; Shimura, Y.; Tanaka, Y.; Shimizu, M.; Saito, Y.; Yamazaki, H." "Biol Pharm Bull" 48 1271-1276 2025 原著論文 "In silico estimation for binary classification of unaffected and impaired catalytic function of flavin-containing monooxygenase 3 (FMO3) variants and in vitro validation in an updating of Japanese genome resource database" "Shimizu, M.; Hishinuma, E.; Igarashi, R.; Saito, S.; Makiguchi, M.; Hiratsuka, M.; Yamazaki, H." "Biol Pharm Bull" 48 1062-1069 2025 原著論文 "Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies" "Tanaka, Y.; Shimizu, M.; Saito, Y.; Yamazaki, H." "Drug Metab Pharmacokinet" 62 101496 2025 原著論文 "Reported liver toxicity of food chemicals in rats extrapolated to humans using virtual human-to-rat hepatic concentration ratios generated by pharmacokinetic modeling with machine learning-derived parameters" "Adachi, K.; Hosoi, M.; Shimura, Y.; Shimizu, M.; Yamazaki, H." "J Toxicol Sci" 50 205-213 2025 原著論文 "Impact of variability of in silico and in vitro octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations" "Adachi, K.; Sasaki, T.; Arai, A.; Shimizu, M.; Yamazaki, H." "J Toxicol Sci" 49 459-466 2024 原著論文 "Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman" "Adachi, K.; Murata, M.; Inada, A.; Morimoto, T.; Shimizu, M.; Beppu, S.; Yamazaki, H." "Acute Med Surg" 11 e985 2024 原著論文 "Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs" "Shimizu, M.; Makiguchi, M.; Uno, Y.; Yamazaki, H." "Drug Metab Dispos" 52 906-910 2024 原著論文 "Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database" "Adachi, K.; Ohyama, K.; Tanaka, Y.; Murayama, N.; Shimizu, M.; Saito, Y.; Yamazaki, H." "Biol Pharm Bull" 47 1028-1032 2024 原著論文 "In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells" "Uehara, S.; Murayama, N.; Higuchi, Y.; Shimizu, M.; Suemizu, H.; Guengerich, F. P.; Yamazaki, H." "Chem Res Toxicol" 37 671-674 2024 原著論文 "Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances" "Adachi, K.; Shimizu, M.; Shono, F.; Funatsu, K.; Yamazaki, H." "J Toxicol Sci" 49 127-137 2024 原著論文 "Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database" "Adachi, K.; Ohyama, K.; Tanaka, Y.; Saito, Y.; Shimizu, M.; Yamazaki, H." "Biol Pharm Bull" 47 635-640 2024 原著論文 "Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources" "Shimizu, M.; Makiguchi, M.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 55 100539 2024 原著論文 "Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews" "Uno, Y.; Makiguchi, M.; Ushirozako, G.; Tsukiyama-Kohara, K.; Shimizu, M.; Yamazaki, H." "Comp Biochem Physiol C Toxicol Pharmacol" 277 109835 2024 原著論文 "Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6" "Shimizu, M.; Uehara, S.; Ohyama, K.; Nishimura, H.; Tanaka, Y.; Saito, Y.; Suemizu, H.; Yoshida, S.; Yamazaki, H." "Drug Metab Dispos" 52 35-43 2024 原著論文 "Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection" "Negishi, D.; Mitsumatsu, O.; Mitsumatsu, H.; Makiguchi, M.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 9 33 2023 原著論文 "Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank" "Shimizu, M.; Makiguchi, M.; Yokota, Y.; Shimamura, E.; Matsuta, M.; Nakamura, Y.; Harano, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 53 100528 2023 原著論文 "A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis - A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir" "Unita, R.; Adachi, K.; Inada, A.; Shimizu, M.; Beppu, S.; Yamazaki, H." "J Infect Chemother" 29 1068-1070 2023 原著論文 "Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in Silico Liver-to-Plasma Partition Coefficients" "Adachi, K.; Utsumi, M.; Sato, T.; Nakano, H.; Shimizu, M.; Yamazaki, H." "Biol Pharm Bull" 46 1316-1323 2023 原著論文 "Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in Silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats" "Adachi, K.; Nakano, H.; Sato, T.; Shimizu, M.; Yamazaki, H." "Biol Pharm Bull" 46 1133-1140 2023 原著論文 "Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database" "Adachi, K.; Ohyama, K.; Tanaka, Y.; Nakano, H.; Sato, T.; Murayama, N.; Shimizu, M.; Saito, Y.; Yamazaki, H." "Biol Pharm Bull" 46 856-863 2023 原著論文 "Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources" "Makiguchi, M.; Shimizu, M.; Yokota, Y.; Shimamura, E.