Profile

Name

Noriyuki Akahoshi

Affiliation

Laboratory of Health Chemistry

Subjects

　

Official title

Associate Professor

Degree

　

Papers

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• [Original paper]　A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.　Ishii I, Kamata S, Ito S, Shimonaga A, Koizumi M, Tsushima M, Miura A, Nagata T, Tosaka Y, Ohtani H, Kamichatani W, Akahoshi N.　Int J Mol Sci.　23　928　2022　
• [Review]　硫化水素産生・代謝酵素の役割：ヒト遺伝病と病態モデルマウスからの知見　Akahoshi N, Ishii I.　Journal of Japanese Biochemical Society 　93　754-759　2021　
• [Original paper]　Homocysteine Hypothesis on the Impaired Peripheral but Not Central Nervous System Oxytocin Responses in Cystathionine γ-Lyase-Deficient Dam Mice.　Akahoshi N, Kamichatani W, Ishii I.　Biol Pharm Bull.　43　1810-1813　2020　
• [Original paper]　Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines.　Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.　Toxicol In Vitro.　69　104999　2020　
• [Original paper]　Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria. 　Akahoshi N, Minakawa T, Miyashita M, Sugiyama U, Saito C, Takemoto R, Honda A, Kamichatani W, Kamata S, Anan Y, Ishii I.　Int J Mol Sci.　21　818　2020　
• [Original paper]　Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.　Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S.　J Clin Invest.　130　4332-4349　2019　
• [Original paper]　Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria.　Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I　Int J Mol Sci.　20　E3507　2019　
• [Original paper]　Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria. 　Akahoshi N, Yokoyama A, Nagata T, Miura A, Kamata S, Ishii I　Biol Pharm Bull.　42　1054-1057　2019　
• [Original paper]　Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice.　Akahoshi N*, Anan Y*, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada KI, Kamata S, Ishii I　J Nutr Biochem.　69　120-129　2019　
• [Original paper]　The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity.　Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T.　JCI Insight.　3　97293　2018　
• [Original paper]　Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice.　Borowczyk K, Wróblewski J, Suliburska J, Akahoshi N, Ishii I, Jakubowski H.　Int J Genomics.　2018　7570850　2018　
• [Original paper]　2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice.　Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I.　FEBS Open Bio.　8　1524-1543　2018　
• [Original paper]　Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.　Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M.　Hypertension　71　1210-1217　2018　
• [Original paper]　LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.　Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, Ishii S, Akahoshi N, Yanagida K, Sumida H, Araki M, Araki K, Yamamura KI, Murakami-Murofushi K, Ueda H.　J Pharmacol Sci.　136　93-96　2018　
• [Original paper]　Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.　Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.　eLife 　5　e10561　2016　
• [Original paper]　Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.　Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M　Int Immuno　28　283-292　2016　
• [Original paper]　2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice.　Kamata S, Akahoshi N, Ishii I　FEBS Open Bio　5　535-541　2015　
• [Original paper]　Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.　Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M　J Mol Med　93　879-889　2015　
• [Original paper]　The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.　Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S　Sci Rep 　5　11410　2015　
• [Original paper]　Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.　Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I　Toxicol Appl Pharmacol 　282　195-206　2015　
• [Original paper]　Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.　Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I　Am J Physiol Renal Physiol 　306　F1462-F1476　2014　
• [Original paper]　TDAG8 activation inhibits osteoclastic bone resorption.　Hikiji H, Endo D, Horie K, Harayama T, Akahoshi N, Igarashi H, Kihara Y, Yanagida K, Takeda J, Koji T, Shimizu T, Ishii S　FASEB J　28　871-879　2014　
• [Original paper]　Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.　Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I　Free Radic Biol Med　52　1716-1726　2012　
• [Original paper]　TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates.　Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I　Anal Bioanal Chem　402　1859-1864　2011　
• [Original paper]　Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria.　Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I　Anal Bioanal Chem　400　1853-1863　2011　
• [Original paper]　Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2.　Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I　Epilepsy Behav　22　659-665　2011　
• [Original paper]　Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.　Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M　J Biol Chem　285　26358-26368　2010　
• [Original paper]　Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia.　Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I　Hum Mol Genet　17　1994-2005　2008　
• [Original paper]　Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.　Akahoshi N, Murashima YL, Himi T, Ishizaki Y, Ishii I　Neurosci Lett　429　136-141　2007　
• [Review]　システイン生合成経路の破綻による病態.　石井功, 赤星軌征　アミノ酸研究　1　37-39　2007　
• [Original paper]　Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation.　Akahoshi N, Izumi T, Ishizaki Y, Ishii I　Biol Pharm Bull　29　1799-1802　2006　
• [Original paper]　Murine cystathionine γ-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression.　Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, and Kimura H　Biochem J　381　113-123　2004　

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Conference, etc.

