SPU DMPK in English

Laboratory of Drug Metabolism and Pharmacokinetics

We are currently involved in research areas related to individual variability in drug response and drug safety. To achieve optimal personalized drug-therapy, our research is going on drug absorption, distribution, metabolism, and excretion for the efficacy and safety of personalized medicines.

Processes in pharmacokinetics, including drug absorption, distribution, metabolism (biotransformation) and excretion, are influenced by many factors belonging to drugs and their dosage forms, to physiological or genetic variables of the individual patients, and to effects of other drugs taken concurrently.

We focuse characteristics of drug-metabolizing enzymes (such as cytochromes P450, flavin-containing monooxygenases, and UDP-glucuronosyltransferases) and of pharmacokinetics of clinically important medicines. Both phenotype and genotype studies for patients are ongoing in this laboratory.

Hiroshi Yamazaki, PhD, Professor
Makiko Shimizu, PhD, Research Associate
Norie Murayama, PhD, Research Associate

doutai(at mark)ac.shoyaku.ac.jp

Last updated on Nov-15-2009