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H." "Drug Metab Dispos" 51 884-891 2023 原著論文 "Roles of human cytochrome P450 3A4/5 in dexamethasone 6beta-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin" "Uehara, S.; Shimizu, M.; Suemizu, H.; Yamazaki, H." "Drug Metab Pharmacokinet" 50 100504 2023 原著論文 "A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria" "Shimizu, M.; Yamamoto, A.; Makiguchi, M.; Shimamura, E.; Yokota, Y.; Harano, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 50 100490 2023 原著論文 "High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4 *16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database" "Adachi, K.; Ohyama, K.; Tanaka, Y.; Sato, T.; Murayama, N.; Shimizu, M.; Saito, Y.; Yamazaki, H." "Drug Metab Pharmacokinet" 49 100486 2023 原著論文 "Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models" "Miura, T.; Uehara, S.; Shimizu, M.; Suemizu, H.; Yamazaki, H." "J Toxicol Sci" 47 531-538 2022 原著論文 "Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans" "Adachi, K.; Shimizu, M.; Yamazaki, H." "Biol Pharm Bull" 45 1812-1817 2022 原著論文 "Updated in silico prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for estimating internal concentrations in rats" "Adachi, K.; Shimizu, M.; Yamazaki, H." "J Toxicol Sci" "J Toxicol Sci" 453-456 2022 原著論文 "Correction to An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats""""" "Kamiya, Y.; Handa, K.; Miura, T.; Ohori, J.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H." "Chem Res Toxicol" 35 1433 2022 原著論文 "Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria" "Shimizu, M.; Hirose, N.; Kato, M.; Sango, H.; Uenuma, Y.; Makiguchi, M.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 46 100465 2022 原著論文 "Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus" "Negishi, D.; Mitsumatsu, O.; Matsumura, T.; Mitsumatsu, H.; Makiguchi, M.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 8 16 2022 原著論文 "Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats" "Uno, Y.; Shimizu, M.; Ogawa, Y.; Makiguchi, M.; Kawaguchi, H.; Yamato, O.; Ishizuka, M.; Yamazaki, H." "Biochem Pharmacol" 202 115125 2022 原著論文 "Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals" "Shimizu, M.; Hayasaka, R.; Kamiya, Y.; Yamazaki, H." "Biol Pharm Bull" 45 1142-1157 2022 原著論文 "Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo" "Uehara, S.; Shimizu, M.; Ple, K.; Routier, S.; Yoneda, N.; Higuchi, Y.; Suemizu, H.; Yamazaki, H." "Drug Metab Pharmacokinet" 44 100453 2022 原著論文 "Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model" "Kamiya, Y.; Miura, T.; Kato, A.; Murayama, N.; Shimizu, M.; Yamazaki, H." "Drug Metab Bioanal Lett" 15 64-69 2022 原著論文 "Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals" "Kamiya, Y.; Handa, K.; Miura, T.; Ohori, J.; Kato, A.; Shimizu, M.; Kitajima, M.; Yamazaki, H." "Biol Pharm Bull" 45 124-128 2022 原著論文 "Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5'-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species" "Kuwagata, M.; Hasegawa, T.; Takashima, H.; Shimizu, M.; Kitajima, S.; Yamazaki, H." "J Toxicol Sci" 46 553-560 2021 原著論文 "Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice" "Miura, T.; Uehara, S.; Shimizu, M.; Murayama, N.; Suemizu, H.; Yamazaki, H." "J Toxicol Sci" 46 525-530 2021 原著論文 "An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats" "Kamiya, Y.; Handa, K.; Miura, T.; Ohori, J.