種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells" "Sugiyama, I., Murayama, N., Kuroki, A., Kota, J., Iwano, S., Yamazaki, H., and Hirota, T" Xenobiotica 46 " 765-774" 2016 原著論文 "Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing." "Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. " "Biopharm. Drug Dispos." 37 220-232 2016 原著論文 "Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5. Hum." "Okubo, M., Morita, S., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. " Psychopharmacol.Clin.Exp. 31 93-102 2016 原著論文 "Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P450 2D6 and flavin-containing monooxygenase 3. Hum." "Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. " Psychopharmacol.Clin.Exp. 31 83-92 2016 原著論文 "In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans. " "Sekiguchi, K., Kanazu, T., Murayama, N., Yamazaki, H., and Yamaguchi, T." Xenobiotica 46 495-502 2016 原著論文 "Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene by human cytochrome P450 2A13. " "317. Shimada, T., Takenaka, S., Murayama, N., Kramlinger, V. M., Kim, J.-H., Kim, D., Foroozesh, M. K., Yamazaki, H., Guengerich, F. P., and Komori, M." Xenobiotica 46 " 211-224" 2016 総説 "Regioselective hydroxylation of steroid hormones by human cytochromes P450." " Niwa, T., Murayama, N., Imagawa, Y., and Yamazaki, H." "Drug Metab. Rev." 47 89-110 2015 原著論文 "Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances." "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H." "Biopharm. Drug Dispos." 36 636-643 2015 原著論文 "Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. " "Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. " Radioisotopes 64 509-519 2015 原著論文 "Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. " "Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 1119-1122 2015 原著論文 "Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling." "Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H." Regul.Toxicol.Pharmacol. 72 " 71-76" 2015 原著論文 "Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling." "Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H." Xenobiotica 45 881-886 2015 原著論文 "Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). " "Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. " "Drug Metab. Dispos. " 43 735-742 2015 原著論文 "Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling." "Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H." "Environ. Toxicol. Pharmacol." 39 1067-1073 2015 原著論文 "Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan." "Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. " Xenobiotica 45 757-765 2015 原著論文 "CYP2D44 polymorphisms in cynomolgus and rhesus macaques." "Uno, Y., Uehara, S., Kohara, S., Osada, N., Murayama, N., and Yamazaki,H." Mol.Biol.Rep. 42 1149–1155 2015 原著論文 "Oxidation of acenaphthene and acenaphthylene by human cytochrome P450 enzymes." "Shimada, T., Takenaka, S., Murayama, N., Yamazaki, H., Kim, J. H., Kim, D., Yoshimoto, F. K., Guengerich, F. P., and Komori, M." "Chem. Res.Toxicol." 28 " 268-278" 2015 原著論文 "Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays." "Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H." "Drug Metab.Lett." 9 3-7 2015 原著論文 "A. Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models. " "Watanabe, Y., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Murayama, N., Sugiyama, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama" "Basic Clin.Pharmacol.Toxicol." 116 468-475 2015 原著論文 "Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole, and metoprolol, in cynomolgus monkeys using in vitro-in vivo correlation." "Koyanagi, T., Nakanishi, Y., Murayama, N., Yamaura, Y., Ikeda, K., Yano, K., Uehara, S., Utoh, M., Kim, S., Uno, Y., and Yamazaki, H." Xenobiotica 45 312-321 2015 原著論文 "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9. " "Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H." "Drug Metab.Pharmacokinet." 30 130-132 2015 原著論文 "Immunochemical quantification of cynomolgus CYP2J2, CYP4A, and CYP4F enzymes in liver and small intestine." "Uehara, S., Murayama, N., Nakanshi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y." " Xenobiotica" 45 124-130 2015 原著論文 "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." "Okubo, M., Murayama, N., Miura, J., Chiba, Y., and Yamazaki, H." "Biochem. Pharmacol." 93 104-109 2015 原著論文 "Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase." "Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. " "Drug Metab. Dispos." 43 27-33 2015 原著論文 "Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation." "Niwa T, Yasumura M, Murayama N and Yamazaki H." "Drug Metab.Lett." 8 43-50 2014 原著論文 "CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. " "Uno, Y., Matsushita, A., Shukuya, M., Matsumoto, Y., Murayama, N., and Yamazaki, H. " "Biochem. Pharmacol." 91 " 242-248" 2014 原著論文 "Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism." "Uno, Y., Uehara, S., Kohara, S., Murayama, N., and Yamazaki, H." "Drug Metab. Dispos." 42 1407-1410 2014 原著論文 "Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. " "Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H." "Regul.Toxicol.Pharmacol. " 70 214-221 2014 原著論文 "Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing." "Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H." "PLoS One" 9 e100936 2014 原著論文 "K. Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 Inhibitor teneligliptin: an open-label study in healthy white subjects in Germany." "Nakamaru, Y., Hayashi, Y., Sekine, M., Kinoshita, S., Thompson, J., Kawaguchi, A., Davies, M., Jurgen, Heuer H., Yamazaki, H., and Akimoto" Clin.Ther. 36 760-769 2014 原著論文 "Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig. Biopharm." "Higashi, E., Ando, A., Iwano, S., Murayama, N., Yamazaki, H., and Miyamoto, S. " "Drug Dispos." 35 313-320 2014 原著論文 "Yajima, K., Uno, Y., Murayama, N., Uehara, S., Shimizu, M., Nakamura, C., Iwasaki, K., Utoh, M., and Yamazaki, H." "Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. " "Drug Metab. Dispos" 42 867-871 2014 原著論文 "Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys." "Uehara, S., Murayama, N., Nakanishi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y." Xenobiotica 44 769-774 2014 原著論文 "Voriconazole metabolism, toxicity and the effect of cytochrome P450 2C19 genotype. " "Zonios, D., Yamazaki, H., Murayama, N., Natrarajan, V., Palmore, T., Childs, R., Skinner, J., and Bennett, J." J.Infect.Dis. 209 1941-1948 2014 原著論文 "Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor." "Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H." "Chem. Res.Toxicol." 27 304-308 2014 原著論文 "Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. " "Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H." Xenobiotica 44 10-16 2014