種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing." "Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. " "Biopharm. Drug Dispos." 37 220-232 2016 原著論文 "Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. " " Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. " Gastroenterology 150 1171-1182 2016 原著論文 "Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). " "Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. " Xenobiotica 46 163-168 2016 総説 "19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告" 山崎浩史、清水万紀子 薬剤学 75 380 2015 原著論文 "Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. " "Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H." Mol.Genet.Metab.Report 5 89-93 2015 原著論文 "Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms." "Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H." "Data in Brief" 5 " 642-645" 2015 原著論文 "Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances." "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H." "Biopharm. Drug Dispos." 36 636-643 2015 原著論文 "Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole." "Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos." 43 1408-1416 2015 原著論文 "Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. " "Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. " Radioisotopes 64 509-519 2015 原著論文 "Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 1119-1122 2015 原著論文 "Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling." "Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H." Regul.Toxicol.Pharmacol. 72 " 71-76" 2015 原著論文 "Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. " "Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 95 110-114 2015 原著論文 "Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling." "Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H." Xenobiotica 45 881-886 2015 原著論文 "Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). " "Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos. " 43 735-742 2015 原著論文 "Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling." "Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H." "Environ. Toxicol. Pharmacol." 39 1067-1073 2015 原著論文 "Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan." "Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. " Xenobiotica 45 757-765 2015 原著論文 "Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. " "Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H." "Biopharm. Drug Dispos." 36 148-162 2015 原著論文 "Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. " "Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S." J.Cardiovasc.Pharmacol. 65 " 289-295" 2015 原著論文 "Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans." "Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. " "Drug Metab.Pharmacokinet." 30 64-69 2015 原著論文 "Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers." "Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 " 70-74" 2015 原著論文 "Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes." "Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H." "Clinica Chimica Acta." 441 71-74 2015 原著論文 "Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase." "Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 27-33 2015 原著論文 "Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. " "Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H." Regul.Toxicol.Pharmacol. 70 468-473 2014 原著論文 "Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. " "Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H." "Regul.Toxicol.Pharmacol. " 70 214-221 2014 原著論文 "Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing." "Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H." "PLoS One" 9 e100936 2014 原著論文 "Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs." "Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H." "Biochem. Pharmacol." 90 159-165 2014 原著論文 "Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. " "Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H." "Clin.Kidney J." 7 329 2014 原著論文 "A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)" "Ohyama, K., Shimizu, M., and Yamazaki, H." "Jpn. J. Pharm. Health Care Sci." 40 310-316 2014 原著論文 "Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population." "Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R." "Brit.J. Clin. Pharmacol." 77 839-851 2014 原著論文 "Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor." "Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H." "Chem. Res.Toxicol." 27 304-308 2014 原著論文 "Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. " "Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H." Xenobiotica 44 10-16 2014 原著論文 "Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline. " "Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K and Yamazaki H." Xenobiotica 43 1037-1042 2013 原著論文 "Effects of ADH1C, ALDH2, and CYP2A6 polymorphisms on individual risk of tobacco-related lung cancer in male Japanese smokers. " "Shimizu, M., Ishii, Y., Okubo, M., Kunitoh, H., Kamataki, T., and Yamazaki, H." "J.Cancer Ther" 4 " 28-35" 2013 原著論文 " Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque." "Uno, Y., Shimizu, M., and Yamazaki, H. " " Biochem. Pharmacol" 85 1837-1847 2013 原著論文 "The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver. " "Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F. P., and Yamazaki, H" "J. Toxicol. Sci." 38 349-34 2013 原著論文 " Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling." "Tsukada, A., Suemizu, H., Murayama, N., Takano, R., Shimizu, M., Nakamura, M., and Yamazaki, H. " Regul.Toxicol.Pharmacol. 65 " 316-324" 2013 総説 "Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities." "Yamazaki, H. and Shimizu, M. " "Biochem. Pharmacol." 85 1588-1593 2013