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H." "Chem Res Toxicol" 34 2180-2183 2021 原著論文 "A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects" "Shimizu, M.; Mizugaki, A.; Koibuchi, N.; Sango, H.; Uenuma, Y.; Yamazaki, H." "Drug Metab Pharmacokinet" 41 100420 2021 原著論文 "Differences in Pharmacokinetics and Haematotoxicities of Aniline and Its Dimethyl Derivatives Orally Administered in Rats" "Miura, T.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Yamazaki, H." "Biol Pharm Bull" 44 1775-1780 2021 原著論文 "Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital" "Adachi, K.; Beppu, S.; Terashima, M.; Fukuda, T.; Tomizawa, J.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 7 36 2021 原著論文 "Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital" "Adachi, K.; Sugitani, Y.; Unita, R.; Yoshida, K.; Beppu, S.; Terashima, M.; Fujii, M.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 7 33 2021 原著論文 "Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model" "Yanagi, M.; Kamiya, Y.; Murayama, N.; Banju, K.; Shimizu, M.; Yamazaki, H." "J Toxicol Sci" 46 391-399 2021 原著論文 "Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes" "Taniguchi-Takizawa, T.; Kato, N.; Shimizu, M.; Kume, T.; Yamazaki, H." "Drug Metab Pharmacokinet" 40 100412 2021 原著論文 "Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital" "Adachi, K.; Beppu, S.; Terashima, M.; Kobari, W.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 7 32 2021 原著論文 "Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments" "Yamazaki, H.; Shimizu, M.; Otani, T.; Mizugaki, A.; Mure, K.; Suzuki, S.; Ishikawa, H." "J Pharm Health Care Sci" 7 26 2021 原著論文 "Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes" "Miura, T.; Uehara, S.; Shimizu, M.; Suemizu, H.; Yamazaki, H." "J Toxicol Sci" 46 311-317 2021 原著論文 "Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1" "Uehara, S.; Uno, Y.; Shimizu, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 39 100398 2021 原著論文 "Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam" "Emoto, C.; Shimizu, M.; Tanaka, T.; Yamazaki, H." "Drug Metab Pharmacokinet" 39 100394 2021 原著論文 "Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models" "Miura, T.; Kamiya, Y.; Uehara, S.; Murayama, N.; Shimizu, M.; Suemizu, H.; Yamazaki, H." Xenobiotica 51 636-642 2021 原著論文 "Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources" "Shimizu, M.; Koibuchi, N.; Mizugaki, A.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 38 100387 2021 原著論文 "Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants" "Taniguchi-Takizawa, T.; Kato, H.; Shimizu, M.; Yamazaki, H." "Curr Drug Metab" 22 208-214 2021 原著論文 "Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling" "Toda, A.; Shimizu, M.; Uehara, S.; Sasaki, T.; Miura, T.; Mogi, M.; Utoh, M.; Suemizu, H.; Yamazaki, H." Xenobiotica 51 316-323 2021 原著論文 "Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model" "Miura, T.; Uehara, S.; Shigeta, K.; Yoshizawa, M.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Suemizu, H.; Yamazaki, H." "Chem Res Toxicol" 34 522-528 2021 原著論文 "In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals" "Kamiya, Y.; Handa, K.; Miura, T.; Yanagi, M.; Shigeta, K.; Hina, S.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H." "Chem Res Toxicol" 34 507-513 2021 原著論文 "Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital" "Adachi, K.; Beppu, S.; Nishiyama, K.