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• [Poster presentation]　硫化水素産生酵素CthおよびMpst欠損マウスにおけるハプテン誘導性接触性皮膚炎.　赤星 軌征, 長谷川 凌花, 上茶谷 若, 石井 功　日本薬学会第142年会　名古屋（オンライン）　2022/3
• [Poster presentation]　Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine gamma-Lyase.　Akahoshi N, Handa T, Takemot R, Kamata S, Kamichatani W, Ishii I　The 45th FEBS Virtual Congress　Ljubljana, Slovenija (on line)　2021/7
• [Poster presentation]　活性硫黄分子産生酵素Mpst及びCthの単独欠損マウス、そしてMpst/Cthダブル欠損マウスの比較解析.　赤星 軌征, 皆川 達郎, 齊藤 千紘, 杉山 宇蘭, 宮下 雅嗣, 竹本 麟太郎, 本田 彰宏, 梶原 若, 鎌田 祥太朗, 阿南 弥寿美, 石井 功　日本薬学会第140年会　京都（誌上開催）　2020/3
• [Poster presentation]　Cth欠損母親マウスで発生する末梢性かつ非中枢性のオキシトシン応答障害におけるホモシステイン仮説.　赤星 軌征, 上茶谷 若, 石井 功　第43回日本分子生物学会年会　オンライン　2020/12
• [Oral presentation]　Cystathionine γ-lyase 欠損母親マウスにおけるオキシトシン応答不全　赤星 軌征, 半田 博紀, 石井 功　日本薬学会関東支部大会　東京　2019/9
• [Oral presentation]　射乳不全による Cystathionine γ-lyase 欠損母親マウスにおける育児不良.　赤星 軌征, 半田 博紀, 石井 功.　フォーラム2019 衛生薬学・環境トキシコロジー　京都　2019/8
• [Poster presentation]　Cystathionine γ-lyase 欠損母マウスにおける授乳異常. 　赤星 軌征, 半田 博紀, 横山 輝, 石井 功　日本生化学会関東支部例会　東京　2019/6
• [Poster presentation]　Cystathionine gamma-lyase 欠損母マウスにおける授乳行動異常.　赤星 軌征, 半田 博紀, 横山 輝, 石井 功　日本薬学会年会　金沢　2018/3
• [Poster presentation]　赤星 軌征, 半田 博紀, 石井 功.　Cystathionine gamma-lyase 欠損マウスにおける妊娠高血圧症候群と育児放棄. 　フォーラム2017 衛生薬学・環境トキシコロジー　仙台　2017/9
• [Oral presentation]　Exacerbation of passive anaphylaxis in LPA5 deficient mice.　Akahoshi N, Taketomi Y, Murakami M, Ishii S　日本生化学会大会　仙台　2016/09/25
• [Oral presentation]　リゾホスファチジン酸第5受容体 (LPA5) シグナルによるマスト細胞抑制機構　赤星軌征, 武富芳隆, 村上誠, 石井聡　日本脂質生化学会　秋田　2016/06/09
• [Poster presentation]　Neutral aminoaciduria in cystathionine beta-synthase-deficient mice, an animal model of homocystinuria.　Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I　日本生化学会大会　京都　2014/10/15
• [Poster presentation]　TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates.　Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I　日本生化学会大会　福岡　2012/12/14
• [Oral presentation]　GPCRと炎症性腸疾患　赤星軌征, 石井聡　新学術領域「脂質マシナリー」若手ワークショップ　東京　2012/02/01
• [Poster presentation]　Frequent spontaneous seizures followed by enhanced hippocampal gliosis and spatial working memory/anxiety deficits in mice lacking the sphingosine 1-phosphate receptor 2.　Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I　日本生化学会大会　京都　2011/09/21
• [Poster presentation]　Pregnancy-induced hypertension and proteinuria in hyperhomocysteinemic mice.　Akahoshi N, Suematsu M, Ishii I　日本生化学会大会　神戸　2010/12/07
• [Poster presentation]　Metabolomic analysis of kidneys in CBS-deficient mice using CE-MS.　Akahoshi N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Ishii I　日本生化学会大会　神戸　2009/10/21
• [Poster presentation]　Disorders in homocysteine metabolism: Impaired tubular amino acid reabsorption in genetically engineered mouse models for homocystiuria and cystathioninuria. 　Akahoshi N, Ishii I　日本分子生物学会・日本生化学会合同年会　神戸　2008/12/09
• [Poster presentation]　The CNS abnormality in adult cystathionine β-synthase-deficient mice.　Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I　日本神経科学会　東京　2008/09/11
• [Poster presentation]　Genechip analysis of the neocortical and hippocampal gene expression in kainate- and nicotine-injected mice. 　Akahoshi N, Murashima YL, Himi T, Ishizaki Y, Ishii I　日本神経科学会　横浜　2007/09/10
• [Poster presentation]　Cystathionine γ-lyase-deficient mice as animal models for cystathioninemia. 　Akahoshi N, Izumi T, Ishizaki Y, Ishii I　日本分子生物学会・日本生化学会合同年会　京都　2006/06/18
• [Oral presentation]　マウスてんかん誘導モデルにおける脳内遺伝子発現の変化　赤星軌征, 石井功　日本薬学会年会　東京　2005/03/29
• [Oral presentation]　Characterization of cystathionine γ-lyase in mice, a key enzyme in the transsulfuration pathway for the biosynthesis of cysteine. 　赤星軌征, 喩小念, 小林友里子, 行方和彦, 木村英雄, 石井功　日本生化学会大会　横浜　2004/10/13
• [Poster presentation]　Oogenesis in hydra, analysis by DD-RT-PCR.　Akahoshi N, Tada A, Koizumi O, Kobayakawa Y　International workshop on hydroid development　Tutzing (Germany)　1997/09/22
• [Oral presentation]　ヒドラの卵形成に関わる遺伝子の検索.　赤星軌征, 多田在倫, 小泉修, 小早川義尚　日本発生生物学会年会　筑波　1997/05/27

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