種別 タイトル 著者 誌名 巻号 ページ 出版年 DOI URL 原著論文 "High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice." "Ishii I, Kamata S, Ito S, Shimonaga A, Koizumi M, Tsushima M, Miura A, Nagata T, Tosaka Y, Ohtani H, Kamichatani W, Akahoshi N." "Int J Mol Sci." 23 928 2022 10.3390/ijms23020928. 総説 硫化水素産生・代謝酵素の役割：ヒト遺伝病と病態モデルマウスからの知見 "赤星 軌征，石井 功" 生化学 93 754-759 2021 10.14952/SEIKAGAKU.2021.930754 原著論文 "Homocysteine Hypothesis on the Impaired Peripheral but Not Central Nervous System Oxytocin Responses in Cystathionine γ-Lyase-Deficient Dam Mice." "Akahoshi N, Kamichatani W, Ishii I." "Biol Pharm Bull." 43 1810-1813 2020 10.1248/bpb.b20-00676. 原著論文 "Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines." "Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I." "Toxicol In Vitro." 69 104999 2020 10.1016/j.tiv.2020.104999. 原著論文 "Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4." "Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S." "J Clin Invest." 130 121955 2019 10.1172/JCI121955 原著論文 "Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria." "Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I." "Int J Mol Sci." 20 E3507 2019 10.3390/ijms20143507 原著論文 "Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria." "Akahoshi N, Yokoyama A, Nagata T, Miura A, Kamata S, Ishii I." "Biol Pharm Bull." 42 1054-1057 2019 10.1248/bpb.b19-00127 原著論文 "Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice." "Akahoshi N, Anan Y, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada KI, Kamata S, Ishii I." "J Nutr Biochem." 69 120-129 2019 10.1016/j.jnutbio.2019.03.020 原著論文 "The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity." "Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T." "JCI Insight" 3 97293 2018 10.1172/jci.insight.97293 原著論文 "Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice." "Borowczyk K, Wróblewski J, Suliburska J, Akahoshi N, Ishii I, Jakubowski H." "Int J Genomics" 2018 7570850 2018 "doi: 10.1155/2018/7570850." 原著論文 "2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice." "Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I." "FEBS Open Bio." 8 1524-1543 2018 10.1002/2211-5463.12497 原著論文 "Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure." "Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M." Hypertension 71 1210-1217 2018 "doi: 10.1161/HYPERTENSIONAHA.117.10562." 原著論文 "LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model." "Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, Ishii S, Akahoshi N, Yanagida K, Sumida H, Araki M, Araki K, Yamamura KI, Murakami-Murofushi K, Ueda H." "J Pharmacol Sci." 136 93-96 2018 10.1016/j.jphs.2018.01.001 原著論文 "Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility." "Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E." "eLife " 5 e10561 2016 原著論文 "Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes." "Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M" "Int Immuno" 28 283-292 2016 原著論文 "2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice." "Kamata S, Akahoshi N, Ishii I" "FEBS Open Bio" 5 535-541 2015 原著論文 "Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions." "Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M" "J Mol Med" 93 879-889 2015 原著論文 "The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells." "Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S" "Sci Rep " 5 11410 2015 原著論文 "Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice." "Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I" "Toxicol Appl Pharmacol " 282 195-206 2015 原著論文 "Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria." "Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I" "Am J Physiol Renal Physiol " 306 F1462-F1476 2014 原著論文 "TDAG8 activation inhibits osteoclastic bone resorption." "Hikiji H, Endo D, Horie K, Harayama T, Akahoshi N, Igarashi H, Kihara Y, Yanagida K, Takeda J, Koji T, Shimizu T, Ishii S" "FASEB J" 28 871-879 2014 原著論文 "Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria." "Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I" "Free Radic Biol Med" 52 1716-1726 2012 原著論文 "TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates." "Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I" "Anal Bioanal Chem" 402 1859-1864 2011 原著論文 "Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria." "Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I" "Anal Bioanal Chem" 400 1853-1863 2011 原著論文 "Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2." "Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I" "Epilepsy Behav" 22 659-665 2011 原著論文 "Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury." "Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M" "J Biol Chem" 285 26358-26368 2010 原著論文 "Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia." "Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I" "Hum Mol Genet" 17 1994-2005 2008 原著論文 "Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures." "Akahoshi N, Murashima YL, Himi T, Ishizaki Y, Ishii I" "Neurosci Lett" 429 136-141 2007 総説 システイン生合成経路の破綻による病態. "石井功, 赤星軌征" アミノ酸研究 1 37-39 2007 原著論文 "Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation." "Akahoshi N, Izumi T, Ishizaki Y, Ishii I" "Biol Pharm Bull" 29 1799-1802 2006 原著論文 "Murine cystathionine γ-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression." "Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, and Kimura H" "Biochem J" 381 113-123 2004 原著論文 "Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria." "Akahoshi N, Minakawa T, Miyashita M, Sugiyama U, Saito C, Takemoto R, Honda A, Kamichatani W, Kamata S, Anan Y, Ishii I." "Int J Mol Sci. " 21 818 .2020 10.3390/ijms21030818.