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 7 6 2021 原著論文 "In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice" "Shimizu, M.; Uehara, S.; Suemizu, H.; Yamazaki, H." "Drug Metab Pharmacokinet" 37 100369 2021 原著論文 "Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan" "Uraoka, M.; Shimizu, M.; Kuwajima, Y.; Mizugaki, A.; Yokoyama, H.; Mure, K.; Yamazaki, H." "Curr Drug Metab" 21 1161-1164 2020 原著論文 "Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential" "Miura, T.; Shimizu, M.; Uehara, S.; Yoshizawa, M.; Nakano, A.; Yanagi, M.; Kamiya, Y.; Murayama, N.; Suemizu, H.; Yamazaki, H." "Chem Res Toxicol" 33 3048-3053 2020 原著論文 "Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)" "Shimizu, M.; Uno, Y.; Utoh, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 35 571-573 2020 原著論文 "Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model" "Miura, T.; Kamiya, Y.; Hina, S.; Kobayashi, Y.; Murayama, N.; Shimizu, M.; Yamazaki, H." "J Toxicol Sci" 45 695-700 2020 原著論文 "Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital" "Adachi, K.; Tuchiya, J.; Beppu, S.; Nishiyama, K.; Shimizu, M.; Yamazaki, H." "J Pharm Health Care Sci" 6 20 2020 原著論文 "Expression of functional sulfotransferases (SULT) 1A1, 1A3, 1B1, 1C2, 1E1, and 2A1 in common marmosets" "Uno, Y.; Uehara, S.; Murayama, N.; Shimizu, M.; Yamazaki, H." "Biochem Pharmacol" 180 114189 2020 原著論文 "Correction to Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers""""" "Uehara, S.; Uno, Y.; Inoue, T.; Kawano, M.; Shimizu, M.; Toda, A.; M., U.; Sasaki, E.; Yamazaki, H." "Drug Metab Dispos" 48 723 2020 原著論文 "Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations" "Ogawa, S. I.; Shimizu, M.; Yamazaki, H." Xenobiotica 50 1413-1422 2020 原著論文 "Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats" "Kamiya, Y.; Otsuka, S.; Miura, T.; Yoshizawa, M.; Nakano, A.; Iwasaki, M.; Kobayashi, Y.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H." "Chem Res Toxicol" 33 1736-1751 2020 原著論文 "Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation" "Dionisio, L.; Shimizu, M.; Stupniki, S.; Oyama, S.; Aztiria, E.; Alda, M.; Yamazaki, H.; Spitzmaul, G." "Drug Metab Pharmacokinet" 35 383-388 2020 原著論文 "Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1" "Ogawa, S. I.; Shimizu, M.; Kamiya, Y.; Uehara, S.; Suemizu, H.; Yamazaki, H." "Drug Metab Pharmacokinet" 35 354-360 2020 原著論文 "Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity" "Kamiya, Y.; Takaku, H.; Yamada, R.; Akase, C.; Abe, Y.; Sekiguchi, Y.; Murayama, N.; Shimizu, M.; Kitajima, M.; Shono, F.; Funatsu, K.; Yamazaki, H." "Toxicol Rep" 7 149-154 2020 原著論文 "Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment" "Ogawa, S. I.; Shimizu, M.; Yamazaki, H." Xenobiotica 50 1023-1031 2020 原著論文 "Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice" "Miura, T.; Uehara, S.; Shimizu, M.; Murayama, N.; Utoh, M.; Suemizu, H.; Yamazaki, H." "Chem Res Toxicol" 33 634-639 2020 原著論文 "Simple pharmacokinetic models accounting for drug monitoring results of atomoxetine and its 4-hydroxylated metabolites in Japanese pediatric patients genotyped for cytochrome P450 2D6" "Notsu, Y.; Shimizu, M.; Sasaki, T.; Nakano, A.; Ota, M.; Yoshida, S.; Yamazaki, H." "Drug Metab Pharmacokinet" 35 191-200 2020 原著論文 "Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling" "Ota, M.; Shimizu, M.; Kamiya, Y.; Emoto, C.; Fukuda, T.; Yamazaki, H." "Biopharm Drug Dispos" 40 350-357 2019 原著論文 "Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database" "Shimizu, M.; Yoda, H.; Nakakuki, K.; Saso, A.; Saito, I.; Hishinuma, E.; Saito, S.; Hiratsuka, M.; Yamazaki, H." "Drug Metab Pharmacokinet" 34 334-339 2019 原著論文 "Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data" "Miura, T.; Uehara, S.; Nakazato, M.; Kusama, T.; Toda, A.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Suemizu, H.; Yamazaki, H." "J Toxicol Sci" 44 543-548 2019 原著論文 "Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate" "Miura, T.; Uehara, S.; Mizuno, S.; Yoshizawa, M.; Murayama, N.; Kamiya, Y.; Shimizu, M.; Suemizu, H.; Yamazaki, H." "Chem Res Toxicol" 32 333-340 2019 原著論文 "Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria" "Shimizu, M.; Yoda, H.; Igarashi, N.; Makino, M.; Tokuyama, E.; Yamazaki, H." Xenobiotica 49 1244-1250 2019 原著論文 "Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital" "Yamazaki-Nishioka, M.; Kogiku, M.; Noda, M.; Endo, S.; Takekawa, M.; Kishi, H.; Ota, M.; Notsu, Y.; Shimizu, M.; Yamazaki, H." Xenobiotica 49 1001-1006 2019 原著論文 "Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate" "Miura, T.; Suemizu, H.; Goto, M.; Sakai, N.; Iwata, H.; Shimizu, M.; Yamazaki, H." Xenobiotica 49 513-520 2019 原著論文 "Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques" "Uno, Y.; Shimizu, M.; Yoda, H.; Origuchi, Y.; Yamazaki, H." "Drug Metab Pharmacokinet" 34 104-107 2019 原著論文 "Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney" "Uno, Y.; Shimizu, M.; Yoda, H.; Yamazaki, H." "J Med Primatol" 48 51-53 2019 原著論文 "In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants" "Nakanishi, K.; Uehara, S.; Kusama, T.; Inoue, T.; Shimura, K.; Kamiya, Y.; Murayama, N.; Shimizu, M.; Uno, Y.; Sasaki, E.; Yamazaki, H." "Biochem Pharmacol" 152 272-278 2018 原著論文 "Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice" "Shimizu, M.; Suemizu, H.; Mizuno, S.; Kusama, T.; Miura, T.; Uehara, S.; Yamazaki, H." "J Toxicol Sci" 43 387-393 2018 原著論文 "Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine" "Wang, L.; Bernert, J. T.; Benowitz, N. L.; Feng, J.; Jacob, P., 3rd; McGahee, E.; Caudill, S. P.; Scherer, G.; Scherer, M.; Pluym, N.; Doig, M. V.; Newland, K.; Murphy, S. E.; Caron, N. J.; Sander, L. C.; Shimizu, M.; Yamazaki, H.; Kim, S.; Langman, L. J.; Pritchett, J. S.; Sniegoski, L. T.; Li, Y.; Blount, B. C.; Pirkle, J. L." "Cancer Epidemiol Biomarkers Prev" 27 1083-1090 2018 原著論文 "Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA" "Murayama, N.; Suemizu, H.; Uehara, S.; Kusama, T.; Mitsui, M.; Kamiya, Y.; Shimizu, M.; Guengerich, F. P.; Yamazaki, H." "J Toxicol Sci" 43 369-375 2018 原著論文 "Dihydrocodeine Overdoses in a Neonate and in a 14-year-old Girl Who Were Both Genotyped as Cytochrome P450 2D6*1/*10-*36: Comparing Developmental Ages and Drug Monitoring Data With the Results of Pharmacokinetic Modeling" "Shimizu, M.; Kondo, T.; Fukuoka, T.; Tanaka, T.; Yamazaki, H." "Ther Drug Monit" 40 162-165 2018 原著論文 "Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models" "Kusama, T.; Toda, A.; Shimizu, M.; Uehara, S.; Inoue, T.; Uno, Y.; Utoh, M.; Sasaki, E.; Yamazaki, H." Xenobiotica 48 1072-1077 2018 原著論文 "Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19" "Toda, A.; Uehara, S.; Inoue, T.; Utoh, M.; Kusama, T.; Shimizu, M.; Uno, Y.; Mogi, M.; Sasaki, E.; Yamazaki, H." Xenobiotica 48 720-726 2018 原著論文 "R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys" "Utoh, M.; Kusama, T.; Miura, T.; Mitsui, M.; Kawano, M.; Hirano, T.; Shimizu, M.; Uno, Y.; Yamazaki, H." Xenobiotica 48 206-210 2018 原著論文 "Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice" "Yamazaki-Nishioka, M.; Shimizu, M.; Suemizu, H.; Nishiwaki, M.; Mitsui, M.; Yamazaki, H." Xenobiotica 48 117-123 2018 原著論文 "Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models" "Utoh, M.; Miura, T.; Kusama, T.; Uehara, S.; Shimizu, M.; Uno, Y.; Yamazaki, H." "Biopharm Drug Dispos" 38 439-442 2017 原著論文 "Effects of Meat Intake Frequency and Polymorphic Cytochrome P450 2A6 Activity on Individual Colorectal Tumour Risk in a Japanese Cohort" "Yamazaki, H.; Fujieda, M.; Shimizu, M.; Shiotani, A.; Shimabukuro, M.; Mure, K.; Takeshita, T.; Ishikawa, H." "Journal of Cancer Therapy" 8 645-652 2017 原著論文 "Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model" "Shimizu, M.; Yamazaki, H." "J Toxicol Sci" 42 485-490 2017 原著論文 "Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects" "Tahara, A.; Tahara, N.; Yamagishi, S. I.; Honda, A.; Igata, S.; Nitta, Y.; Bekki, M.; Nakamura, T.; Sugiyama, Y.; Sun, J.; Takeuchi, M.; Shimizu, M.; Yamazaki, H.; Fukami, K.; Fukumoto, Y." "Int J Food Sci Nutr" 68 1013-1020 2017 原著論文 "Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase" "Uehara, S.; Shimizu, M.; Uno, Y.; Inoue, T.; Sasaki, E.; Yamazaki, H." "Drug Metab Dispos" 45 497-500 2017 原著論文 "Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice" "Shimizu, M.; Suemizu, H.; Mitsui, M.; Shibata, N.; Guengerich, F. P.; Yamazaki, H." Xenobiotica 47 844-848 2017 原著論文 "Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers" "Murayama, N.; Shimizu, M.; Kobayashi, K.; Kishimoto, I.; Yamazaki, H." "Drug Metab Lett" 10 240-243 2017 原著論文 "Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules" "Mori, K.; Saito, R.; Nakamaru, Y.; Shimizu, M.; Yamazaki, H." "Biopharm Drug Dispos" 37 491-506 2016 原著論文 " Assessment of protein binding of 5-hydroxythalidomide bioactivated in humanized mice with human P450 3A-chromosome or hepatocytes by two-dimensional electrophoresis/accelerator mass spectrometry. " "Yamazaki, H., Suemizu, H., Kazuki, Y., Oofusa, K., Kuribayashi, S., Shimizu, M., Ninomiya, S., Horie, T., Shibata, N., and Guengerich, F. P." "Chem. Res. Toxicol." 29 1279-1281 2016 原著論文 "Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling. " "Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H." Xenobiotica 46 1049-1055 2016 原著論文 "Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Biopharm. Drug Dispos." 37 310-313 2016 原著論文 "Individual differences in metabolic clearance of S-warfarin efficiently mediated by polymorphic marmoset cytochrome P450 2C19 in livers." "Uehara, S., Uno, Y., Inoue, T., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H." "Drug Metab. Dispos." 44 911-915 2016 原著論文 "Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing." "Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. " "Biopharm. Drug Dispos." 37 220-232 2016 原著論文 "Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. " " Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. " Gastroenterology 150 1171-1182 2016 原著論文 "Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). " "Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. " Xenobiotica 46 163-168 2016 総説 "19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告" 山崎浩史、清水万紀子 薬剤学 75 380 2015 原著論文 "Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. " "Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H." Mol.Genet.Metab.Report 5 89-93 2015 原著論文 "Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms." "Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H." "Data in Brief" 5 " 642-645" 2015 原著論文 "Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances." "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H." "Biopharm. Drug Dispos." 36 636-643 2015 原著論文 "Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole." "Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 43 1408-1416 2015 原著論文 "Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. " "Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. " Radioisotopes 64 509-519 2015 原著論文 "Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 1119-1122 2015 原著論文 "Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling." "Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H." Regul.Toxicol.Pharmacol. 72 " 71-76" 2015 原著論文 "Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. " "Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 95 110-114 2015 原著論文 "Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling." "Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H." Xenobiotica 45 881-886 2015 原著論文 "Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). " "Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos. " 43 735-742 2015 原著論文 "Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling." "Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H." "Environ. Toxicol. Pharmacol." 39 1067-1073 2015 原著論文 "Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan." "Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. " Xenobiotica 45 757-765 2015 原著論文 "Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. " "Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H." "Biopharm. Drug Dispos." 36 148-162 2015 原著論文 "Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. " "Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S." J.Cardiovasc.Pharmacol. 65 " 289-295" 2015 原著論文 "Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans." "Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. " "Drug Metab.Pharmacokinet." 30 64-69 2015 原著論文 "Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers." "Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 " 70-74" 2015 原著論文 "Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes." "Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H." "Clinica Chimica Acta." 441 71-74 2015 原著論文 "Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase." "Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 27-33 2015 原著論文 "Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. " "Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H." Regul.Toxicol.Pharmacol. 70 468-473 2014 原著論文 "Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. " "Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H." "Regul.Toxicol.Pharmacol. " 70 214-221 2014 原著論文 "Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing." "Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H." "PLoS One" 9 e100936 2014 原著論文 "Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs." "Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 90 159-165 2014 原著論文 "Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. " "Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H." "Clin.Kidney J." 7 329 2014 原著論文 "A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)" "Ohyama, K., Shimizu, M., and Yamazaki, H." "Jpn. J. Pharm. Health Care Sci." 40 310-316 2014 原著論文 "Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population." "Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R." "Brit.J. Clin. Pharmacol." 77 839-851 2014 原著論文 "Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor." "Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H." "Chem. Res.Toxicol." 27 304-308 2014 原著論文 "Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. " "Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H." Xenobiotica 44 10-16 2014 原著論文 "Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline. " "Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K and Yamazaki H." Xenobiotica 43 1037-1042 2013 原著論文 "Effects of ADH1C, ALDH2, and CYP2A6 polymorphisms on individual risk of tobacco-related lung cancer in male Japanese smokers. " "Shimizu, M., Ishii, Y., Okubo, M., Kunitoh, H., Kamataki, T., and Yamazaki, H." "J.Cancer Ther" 4 " 28-35" 2013 原著論文 " Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque." "Uno, Y., Shimizu, M., and Yamazaki, H. " " Biochem. Pharmacol" 85 1837-1847 2013 原著論文 "The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver. " "Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F. P., and Yamazaki, H" "J. Toxicol. Sci." 38 349-34 2013 原著論文 " Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling." "Tsukada, A., Suemizu, H., Murayama, N., Takano, R., Shimizu, M., Nakamura, M., and Yamazaki, H. " Regul.Toxicol.Pharmacol. 65 " 316-324" 2013 総説 "Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities." "Yamazaki, H. and Shimizu, M. " "Biochem. Pharmacol." 85 1588-1593 2013